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Eif5a2 eukaryotic translation initiation factor 5A2 [ Mus musculus (house mouse) ]

Gene ID: 208691, updated on 21-Apr-2024

Summary

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Official Symbol
Eif5a2provided by MGI
Official Full Name
eukaryotic translation initiation factor 5A2provided by MGI
Primary source
MGI:MGI:1933735
See related
Ensembl:ENSMUSG00000050192 AllianceGenome:MGI:1933735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
eIF5AII; 9630038B20
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in positive regulation of translational elongation. Predicted to act upstream of or within mRNA transport and protein transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of nuclear pore. Orthologous to human EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 10.7), cortex adult (RPKM 6.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 A3; 3 12.25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (28835426..28852995)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (28781032..28798846)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700112D23 gene Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 2 Neighboring gene predicted pseudogene 6505 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:28679958-28680067 Neighboring gene predicted gene, 32950 Neighboring gene STARR-positive B cell enhancer ABC_E6046 Neighboring gene ribosomal protein L22 like 1 Neighboring gene predicted gene, 33051

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance. Xu G, et al. Cell Death Dis, 2022 Aug 5. PMID 35931669, Free PMC Article
  2. New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape. Schultz CR, et al. Biol Open, 2023 Mar 15. PMID 36848144, Free PMC Article
  3. Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. Chen M, et al. BMC Cancer, 2011 May 26. PMID 21612665, Free PMC Article
  4. Biological Relevance and Therapeutic Potential of the Hypusine Modification System. Pällmann N, et al. J Biol Chem, 2015 Jul 24. PMID 26037925, Free PMC Article
  5. Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media. Parkinson N, et al. PLoS Genet, 2006 Oct 6. PMID 17029558, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2.
    Title: microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2.
  2. A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates beta-Cell Identity and Function.
    Title: A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates β-Cell Identity and Function.
  3. New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape.
    Title: New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape.
  4. Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance.
    Title: Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance.
  5. activation of eIF-5A2 repressed p19 level and therefore destabilized p53 in transgenic mouse embryo fibroblast (MEF) cells. This subsequently allowed for the accumulation of chromosomal instability.
    Title: Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability.
  6. Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys 50. Mouse EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and eIF5AII.
    Title: Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124092, MGC124093

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translational termination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 5A-2
Names
eukaryotic initiation factor 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177586.6 → NP_808254.1  eukaryotic translation initiation factor 5A-2

    See identical proteins and their annotated locations for NP_808254.1

    Status: VALIDATED

    Source sequence(s)
    AC122490
    Consensus CDS
    CCDS17277.1
    UniProtKB/Swiss-Prot
    Q8BGY2
    Related
    ENSMUSP00000050289.8, ENSMUST00000060500.9
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    28835426..28852995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGY2.3 GenPept UniProtKB/Swiss-Prot:Q8BGY2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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