Stip1 stress-induced phosphoprotein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stip1provided by MGI
Official Full Name: stress-induced phosphoprotein 1provided by MGI
Primary source: MGI:MGI:109130
See related: Ensembl:ENSMUSG00000024966 AllianceGenome:MGI:109130
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hop; p60; Sti1
Summary: Predicted to enable chaperone binding activity; heat shock protein binding activity; and protein C-terminus binding activity. Acts upstream of or within cellular response to interleukin-7. Located in myelin sheath. Is expressed in several structures, including central nervous system; liver; lung; metanephros; and notochord. Orthologous to human STIP1 (stress induced phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 77.9), placenta adult (RPKM 65.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.15 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6998064..7017394, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (7020696..7040026, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of alpha-synuclein in vivo.
Title: Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.
Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
Title: Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co-chaperone STI1.
Title: Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co-chaperone STI1.
Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrP(C) signaling.
Title: Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrP(C) signaling.
Our experiments reveal that STI1 activates multiple signaling pathways that cooperate to increase neuronal resilience in neurons subjected to ischemic insult.
Title: Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.
These results indicate that PrPC mutations impair cellular functions mediated by the wild-type protein in conjunction with STI1 in neural cells, supporting the hypothesis of a PrPC loss-of-function mechanism linked to prion disease.
Title: Loss of STI1-mediated neuronal survival and differentiation in disease-associated mutations of prion protein.
In conclusion, STIP1 is upregulated in HCC and associated with poor clinical prognosis. Blocking STIP1 activity suppresses HCC cell growth, providing the rationale for STIP1 as a potential therapeutic target in HCC.
Title: Autocrine STIP1 signaling promotes tumor growth and is associated with disease outcome in hepatocellular carcinoma.
Domains of STIP1 responsible for regulating PrPC-dependent amyloid-beta oligomer toxicity
Title: Domains of STIP1 responsible for regulating PrPC-dependent amyloid-β oligomer toxicity.
Reduced STIP1 levels can contribute to phenotypes related to hyperactivity and attention deficits.
Title: Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1).
We correlate the expression of STI1 and glioma progression, and suggest that STI1 expression in microglia/macrophages and infiltrating lymphocytes is modulated by the brain tumor microenvironment.
Title: Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U27830 (e-PCR)
- UniSTS:160785

NoName (e-PCR)
- UniSTS:237863

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to interleukin-7	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in myelin sheath	HDA more info	PubMed
is_active_in nucleus	IPI Inferred from Physical Interaction more info	PubMed
part_of protein folding chaperone complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stress-induced-phosphoprotein 1

Names: Hsp70/Hsp90 organizing protein; IEF SSP 3521; hsc70/Hsp90-organizing protein; mSTI1; stress-inducible protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016737.2 → NP_058017.1 stress-induced-phosphoprotein 1

See identical proteins and their annotated locations for NP_058017.1

Status: VALIDATED

Source sequence(s)

AK167273, BY387498, CJ155828

Consensus CDS

CCDS37901.1

UniProtKB/Swiss-Prot

Q3TT16, Q60864, Q8BPH3, Q99L66

UniProtKB/TrEMBL

Q3THQ5

Related

ENSMUSP00000025918.8, ENSMUST00000025918.9

Conserved Domains (6) summary

smart00727
Location:492 → 531

STI1; Heat shock chaperonin-binding motif

smart00028
Location:300 → 328

TPR; Tetratricopeptide repeats

sd00006
Location:364 → 388

TPR; TPR repeat [structural motif]

pfam00515
Location:394 → 427

TPR_1; Tetratricopeptide repeat

pfam13414
Location:360 → 425

TPR_11; TPR repeat

pfam13424
Location:255 → 328

TPR_12; Tetratricopeptide repeat