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Slk STE20-like kinase [ Mus musculus (house mouse) ]

Gene ID: 20874, updated on 11-Apr-2024

Summary

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Official Symbol
Slkprovided by MGI
Official Full Name
STE20-like kinaseprovided by MGI
Primary source
MGI:MGI:103241
See related
Ensembl:ENSMUSG00000025060 AllianceGenome:MGI:103241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9A2; Etk4; SMAK; Stk2; mSLK; mKIAA0204
Summary
Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Involved in regulation of cell migration. Located in cell leading edge. Is expressed in several structures, including alimentary system; eye; genitourinary system; muscle tissue; and nervous system. Orthologous to human SLK (STE20 like kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 14.8), placenta adult (RPKM 11.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slk in Genome Data Viewer
Location:
19 C3- D1; 19 39.77 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47568458..47633685)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47580019..47645246)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46363 Neighboring gene predicted gene, 41858 Neighboring gene STN1, CST complex subunit Neighboring gene predicted gene, 19557 Neighboring gene STARR-positive B cell enhancer ABC_E5709 Neighboring gene STARR-seq mESC enhancer starr_46366 Neighboring gene predicted gene 16068 Neighboring gene collagen, type XVII, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_46367 Neighboring gene predicted gene, 26085

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ste20-like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes. Song K, et al. Cell Prolif, 2023 Apr. PMID 36579845, Free PMC Article
  2. Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy. Schoch S, et al. J Neurosci, 2021 Sep 29. PMID 34400520, Free PMC Article
  3. Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers. Al-Zahrani KN, et al. Oncogene, 2020 Jun. PMID 32393835
  4. Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice. Woychyshyn B, et al. Am J Physiol Renal Physiol, 2020 Jun 1. PMID 32308020
  5. Ste20-like kinase, SLK, a novel mediator of podocyte integrity. Cybulsky AV, et al. Am J Physiol Renal Physiol, 2018 Jul 1. PMID 29187370, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of the Ste20-like kinase SLK in podocyte adhesion.
    Title: Role of the Ste20-like kinase SLK in podocyte adhesion.
  2. Ste20-like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes.
    Title: Ste20-like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes.
  3. Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy.
    Title: Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy.
  4. Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.
    Title: Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.
  5. Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers.
    Title: Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers.
  6. Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice.
    Title: Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice.
  7. Podocyte-specific deletion of SLK leads to albuminuria, loss of podocytes, and morphological evidence of podocyte injury. Thus, SLK is essential to the maintenance of podocyte integrity.
    Title: Ste20-like kinase, SLK, a novel mediator of podocyte integrity.
  8. Loss of SLK impairs myofiber stability and function.
    Title: Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.
  9. kinases, including Slk, Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
    Title: A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.
  10. activation of SLK by haptotactic signals requires its recruitment to the leading edge by LMO4 in a Src-dependent manner.
    Title: Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
STE20-like serine/threonine-protein kinase
Names
STE20-related kinase SMAK
STE20-related serine/threonine-protein kinase
serine/threonine-protein kinase 2
NP_001158111.1
NP_033315.2
XP_006526890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164639.1 → NP_001158111.1  STE20-like serine/threonine-protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001158111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC125075, AK029491, AK037798, AK051969, CD740818, CO431234
    Consensus CDS
    CCDS50465.1
    UniProtKB/TrEMBL
    A2RRK3
    Related
    ENSMUSP00000026043.6, ENSMUST00000026043.12
    Conserved Domains (3) summary
    smart00220
    Location:34 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28 → 309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:987 → 1127
    PKK; Polo kinase kinase

  2. NM_009289.3 → NP_033315.2  STE20-like serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_033315.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC125075, AK029491, AK037798, AK051969, CA535951, CD740818, CF748583, CO431234
    Consensus CDS
    CCDS38017.1
    UniProtKB/Swiss-Prot
    A2RRK4, O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41
    Related
    ENSMUSP00000049977.8, ENSMUST00000051691.8
    Conserved Domains (3) summary
    smart00220
    Location:34 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06643
    Location:28 → 309
    STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
    pfam12474
    Location:1018 → 1158
    PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    47568458..47633685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526827.5 → XP_006526890.1  STE20-like serine/threonine-protein kinase isoform X1

    Conserved Domains (3) summary
    PTZ00121
    Location:284 → 1112
    PTZ00121; MAEBL; Provisional
    pfam12474
    Location:942 → 1082
    PKK; Polo kinase kinase
    cl21453
    Location:1 → 233
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54988.2 GenPept UniProtKB/Swiss-Prot:O54988

Gene LinkOut

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