Taf3 TATA-box binding protein associated factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taf3provided by MGI
Official Full Name: TATA-box binding protein associated factor 3provided by MGI
Primary source: MGI:MGI:2388097
See related: Ensembl:ENSMUSG00000025782 AllianceGenome:MGI:2388097
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 140kDa; TAF140; TAFII140; TAFII-140; mTAFII140; 4933439M23Rik
Summary: Enables p53 binding activity and transcription regulator inhibitor activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including eye; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human TAF3 (TATA-box binding protein associated factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 3.3), testis adult (RPKM 3.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 6.74 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (9919363..10053420, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (9914552..10048609, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that TATA box binding protein-associated factor TAF3 as a direct target of nuclear phosphoinositides (PI).
Title: The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output.
Study shows that this TAF3 activity is critical for early lineage segregation during stem cell differentiation.
Title: Control of embryonic stem cell lineage commitment by core promoter factor, TAF3.
In vitro and cell-based assays identify a domain of TAF3 that mediates coactivator functions targeted by MyoD.
Title: MyoD targets TAF3/TRF3 to activate myogenin transcription.
Results report the solution structure of the TAF3-PHD finger and its complex with an H3K4me3 peptide.
Title: Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Taf3 (e-PCR), detects polymorphism
- UniSTS:547377

NoName (e-PCR)
- UniSTS:234325

D2Mit233 (e-PCR), detects polymorphism
- UniSTS:129110

AW539625 (e-PCR)
- UniSTS:178567

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	IBA Inferred from Biological aspect of Ancestor more info
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription regulator inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in maintenance of protein location in nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 3

Names: 140 kDa TATA box-binding protein-associated factor; RNA polymerase II transcription factor, TFIID subunit; TAF(II)140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa; TBP-associated factor 3; transcription initiation factor TFIID 140 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027748.3 → NP_082024.2 transcription initiation factor TFIID subunit 3

See identical proteins and their annotated locations for NP_082024.2

Status: VALIDATED

Source sequence(s)

AK136045, AW049595, BB621106, BC137618, CX763644

Consensus CDS

CCDS15675.1

UniProtKB/Swiss-Prot

Q3U490, Q3UWX2, Q5HZG4, Q8BIU8, Q99JH4

UniProtKB/TrEMBL

A2ASY0, A2ASY1

Related

ENSMUSP00000026888.5, ENSMUST00000026888.11

Conserved Domains (3) summary

smart00576
Location:5 → 79

BTP; Bromodomain transcription factors and PHD domain containing proteins

cd15522
Location:869 → 914

PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)

pfam16294
Location:607 → 656

RSB_motif; RNSP1-SAP18 binding (RSB) motif