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Cenpx centromere protein X [ Mus musculus (house mouse) ]

Gene ID: 20892, updated on 5-Mar-2024

Summary

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Official Symbol
Cenpxprovided by MGI
Official Full Name
centromere protein Xprovided by MGI
Primary source
MGI:MGI:894324
See related
Ensembl:ENSMUSG00000025144 AllianceGenome:MGI:894324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stra13
Summary
Predicted to enable DNA binding activity. Predicted to contribute to double-stranded DNA binding activity. Predicted to be involved in replication fork processing and resolution of meiotic recombination intermediates. Predicted to act upstream of or within cell division and cellular response to DNA damage stimulus. Predicted to be located in kinetochore and nucleus. Predicted to be part of FANCM-MHF complex and Fanconi anaemia nuclear complex. Is expressed in mammary gland epithelium. Orthologous to human CENPX (centromere protein X). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 16.5), adrenal adult (RPKM 12.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cenpx in Genome Data Viewer
Location:
11 E2; 11 84.45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120601768..120604721, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120710941..120713895, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene notum palmitoleoyl-protein carboxylesterase Neighboring gene STARR-seq mESC enhancer starr_31365 Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing Neighboring gene STARR-positive B cell enhancer ABC_E472 Neighboring gene leucine rich repeat containing 45 Neighboring gene STARR-positive B cell enhancer ABC_E10737 Neighboring gene Rac family small GTPase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor. St-Pierre B, et al. Gene Expr Patterns, 2004 Dec. PMID 15567721
  2. Stra13 homodimers repress transcription through class B E-box elements. St-Pierre B, et al. J Biol Chem, 2002 Nov 29. PMID 12297495
  3. E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha. Scott LM, et al. Blood, 1996 Oct 1. PMID 8839844
  4. Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. Du X, et al. PLoS One, 2014. PMID 24595170, Free PMC Article
  5. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
involved_in kinetochore assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in resolution of meiotic recombination intermediates ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of FANCM-MHF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of FANCM-MHF complex ISO
Inferred from Sequence Orthology
more info
  
part_of Fanconi anaemia nuclear complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Fanconi anaemia nuclear complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein X
Names
CENP-X
FANCM-interacting histone fold protein 2
Fanconi anemia-associated polypeptide of 10 kDa
immediate-early-response protein D9
retinoic acid-inducible gene D9 protein
stimulated by retinoic acid 13
stimulated by retinoic acid gene 13 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347611.2 → NP_001334540.1  centromere protein X isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663030
    Consensus CDS
    CCDS83948.1
    UniProtKB/Swiss-Prot
    Q8C4X1
    Related
    ENSMUSP00000026137.8, ENSMUST00000026137.8

  2. NM_001347612.2 → NP_001334541.1  centromere protein X isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663030
    Consensus CDS
    CCDS83947.1
    UniProtKB/TrEMBL
    A2AC07
    Related
    ENSMUSP00000101760.2, ENSMUST00000106154.8
    Conserved Domains (1) summary
    pfam09415
    Location:46 → 113
    CENP-X; CENP-S associating Centromere protein X

  3. NM_001425441.1 → NP_001412370.1  centromere protein X isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL663030

  4. NM_001425443.1 → NP_001412372.1  centromere protein X isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL663030

  5. NM_001425444.1 → NP_001412373.1  centromere protein X isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL663030

  6. NM_001425445.1 → NP_001412374.1  centromere protein X isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL663030

  7. NM_001425447.1 → NP_001412376.1  centromere protein X isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL663030
    UniProtKB/TrEMBL
    A2AC07

  8. NM_001425449.1 → NP_001412378.1  centromere protein X isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL663030

  9. NM_001425451.1 → NP_001412380.1  centromere protein X isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL663030

  10. NM_001425452.1 → NP_001412381.1  centromere protein X isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL663030

  11. NM_001425453.1 → NP_001412382.1  centromere protein X isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL663030

  12. NM_001425454.1 → NP_001412383.1  centromere protein X isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL663030

  13. NM_001425455.1 → NP_001412384.1  centromere protein X isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL663030

  14. NM_001425457.1 → NP_001412386.1  centromere protein X isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL663030

  15. NM_016665.3 → NP_057874.2  centromere protein X isoform 1

    See identical proteins and their annotated locations for NP_057874.2

    Status: VALIDATED

    Source sequence(s)
    AL663030
    Consensus CDS
    CCDS49009.1
    UniProtKB/Swiss-Prot
    A2AC08, O08693, O08694, O08695, Q8BPD7, Q8C4X1
    Related
    ENSMUSP00000050335.7, ENSMUST00000055424.13
    Conserved Domains (1) summary
    pfam09415
    Location:9 → 77
    CENP-X; CENP-S associating Centromere protein X

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120601768..120604721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248853.3 → XP_011247155.2  centromere protein X isoform X6

    Conserved Domains (1) summary
    pfam09415
    Location:89 → 122
    CENP-X; CENP-S associating Centromere protein X

  2. XM_011248850.3 → XP_011247152.2  centromere protein X isoform X3

  3. XM_006532729.3 → XP_006532792.3  centromere protein X isoform X5

  4. XM_011248852.3 → XP_011247154.2  centromere protein X isoform X2

  5. XM_011248848.1 → XP_011247150.1  centromere protein X isoform X1

    See identical proteins and their annotated locations for XP_011247150.1

    Conserved Domains (1) summary
    pfam09415
    Location:46 → 79
    CENP-X; CENP-S associating Centromere protein X
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C4X1.1 GenPept UniProtKB/Swiss-Prot:Q8C4X1

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