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Stk10 serine/threonine kinase 10 [ Mus musculus (house mouse) ]

Gene ID: 20868, updated on 11-Apr-2024

Summary

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Official Symbol
Stk10provided by MGI
Official Full Name
serine/threonine kinase 10provided by MGI
Primary source
MGI:MGI:1099439
See related
Ensembl:ENSMUSG00000020272 AllianceGenome:MGI:1099439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lok; Gek1; mKIAA4026
Summary
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen adult (RPKM 37.1), testis adult (RPKM 17.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Stk10 in Genome Data Viewer
Location:
11 18.97 cM; 11 A4
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32483266..32574595)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32533266..32624595)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:32442680-32442833 Neighboring gene EF-hand calcium binding domain 9 Neighboring gene STARR-positive B cell enhancer ABC_E5214 Neighboring gene F-box and WD-40 domain protein 11 Neighboring gene STARR-seq mESC enhancer starr_29115 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. Kuramochi S, et al. J Biol Chem, 1997 Sep 5. PMID 9278426
  2. A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870. Edgar AJ, et al. Biosci Rep, 2014 Feb 1. PMID 27919044, Free PMC Article
  3. Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. Kuramochi S, et al. Immunogenetics, 1999 May. PMID 10199912
  4. Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. Endo J, et al. FEBS Lett, 2000 Feb 25. PMID 10692593
  5. A novel serine/threonine kinase gene, Gek1, is expressed in meiotic testicular germ cells and primordial germ cells. Yanagisawa M, et al. Mol Reprod Dev, 1996 Dec. PMID 8956278

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. kinases, including Slk, Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
    Title: A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.
  2. These studies identify a new ERM kinase of importance in lymphocytes and confirm the role of ezrin-radixin-moesin phosphorylation in regulating cell shape and motility.
    Title: LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.
  3. Stk10 is a novel polo-like kinase kinase that cooperates with hSlk to regulate Plk1 function in human cells
    Title: Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4026

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in lymphocyte aggregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lymphocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lymphocyte migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 10
Names
germ cell kinase 1
lymphocyte-oriented kinase
NP_001346106.1
NP_001346107.1
NP_033314.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359177.1 → NP_001346106.1  serine/threonine-protein kinase 10 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AL669844, BC096624

  2. NM_001359178.1 → NP_001346107.1  serine/threonine-protein kinase 10 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 3, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK148118, AL669844, BC096624, BY207613

  3. NM_009288.2 → NP_033314.2  serine/threonine-protein kinase 10 isoform 1

    See identical proteins and their annotated locations for NP_033314.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA182088, AL669844, BC096624, BC128363, BY207613
    Consensus CDS
    CCDS24529.1
    UniProtKB/Swiss-Prot
    B1ATW8, O55098
    UniProtKB/TrEMBL
    A1A553
    Related
    ENSMUSP00000099885.4, ENSMUST00000102821.4
    Conserved Domains (3) summary
    cd06644
    Location:23 → 314
    STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)
    smart00220
    Location:36 → 294
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12474
    Location:754 → 894
    PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    32483266..32574595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55098.2 GenPept UniProtKB/Swiss-Prot:O55098

Gene LinkOut

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