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Ccdc62 coiled-coil domain containing 62 [ Mus musculus (house mouse) ]

Gene ID: 208908, updated on 25-Apr-2024

Summary

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Official Symbol
Ccdc62provided by MGI
Official Full Name
coiled-coil domain containing 62provided by MGI
Primary source
MGI:MGI:2684996
See related
Ensembl:ENSMUSG00000061882 AllianceGenome:MGI:2684996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm150; repro29; G1-485-3
Summary
Predicted to enable estrogen receptor binding activity and nuclear receptor coactivator activity. Acts upstream of or within blastocyst hatching. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in early conceptus and secondary oocyte. Orthologous to human CCDC62 (coiled-coil domain containing 62). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 17.0), bladder adult (RPKM 2.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 63.28 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124068683..124107958)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123930425..123969895)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene hydrocarboxylic acid receptor 1 Neighboring gene STARR-seq mESC enhancer starr_14329 Neighboring gene STARR-positive B cell enhancer ABC_E4789 Neighboring gene density-regulated protein Neighboring gene STARR-positive B cell enhancer ABC_E6379 Neighboring gene STARR-seq mESC enhancer starr_14330 Neighboring gene STARR-positive B cell enhancer mm9_chr5:124397405-124397706 Neighboring gene STARR-positive B cell enhancer ABC_E6380 Neighboring gene STARR-positive B cell enhancer ABC_E1689 Neighboring gene predicted gene, 46922 Neighboring gene huntingtin interacting protein 1 related Neighboring gene microRNA 7032

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A nonsense mutation in Ccdc62 gene is responsible for spermiogenesis defects and male infertility in repro29/repro29 mice. Li Y, et al. Biol Reprod, 2017 Mar 1. PMID 28339613
  2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  3. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. required for maintenance for normal spermiogenesis and male fertility
    Title: A nonsense mutation in Ccdc62 gene is responsible for spermiogenesis defects and male infertility in repro29/repro29 mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Chemically induced (ENU) (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134767.1 → NP_001128239.1  coiled-coil domain-containing protein 62

    See identical proteins and their annotated locations for NP_001128239.1

    Status: VALIDATED

    Source sequence(s)
    AC122753
    Consensus CDS
    CCDS51646.1
    UniProtKB/Swiss-Prot
    E9PVD1, F6WEA5
    Related
    ENSMUSP00000091878.4, ENSMUST00000094320.11
    Conserved Domains (1) summary
    COG1196
    Location:57 → 353
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124068683..124107958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530268.4 → XP_006530331.1  coiled-coil domain-containing protein 62 isoform X10

    See identical proteins and their annotated locations for XP_006530331.1

    Conserved Domains (1) summary
    COG1196
    Location:65 → 330
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_030254332.2 → XP_030110192.1  coiled-coil domain-containing protein 62 isoform X13

    Conserved Domains (1) summary
    COG1196
    Location:53 → 312
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_006530269.4 → XP_006530332.1  coiled-coil domain-containing protein 62 isoform X10

    See identical proteins and their annotated locations for XP_006530332.1

    Conserved Domains (1) summary
    COG1196
    Location:65 → 330
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_006530266.5 → XP_006530329.1  coiled-coil domain-containing protein 62 isoform X9

    Conserved Domains (1) summary
    COG1196
    Location:65 → 330
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_006530271.5 → XP_006530334.1  coiled-coil domain-containing protein 62 isoform X11

    Conserved Domains (1) summary
    COG1196
    Location:57 → 330
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  6. XM_006530273.4 → XP_006530336.1  coiled-coil domain-containing protein 62 isoform X12

    See identical proteins and their annotated locations for XP_006530336.1

    Conserved Domains (1) summary
    COG1196
    Location:57 → 330
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_006530274.4 → XP_006530337.1  coiled-coil domain-containing protein 62 isoform X12

    See identical proteins and their annotated locations for XP_006530337.1

    Conserved Domains (1) summary
    COG1196
    Location:57 → 330
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. XM_006530260.5 → XP_006530323.1  coiled-coil domain-containing protein 62 isoform X5

    Conserved Domains (1) summary
    COG1196
    Location:57 → 353
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  9. XM_017320780.3 → XP_017176269.1  coiled-coil domain-containing protein 62 isoform X5

    Conserved Domains (1) summary
    COG1196
    Location:57 → 353
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  10. XM_006530255.5 → XP_006530318.1  coiled-coil domain-containing protein 62 isoform X1

    See identical proteins and their annotated locations for XP_006530318.1

    UniProtKB/Swiss-Prot
    E9PVD1, F6WEA5
    Conserved Domains (1) summary
    COG1196
    Location:57 → 353
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  11. XM_006530258.5 → XP_006530321.1  coiled-coil domain-containing protein 62 isoform X3

    Conserved Domains (1) summary
    TIGR02168
    Location:39 → 344
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. XM_036164964.1 → XP_036020857.1  coiled-coil domain-containing protein 62 isoform X1

    UniProtKB/Swiss-Prot
    E9PVD1, F6WEA5
    Conserved Domains (1) summary
    COG1196
    Location:57 → 353
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  13. XM_006530261.5 → XP_006530324.1  coiled-coil domain-containing protein 62 isoform X6

    Conserved Domains (1) summary
    COG1196
    Location:95 → 353
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  14. XM_006530257.5 → XP_006530320.1  coiled-coil domain-containing protein 62 isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:52 → 335
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  15. XM_006530259.5 → XP_006530322.1  coiled-coil domain-containing protein 62 isoform X4

    Conserved Domains (1) summary
    COG1196
    Location:59 → 319
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  16. XM_030254331.1 → XP_030110191.1  coiled-coil domain-containing protein 62 isoform X7

    Conserved Domains (1) summary
    COG1196
    Location:42 → 150
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  17. XM_006530263.5 → XP_006530326.1  coiled-coil domain-containing protein 62 isoform X8

RNA

  1. XR_001784651.3 RNA Sequence

  2. XR_001784652.3 RNA Sequence

  3. XR_004942476.1 RNA Sequence

  4. XR_001784655.3 RNA Sequence

  5. XR_001784654.3 RNA Sequence

  6. XR_001784653.3 RNA Sequence

  7. XR_003955611.2 RNA Sequence

  8. XR_001784649.3 RNA Sequence

  9. XR_387558.5 RNA Sequence

  10. XR_001784650.3 RNA Sequence

  11. XR_004942475.1 RNA Sequence

  12. XR_003955610.2 RNA Sequence

  13. XR_001784648.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PVD1.1 GenPept UniProtKB/Swiss-Prot:E9PVD1

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