Aurka aurora kinase A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aurkaprovided by MGI
Official Full Name: aurora kinase Aprovided by MGI
Primary source: MGI:MGI:894678
See related: Ensembl:ENSMUSG00000027496 AllianceGenome:MGI:894678
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; ARK-1; Aurora-A
Summary: Enables histone serine kinase activity and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including microtubule cytoskeleton organization; positive regulation of oocyte maturation; and protein localization to centrosome. Located in axon hillock; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; bone; brain; eye; and genitourinary system. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14.5 (RPKM 39.2), liver E14 (RPKM 37.7) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 94.84 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (172198116..172212825, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (172356190..172370886, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERbeta.
Title: AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERβ.
eEF1A2 promotes PTEN-GSK3beta-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer.
Title: eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer.
Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1.
Title: Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1.
Deletion of Aurora kinase A prevents the development of polycystic kidney disease in mice.
Title: Deletion of Aurora kinase A prevents the development of polycystic kidney disease in mice.
Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression.
Title: Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression.
BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis.
Title: BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis.
Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes.
Title: Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes.
Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway.
Title: Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway.
Aurora A Kinase (AURKA) is required for male germline maintenance and regulates sperm motility in the mouse.
Title: Aurora A Kinase (AURKA) is required for male germline maintenance and regulates sperm motility in the mouse.
Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.
Title: Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (9) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136493 (e-PCR)
- UniSTS:210476

AW539821 (e-PCR)
- UniSTS:178783

Aurka (e-PCR), detects polymorphism
- UniSTS:530824

Aurka (e-PCR), detects polymorphism
- UniSTS:530825

Aurka (e-PCR), detects polymorphism
- UniSTS:527267

U69106 (e-PCR)
- UniSTS:163305

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within centrosome cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver regeneration	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic centrosome separation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mitotic centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of spindle checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within spindle assembly involved in female meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon hillock	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in germinal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule organizing center	IGI Inferred from Genetic Interaction more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed
located_in pronucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with spindle microtubule	ISO Inferred from Sequence Orthology more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aurora kinase A

Names: aurora 2; aurora A; aurora family kinase 1; aurora-related kinase 1; aurora/IPL1-related kinase 1; ipl1- and aurora-related kinase 1; serine/threonine kinase 6; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase Ayk1; serine/threonine-protein kinase aurora-A

NP_001278114.1

EC 2.7.11.1

NP_001408052.1

EC 2.7.11.1

NP_001408053.1

EC 2.7.11.1

NP_001408054.1

EC 2.7.11.1

NP_001408055.1

EC 2.7.11.1

NP_001408056.1

EC 2.7.11.1

NP_035627.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291185.2 → NP_001278114.1 aurora kinase A isoform b

See identical proteins and their annotated locations for NP_001278114.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in its 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 and 4 both encode the same isoform (b).

Source sequence(s)

AL833787, AL844162

Consensus CDS

CCDS71204.1

UniProtKB/Swiss-Prot

O35624, P97477, Q8C3H8, Q91YU4

UniProtKB/TrEMBL

Q3TEY6, Q7TNK2

Related

ENSMUSP00000104768.4, ENSMUST00000109140.10

Conserved Domains (1) summary

cl21453
Location:118 → 374

PKc_like; Protein Kinases, catalytic domain
NM_001421123.1 → NP_001408052.1 aurora kinase A isoform c

Status: VALIDATED

Source sequence(s)

AL833787, AL844162
NM_001421124.1 → NP_001408053.1 aurora kinase A isoform b

Status: VALIDATED

Source sequence(s)

AL833787, AL844162

UniProtKB/Swiss-Prot

O35624, P97477, Q8C3H8, Q91YU4

UniProtKB/TrEMBL

Q3TEY6
NM_001421125.1 → NP_001408054.1 aurora kinase A isoform d

Status: VALIDATED

Source sequence(s)

AL833787, AL844162
NM_001421126.1 → NP_001408055.1 aurora kinase A isoform e

Status: VALIDATED

Source sequence(s)

AL833787, AL844162
NM_001421127.1 → NP_001408056.1 aurora kinase A isoform f

Status: VALIDATED

Source sequence(s)

AL833787, AL844162
NM_011497.5 → NP_035627.1 aurora kinase A isoform a

See identical proteins and their annotated locations for NP_035627.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AL833787, AL844162

Consensus CDS

CCDS17129.1

UniProtKB/TrEMBL

Q7TNK2

Related

ENSMUSP00000028997.8, ENSMUST00000028997.8

Conserved Domains (2) summary

smart00220
Location:146 → 396

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14116
Location:140 → 396

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase