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Eif2b1 eukaryotic translation initiation factor 2B, subunit alpha [ Mus musculus (house mouse) ]

Gene ID: 209354, updated on 5-Mar-2024

Summary

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Official Symbol
Eif2b1provided by MGI
Official Full Name
eukaryotic translation initiation factor 2B, subunit alphaprovided by MGI
Primary source
MGI:MGI:2384802
See related
Ensembl:ENSMUSG00000029388 AllianceGenome:MGI:2384802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EIF2BA; D5Ertd406e
Summary
This gene encodes the alpha subunit of the eukaryotic translation initiation factor complex 2B (eIF2B). The eIF2B complex is a heterodecamer comprised of two molecules each of alpha, beta, gamma, delta and epsilon subunits. The eIF2B complex is a critical regulator of protein synthesis acting as the guanine nucleotide exchange factor for eIF2 to enable the formation of ternary complex that is required for the initiation of mRNA translation. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in placenta adult (RPKM 18.0), liver E14 (RPKM 13.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 63.67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124708277..124717194, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124570214..124579131, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3619 Neighboring gene STARR-positive B cell enhancer ABC_E3620 Neighboring gene DEAD box helicase 55 Neighboring gene STARR-positive B cell enhancer ABC_E8083 Neighboring gene general transcription factor IIH, polypeptide 3 Neighboring gene STARR-positive B cell enhancer ABC_E10353 Neighboring gene tectonic family member 2 Neighboring gene STARR-seq mESC enhancer starr_14344

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new function and complexity for protein translation initiation factor eIF2B. Jennings MD, et al. Cell Cycle, 2014. PMID 25486352, Free PMC Article
  2. Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation. Wortham NC, et al. FASEB J, 2014 May. PMID 24532666
  3. Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease. Pavitt GD, et al. Biochem Soc Trans, 2009 Dec. PMID 19909266
  4. Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions. Kubica N, et al. Prog Nucleic Acid Res Mol Biol, 2006. PMID 16891174
  5. Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease. Cabilly Y, et al. PLoS One, 2012. PMID 23056417, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These are the first data that mechanistically link eIF2Bepsilon abundance to skeletal myofibre hypertrophy.
    Title: Eukaryotic initiation factor 2B epsilon induces cap-dependent translation and skeletal muscle hypertrophy.
  2. A point mutation in translation initiation factor eIF2B leads to Vanishing White Matter disease.
    Title: A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.
  3. Inhibition of pancreatic protein synthesis in this model of acute pancreatitis most likely results from inhibition of translation initiation from increased eIF2alpha phosphorylation, reduction of eIF2B activity, and inhibition of eIF4F complex formation.
    Title: Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6458

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
  
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
  
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
  
involved_in translation ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of eukaryotic translation initiation factor 2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2B complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
translation initiation factor eIF2B subunit alpha
Names
eIF-2B GDP-GTP exchange factor subunit alpha
eIF2B GDP-GTP exchange factor subunit alpha
eukaryotic translation initiation factor 2B, subunit 1 (alpha)
eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kDa)
translation initiation factor eIF-2B subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145371.4 → NP_663346.1  translation initiation factor eIF2B subunit alpha

    See identical proteins and their annotated locations for NP_663346.1

    Status: REVIEWED

    Source sequence(s)
    AK133695, DV649595
    Consensus CDS
    CCDS39282.1
    UniProtKB/Swiss-Prot
    Q99LC8
    UniProtKB/TrEMBL
    Q3UZR8
    Related
    ENSMUSP00000031334.9, ENSMUST00000031334.15
    Conserved Domains (2) summary
    COG1184
    Location:5 → 305
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:17 → 293
    IF-2B; Initiation factor 2 subunit family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124708277..124717194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530275.5 → XP_006530338.1  translation initiation factor eIF2B subunit alpha isoform X1

    Conserved Domains (1) summary
    pfam01008
    Location:17 → 185
    IF-2B; Initiation factor 2 subunit family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LC8.1 GenPept UniProtKB/Swiss-Prot:Q99LC8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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