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Gps1 G protein pathway suppressor 1 [ Mus musculus (house mouse) ]

Gene ID: 209318, updated on 5-Mar-2024

Summary

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Official Symbol
Gps1provided by MGI
Official Full Name
G protein pathway suppressor 1provided by MGI
Primary source
MGI:MGI:2384801
See related
Ensembl:ENSMUSG00000025156 AllianceGenome:MGI:2384801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csn1; Sgn1; Cops1
Summary
Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human GPS1 (G protein pathway suppressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 101.5), testis adult (RPKM 81.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 84.54 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120675086..120679928)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120784260..120789102)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31367 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120637476-120637735 Neighboring gene NADPH-dependent carbonyl reductase pseudogene Neighboring gene STARR-seq mESC enhancer starr_31368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120657732-120657915 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1 like Neighboring gene fatty acid synthase Neighboring gene STARR-positive B cell enhancer ABC_E9039 Neighboring gene coiled-coil domain containing 57 Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome. Horváth A, et al. BMC Mol Cell Biol, 2020 May 8. PMID 32384871, Free PMC Article
  2. Expression pattern of the JAB1/CSN5 gene during murine embryogenesis: colocalization with NEDD8. Carrabino S, et al. Gene Expr Patterns, 2004 Jul. PMID 15183309
  3. Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. Tomoda K, et al. J Biol Chem, 2004 Oct 8. PMID 15299027
  4. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. Li JY, et al. Cell Signal, 2007 Jun. PMID 17276034, Free PMC Article
  5. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Lykke-Andersen K, et al. Mol Cell Biol, 2003 Oct. PMID 12972599, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome.
    Title: Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome.
  2. The present study demonstrates that Asb-4 interacts with GPS1 and inhibits JNK activity.
    Title: Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7191, MGC118012

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 1
Names
JAB1-containing signalosome subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177874.2 → NP_001171345.1  COP9 signalosome complex subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_001171345.1

    Status: VALIDATED

    Source sequence(s)
    AL663090
    Consensus CDS
    CCDS49011.1
    UniProtKB/TrEMBL
    Q3MIA8
    Related
    ENSMUSP00000112007.2, ENSMUST00000116305.8
    Conserved Domains (2) summary
    pfam01399
    Location:320 → 424
    PCI; PCI domain
    pfam10602
    Location:123 → 305
    RPN7; 26S proteasome subunit RPN7

  2. NM_001346709.2 → NP_001333638.1  COP9 signalosome complex subunit 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663090
    Consensus CDS
    CCDS83950.1
    UniProtKB/TrEMBL
    B1ATU4
    Related
    ENSMUSP00000097711.4, ENSMUST00000100134.10
    Conserved Domains (2) summary
    pfam01399
    Location:320 → 424
    PCI; PCI domain
    pfam10602
    Location:123 → 305
    RPN7; 26S proteasome subunit RPN7

  3. NM_001363440.1 → NP_001350369.1  COP9 signalosome complex subunit 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL663090
    Consensus CDS
    CCDS88299.1
    UniProtKB/TrEMBL
    A0A140LJB7
    Related
    ENSMUSP00000147152.2, ENSMUST00000208737.2
    Conserved Domains (2) summary
    pfam01399
    Location:319 → 423
    PCI; PCI domain
    pfam10602
    Location:123 → 304
    RPN7; 26S proteasome subunit RPN7

  4. NM_001405272.1 → NP_001392201.1  COP9 signalosome complex subunit 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL663090

  5. NM_001405273.1 → NP_001392202.1  COP9 signalosome complex subunit 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL663090

  6. NM_001405274.1 → NP_001392203.1  COP9 signalosome complex subunit 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL663090

  7. NM_001405275.1 → NP_001392204.1  COP9 signalosome complex subunit 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL663090

  8. NM_145370.4 → NP_663345.2  COP9 signalosome complex subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_663345.2

    Status: VALIDATED

    Source sequence(s)
    AL663090
    Consensus CDS
    CCDS25758.2
    UniProtKB/TrEMBL
    G3UXW9
    Related
    ENSMUSP00000133855.2, ENSMUST00000172809.2
    Conserved Domains (2) summary
    pfam01399
    Location:359 → 463
    PCI; PCI domain
    pfam10602
    Location:162 → 344
    RPN7; 26S proteasome subunit RPN7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120675086..120679928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314411.1 → XP_017169900.1  COP9 signalosome complex subunit 1 isoform X4

    Conserved Domains (2) summary
    pfam01399
    Location:319 → 423
    PCI; PCI domain
    pfam10602
    Location:123 → 304
    RPN7; 26S proteasome subunit RPN7

  2. XM_006532744.3 → XP_006532807.1  COP9 signalosome complex subunit 1 isoform X1

    Conserved Domains (2) summary
    pfam01399
    Location:359 → 463
    PCI; PCI domain
    pfam10602
    Location:162 → 344
    RPN7; 26S proteasome subunit RPN7

  3. XM_017314409.2 → XP_017169898.1  COP9 signalosome complex subunit 1 isoform X2

    Conserved Domains (2) summary
    pfam01399
    Location:358 → 462
    PCI; PCI domain
    pfam10602
    Location:162 → 343
    RPN7; 26S proteasome subunit RPN7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LD4.1 GenPept UniProtKB/Swiss-Prot:Q99LD4

Gene LinkOut

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