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Zfp710 zinc finger protein 710 [ Mus musculus (house mouse) ]

Gene ID: 209225, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp710provided by MGI
Official Full Name
zinc finger protein 710provided by MGI
Primary source
MGI:MGI:1921747
See related
Ensembl:ENSMUSG00000048897 AllianceGenome:MGI:1921747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf710; 9830165K13; 5430400N05Rik
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in early conceptus; embryo ectoderm; eye; and oocyte. Orthologous to human ZNF710 (zinc finger protein 710). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 18.4), lung adult (RPKM 17.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D2; 7 45.36 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79674581..79742498)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80024814..80092751)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5430400D12 gene Neighboring gene actin-related protein 2/3 complex inhibitor Neighboring gene predicted gene, 31966 Neighboring gene STARR-seq mESC enhancer starr_19293 Neighboring gene STARR-seq mESC enhancer starr_19295 Neighboring gene STARR-seq mESC enhancer starr_19296 Neighboring gene STARR-positive B cell enhancer ABC_E4939 Neighboring gene STARR-positive B cell enhancer ABC_E8970 Neighboring gene STARR-seq mESC enhancer starr_19297 Neighboring gene STARR-positive B cell enhancer ABC_E6561 Neighboring gene STARR-positive B cell enhancer ABC_E6562 Neighboring gene STARR-positive B cell enhancer ABC_E6563 Neighboring gene predicted gene, 21057 Neighboring gene isocitrate dehydrogenase 2 (NADP+), mitochondrial Neighboring gene STARR-seq mESC enhancer starr_19312 Neighboring gene predicted gene, 53380 Neighboring gene STARR-positive B cell enhancer ABC_E3729 Neighboring gene STARR-positive B cell enhancer ABC_E6564 Neighboring gene predicted gene 45202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 710

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145999.2 → NP_001139471.1  zinc finger protein 710 isoform a

    See identical proteins and their annotated locations for NP_001139471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC110903, AC164075
    Consensus CDS
    CCDS52280.1
    UniProtKB/Swiss-Prot
    Q3U288, Q3U341, Q3U396, Q6P9R3, Q8BJH0, Q8BTL6, Q8BZ48
    Related
    ENSMUSP00000132361.3, ENSMUST00000164056.9
    Conserved Domains (4) summary
    COG5048
    Location:418 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299 → 319
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:325 → 347
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:339 → 364
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001146000.2 → NP_001139472.1  zinc finger protein 710 isoform b

    See identical proteins and their annotated locations for NP_001139472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and includes an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC110903, AC164075
    Consensus CDS
    CCDS52279.1
    UniProtKB/Swiss-Prot
    Q3U288
    Related
    ENSMUSP00000129357.2, ENSMUST00000166250.8
    Conserved Domains (2) summary
    COG5048
    Location:337 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299 → 319
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_175433.6 → NP_780642.3  zinc finger protein 710 isoform a

    See identical proteins and their annotated locations for NP_780642.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC110903, AC164075
    Consensus CDS
    CCDS52280.1
    UniProtKB/Swiss-Prot
    Q3U288, Q3U341, Q3U396, Q6P9R3, Q8BJH0, Q8BTL6, Q8BZ48
    Related
    ENSMUSP00000050577.9, ENSMUST00000049680.10
    Conserved Domains (4) summary
    COG5048
    Location:418 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299 → 319
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:325 → 347
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:339 → 364
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79674581..79742498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242314.2 → XP_030098174.1  zinc finger protein 710 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:337 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299 → 319
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006540744.5 → XP_006540807.1  zinc finger protein 710 isoform X1

    See identical proteins and their annotated locations for XP_006540807.1

    UniProtKB/Swiss-Prot
    Q3U288, Q3U341, Q3U396, Q6P9R3, Q8BJH0, Q8BTL6, Q8BZ48
    Conserved Domains (4) summary
    COG5048
    Location:418 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299 → 319
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:325 → 347
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:339 → 364
    zf-H2C2_2; Zinc-finger double domain

  3. XM_006540742.5 → XP_006540805.1  zinc finger protein 710 isoform X1

    See identical proteins and their annotated locations for XP_006540805.1

    UniProtKB/Swiss-Prot
    Q3U288, Q3U341, Q3U396, Q6P9R3, Q8BJH0, Q8BTL6, Q8BZ48
    Conserved Domains (4) summary
    COG5048
    Location:418 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299 → 319
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:325 → 347
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:339 → 364
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006540743.5 → XP_006540806.1  zinc finger protein 710 isoform X1

    See identical proteins and their annotated locations for XP_006540806.1

    UniProtKB/Swiss-Prot
    Q3U288, Q3U341, Q3U396, Q6P9R3, Q8BJH0, Q8BTL6, Q8BZ48
    Conserved Domains (4) summary
    COG5048
    Location:418 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299 → 319
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:325 → 347
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:339 → 364
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U288.1 GenPept UniProtKB/Swiss-Prot:Q3U288

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