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Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif 18 [ Mus musculus (house mouse) ]

Gene ID: 208936, updated on 11-Apr-2024

Summary

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Official Symbol
Adamts18provided by MGI
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 18provided by MGI
Primary source
MGI:MGI:2442600
See related
Ensembl:ENSMUSG00000053399 AllianceGenome:MGI:2442600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADAMTS21; 9630038L21; E130314N14Rik
Summary
Predicted to enable metalloendopeptidase activity. Acts upstream of or within negative regulation of platelet aggregation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including alimentary system; brain; eye; lung; and male reproductive gland or organ. Orthologous to human ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 1.9), CNS E18 (RPKM 1.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 59.65 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (114423755..114575975, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (113697123..113849343, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene MON1 homolog B, secretory traffciking associated Neighboring gene synaptonemal complex central element protein 1 like Neighboring gene predicted gene, 30052 Neighboring gene STARR-seq mESC enhancer starr_22763 Neighboring gene predicted gene, 30107 Neighboring gene STARR-seq mESC enhancer starr_22765 Neighboring gene STARR-positive B cell enhancer ABC_E9028 Neighboring gene nudix hydrolase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice. Lin X, et al. Reprod Biol, 2021 Sep. PMID 34388417
  2. ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice. Lin X, et al. Reprod Biol, 2021 Sep. PMID 34271244
  3. Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice. Dang S, et al. Biochem Biophys Res Commun, 2018 Feb 19. PMID 29421655
  4. A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 Deficiency Leads to Visceral Adiposity and Associated Metabolic Syndrome in Mice. Zhu R, et al. Am J Pathol, 2018 Feb. PMID 29169989
  5. The development of monoclonal anti-ADAMTS18 antibodies with precise validation of ADAMTS18 post-translational modification status in living organisms. Zhu R, et al. Biochem Biophys Res Commun, 2017 Oct 21. PMID 28843853

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis.
    Title: ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis.
  2. ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice.
    Title: ADAMTS18 regulates early branching morphogenesis of lacrimal gland and has a significant association with the risk of dry eye in mice.
  3. Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.
    Title: Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.
  4. ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice.
    Title: ADAMTS18 deficiency leads to preputial gland hypoplasia and fibrosis in male mice.
  5. ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice.
    Title: ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice.
  6. Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system.
    Title: Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system.
  7. Adamts18 links luminal hormone receptor signaling to basement membrane remodeling and stem cell activation.
    Title: The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche.
  8. The underlying molecular mechanisms could be attributed in part to the abnormal vascular remodeling, including deficiency of carotid body (glomus) and aberrant carotid basal lamina. These results indicate a novel function of ADAMTS18 in vascular remodeling and associated thrombus formation.
    Title: Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice.
  9. Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/beta-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in a mouse model.
    Title: Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer.
  10. these data demonstrate a thrombin cleavage site and confirm a short form of ADAMTS-18 presents in vivo.
    Title: Identification of a thrombin cleavage site and a short form of ADAMTS-18.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eye development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 18
Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403922.1 → NP_001390851.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC108856, AC125463

  2. NM_001403923.1 → NP_001390852.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC108856, AC125463

  3. NM_001403924.1 → NP_001390853.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC108856, AC125463

  4. NM_172466.4 → NP_766054.2  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform a precursor

    See identical proteins and their annotated locations for NP_766054.2

    Status: VALIDATED

    Source sequence(s)
    AC108856, AC125463
    Consensus CDS
    CCDS40485.1
    UniProtKB/Swiss-Prot
    E9QNK0, Q4VC17, Q8BZD1
    UniProtKB/TrEMBL
    B7ZMV1
    Related
    ENSMUSP00000090801.5, ENSMUST00000093113.5
    Conserved Domains (7) summary
    smart00209
    Location:592 → 644
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:293 → 494
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:749 → 861
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:65 → 203
    Pep_M12B_propep; Reprolysin family propeptide
    pfam08686
    Location:1186 → 1216
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:511 → 578
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:935 → 991
    TSP1_ADAMTS; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    114423755..114575975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530797.2 → XP_006530860.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X3

    See identical proteins and their annotated locations for XP_006530860.1

    UniProtKB/TrEMBL
    B7ZMV1
    Conserved Domains (6) summary
    smart00209
    Location:512 → 564
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:213 → 414
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:80 → 123
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:669 → 781
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1106 → 1136
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:431 → 498
    ADAM_CR_2; ADAM cysteine-rich domain

  2. XM_006530795.4 → XP_006530858.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1

    UniProtKB/TrEMBL
    B7ZMV1
    Conserved Domains (6) summary
    smart00209
    Location:626 → 678
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:327 → 528
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:99 → 237
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:783 → 895
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1220 → 1250
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:545 → 612
    ADAM_CR_2; ADAM cysteine-rich domain

  3. XM_030243369.1 → XP_030099229.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X5

    Conserved Domains (5) summary
    smart00209
    Location:180 → 232
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:337 → 449
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:774 → 804
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:99 → 166
    ADAM_CR_2; ADAM cysteine-rich domain
    cl00064
    Location:1 → 82
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

  4. XM_030243370.1 → XP_030099230.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X5

    Conserved Domains (5) summary
    smart00209
    Location:180 → 232
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:337 → 449
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:774 → 804
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:99 → 166
    ADAM_CR_2; ADAM cysteine-rich domain
    cl00064
    Location:1 → 82
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

  5. XM_017312629.2 → XP_017168118.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X2

    UniProtKB/TrEMBL
    B7ZMV1
    Conserved Domains (6) summary
    smart00209
    Location:548 → 600
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:249 → 450
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:116 → 159
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:705 → 817
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1142 → 1172
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:467 → 534
    ADAM_CR_2; ADAM cysteine-rich domain

  6. XM_006530801.4 → XP_006530864.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X4

    See identical proteins and their annotated locations for XP_006530864.1

    UniProtKB/TrEMBL
    Q8BKA1
    Conserved Domains (5) summary
    smart00209
    Location:420 → 472
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:121 → 322
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:577 → 689
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1014 → 1044
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:339 → 406
    ADAM_CR_2; ADAM cysteine-rich domain

  7. XM_017312631.2 → XP_017168120.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X6

    Conserved Domains (4) summary
    smart00209
    Location:626 → 678
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:327 → 528
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:99 → 237
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:545 → 612
    ADAM_CR_2; ADAM cysteine-rich domain

RNA

  1. XR_001778416.2 RNA Sequence

  2. XR_004934786.1 RNA Sequence

  3. XR_878788.3 RNA Sequence

  4. XR_001778415.2 RNA Sequence

  5. XR_004934785.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VC17.2 GenPept UniProtKB/Swiss-Prot:Q4VC17

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