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Slc25a38 solute carrier family 25, member 38 [ Mus musculus (house mouse) ]

Gene ID: 208638, updated on 2-May-2024

Summary

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Official Symbol
Slc25a38provided by MGI
Official Full Name
solute carrier family 25, member 38provided by MGI
Primary source
MGI:MGI:2384782
See related
Ensembl:ENSMUSG00000032519 AllianceGenome:MGI:2384782
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
appoptosin
Summary
Predicted to enable glycine transmembrane transporter activity. Predicted to be involved in erythrocyte differentiation and glycine import into mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in cranial ganglion; dorsal root ganglion; liver lobe; and medulla oblongata basal plate. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 2. Orthologous to human SLC25A38 (solute carrier family 25 member 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 24.0), liver E14 (RPKM 21.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F4; 9 71.4 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119939428..119953570)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (120110377..120126093)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene C-X3-C motif chemokine receptor 1 Neighboring gene predicted gene, 33858 Neighboring gene C-C motif chemokine receptor 8 Neighboring gene STARR-seq mESC enhancer starr_25492 Neighboring gene STARR-positive B cell enhancer ABC_E3867 Neighboring gene STARR-positive B cell enhancer ABC_E2312 Neighboring gene STARR-positive B cell enhancer ABC_E1399 Neighboring gene predicted gene, 24044 Neighboring gene predicted gene, 26448 Neighboring gene ribosomal protein SA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of appoptosin promotes mitochondrial damage in MIN6 cells. Wang T, et al. Mol Med Rep, 2018 May. PMID 29568862, Free PMC Article
  2. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Zhao Y, et al. Neuron, 2015 Sep 2. PMID 26335643, Free PMC Article
  3. Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. Zhang H, et al. J Neurosci, 2012 Oct 31. PMID 23115192, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC18873

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine import into mitochondrion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitochondrial glycine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421436.1 → NP_001408365.1  mitochondrial glycine transporter isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110091

  2. NM_144793.2 → NP_659042.1  mitochondrial glycine transporter isoform 1

    See identical proteins and their annotated locations for NP_659042.1

    Status: VALIDATED

    Source sequence(s)
    AC110091, AK078385, BM115906, CJ159224
    Consensus CDS
    CCDS23622.1
    UniProtKB/Swiss-Prot
    Q91XD8
    Related
    ENSMUSP00000035106.6, ENSMUST00000035106.12
    Conserved Domains (2) summary
    PTZ00169
    Location:51 → 318
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:46 → 137
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119939428..119953570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154770.1 → XP_036010663.1  mitochondrial glycine transporter isoform X4

    Conserved Domains (1) summary
    pfam00153
    Location:89 → 176
    Mito_carr; Mitochondrial carrier protein

  2. XM_006512021.4 → XP_006512084.1  mitochondrial glycine transporter isoform X4

    See identical proteins and their annotated locations for XP_006512084.1

    Conserved Domains (1) summary
    pfam00153
    Location:89 → 176
    Mito_carr; Mitochondrial carrier protein

  3. XM_030244176.2 → XP_030100036.1  mitochondrial glycine transporter isoform X4

    Conserved Domains (1) summary
    pfam00153
    Location:89 → 176
    Mito_carr; Mitochondrial carrier protein

  4. XM_006512019.5 → XP_006512082.1  mitochondrial glycine transporter isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:24 → 115
    Mito_carr; Mitochondrial carrier protein

  5. XM_011242949.3 → XP_011241251.1  mitochondrial glycine transporter isoform X3

    See identical proteins and their annotated locations for XP_011241251.1

    Conserved Domains (1) summary
    pfam00153
    Location:30 → 113
    Mito_carr; Mitochondrial carrier protein

  6. XM_006512020.3 → XP_006512083.1  mitochondrial glycine transporter isoform X3

    See identical proteins and their annotated locations for XP_006512083.1

    Conserved Domains (1) summary
    pfam00153
    Location:30 → 113
    Mito_carr; Mitochondrial carrier protein

  7. XM_011242950.4 → XP_011241252.1  mitochondrial glycine transporter isoform X3

    See identical proteins and their annotated locations for XP_011241252.1

    Conserved Domains (1) summary
    pfam00153
    Location:30 → 113
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XD8.1 GenPept UniProtKB/Swiss-Prot:Q91XD8

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