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Sts steroid sulfatase [ Mus musculus (house mouse) ]

Gene ID: 20905, updated on 9-Dec-2024

Summary

Official Symbol
Stsprovided by MGI
Official Full Name
steroid sulfataseprovided by MGI
Primary source
MGI:MGI:98438
See related
AllianceGenome:MGI:98438
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ArsC
Summary
Predicted to enable arylsulfatase activity and steryl-sulfatase activity. Predicted to be involved in several processes, including response to estrogen; response to pH; and response to peptide hormone. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Is expressed in several structures, including central nervous system; sensory organ; skeleton; skin; and spleen. Human ortholog(s) of this gene implicated in X-linked ichthyosis. Orthologous to human STS (steroid sulfatase). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
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Genomic context

See Sts in Genome Data Viewer
Location:
X F5; X
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (168856332..169015037, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene midline 1 Neighboring gene STARR-seq mESC enhancer starr_48290 Neighboring gene predicted gene 15247 Neighboring gene erythroid differentiation regulator 1 x Neighboring gene RIKEN cDNA 2510022D24 gene Neighboring gene neuroligin 4-like Neighboring gene A-kinase anchoring protein 17A

Genomic regions, transcripts, and products

Genomic Sequence:
NC_000086.8 Chromosome X Reference GRCm39 C57BL/6J

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arylsulfatase activity  
enables metal ion binding  
enables steryl-sulfatase activity  
enables steryl-sulfatase activity  
enables sulfuric ester hydrolase activity PubMed 
Process Evidence Code Pubs
involved_in female pregnancy  
involved_in learning or memory  
involved_in positive regulation of cell population proliferation  
involved_in response to estrogen  
involved_in response to organic cyclic compound  
involved_in response to pH  
involved_in response to peptide hormone  
involved_in steroid metabolic process  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
located_in nuclear envelope  

General protein information

Preferred Names
steryl-sulfatase
Names
ASC
arylsulfatase C
steryl-sulfate sulfohydrolase
NP_033319.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009293.1NP_033319.1  steryl-sulfatase precursor

    See identical proteins and their annotated locations for NP_033319.1

    Status: PROVISIONAL

    Source sequence(s)
    U37545
    UniProtKB/Swiss-Prot
    P50427
    Conserved Domains (2) summary
    COG3119
    Location:36530
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:36535
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    168856332..169015037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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