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Hmgcll1 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 208982, updated on 11-Apr-2024

Summary

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Official Symbol
Hmgcll1provided by MGI
Official Full Name
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1provided by MGI
Primary source
MGI:MGI:2446108
See related
Ensembl:ENSMUSG00000007908 AllianceGenome:MGI:2446108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process; leucine catabolic process; and lipid metabolic process. Predicted to be located in membrane and perinuclear region of cytoplasm. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in several structures, including blastocyst; extraembryonic component; limb; nervous system; and respiratory system. Orthologous to human HMGCLL1 (3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 3.0), frontal lobe adult (RPKM 2.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 D; 9 42.43 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75921983..76043632)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (76014698..76136350)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein 5 Neighboring gene Ex4r enhancer intronic to Bmp5 Neighboring gene STARR-seq mESC enhancer starr_24676 Neighboring gene predicted gene, 34005 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75851566-75851867 Neighboring gene STARR-seq mESC enhancer starr_24677 Neighboring gene STARR-seq mESC enhancer starr_24678 Neighboring gene STARR-seq mESC enhancer starr_24679 Neighboring gene GDNF family receptor alpha like Neighboring gene STARR-positive B cell enhancer mm9_chr9:76084472-76084773 Neighboring gene hypocretin (orexin) receptor 2 Neighboring gene STARR-seq mESC enhancer starr_24681

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
  2. Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models. Soulez M, et al. Mol Cell Biol, 2019 Mar 15. PMID 30642949, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC36512

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylglutaryl-CoA lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylglutaryl-CoA lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxo-acid-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ketone body biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ketone body biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
Names
3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1
probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
NP_001397098.1
NP_001397099.1
NP_001397100.1
NP_776092.1
XP_006511012.1
XP_011240998.1
XP_036010667.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410169.1 → NP_001397098.1  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC079244

  2. NM_001410170.1 → NP_001397099.1  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC079244

  3. NM_001410171.1 → NP_001397100.1  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC079244

  4. NM_173731.3 → NP_776092.1  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_776092.1

    Status: VALIDATED

    Source sequence(s)
    AC079244
    Consensus CDS
    CCDS23349.1
    UniProtKB/Swiss-Prot
    Q8JZS7
    UniProtKB/TrEMBL
    D3YVU9
    Related
    ENSMUSP00000008052.7, ENSMUST00000008052.13
    Conserved Domains (1) summary
    PLN02746
    Location:26 → 336
    PLN02746; hydroxymethylglutaryl-CoA lyase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75921983..76043632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510949.4 → XP_006511012.1  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic isoform X5

    Conserved Domains (1) summary
    cd07938
    Location:50 → 265
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain

  2. XM_011242696.3 → XP_011240998.1  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic isoform X3

    Conserved Domains (1) summary
    cd07938
    Location:50 → 266
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain

  3. XM_036154774.1 → XP_036010667.1  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic isoform X4

    Conserved Domains (1) summary
    cd07938
    Location:50 → 265
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZS7.1 GenPept UniProtKB/Swiss-Prot:Q8JZS7

Gene LinkOut

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