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Alg3 ALG3 alpha-1,3- mannosyltransferase [ Mus musculus (house mouse) ]

Gene ID: 208624, updated on 11-Apr-2024

Summary

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Official Symbol
Alg3provided by MGI
Official Full Name
ALG3 alpha-1,3- mannosyltransferaseprovided by MGI
Primary source
MGI:MGI:1098592
See related
Ensembl:ENSMUSG00000033809 AllianceGenome:MGI:1098592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
not; D16Ertd36e
Summary
Predicted to enable dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and retina. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Id. Orthologous to human ALG3 (ALG3 alpha-1,3- mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 3.1), ovary adult (RPKM 2.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A3; 16 12.48 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20424208..20429515, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20605458..20610761, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35685 Neighboring gene von Willebrand factor A domain containing 5B2 Neighboring gene microRNA 1224 Neighboring gene STARR-positive B cell enhancer ABC_E10894 Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene Eef1akmt4-endothelin converting enzyme 2 readthrough Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy. Liu P, et al. Cell Mol Life Sci, 2022 Jun 8. PMID 35676564
  2. Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes. Pappano WN, et al. Genomics, 1998 Sep 1. PMID 9782094
  3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.
    Title: Inhibition of ALG3 stimulates cancer cell immunogenic ferroptosis to potentiate immunotherapy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36684

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-1,3-mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
Names
alpha-1,3-mannosyltransferase ALG3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)
asparagine-linked glycosylation protein 3 homolog
dol-P-Man-dependent alpha(1-3)-mannosyltransferase
dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase
dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
not56-like protein
NP_001344332.1
NP_001344333.1
NP_001344334.1
NP_001344335.1
NP_666051.2
XP_006521995.1
XP_030104881.1
XP_030104882.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357403.1 → NP_001344332.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087898
    Consensus CDS
    CCDS88898.1
    UniProtKB/TrEMBL
    A0A338P6Y8, A0A338P726
    Related
    ENSMUSP00000156241.2, ENSMUST00000231531.2
    Conserved Domains (1) summary
    pfam05208
    Location:1 → 284
    ALG3; ALG3 protein

  2. NM_001357404.1 → NP_001344333.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: Variants 3, 4, and 5 encode the same isoform (3).
    Source sequence(s)
    AC087898
    Conserved Domains (1) summary
    pfam05208
    Location:1 → 198
    ALG3; ALG3 protein

  3. NM_001357405.1 → NP_001344334.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: Variants 3, 4, and 5 encode the same isoform (3).
    Source sequence(s)
    AC087898
    Conserved Domains (1) summary
    pfam05208
    Location:1 → 198
    ALG3; ALG3 protein

  4. NM_001357406.1 → NP_001344335.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: Variants 3, 4, and 5 encode the same isoform (3).
    Source sequence(s)
    AC087898
    Conserved Domains (1) summary
    pfam05208
    Location:1 → 198
    ALG3; ALG3 protein

  5. NM_145939.3 → NP_666051.2  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform 1

    See identical proteins and their annotated locations for NP_666051.2

    Status: VALIDATED

    Source sequence(s)
    AC087898
    Consensus CDS
    CCDS37289.1
    UniProtKB/Swiss-Prot
    E9QKP9, Q8K2A8
    UniProtKB/TrEMBL
    A0A338P6Y8
    Related
    ENSMUSP00000045272.9, ENSMUST00000045918.15
    Conserved Domains (1) summary
    pfam05208
    Location:49 → 406
    ALG3; ALG3 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    20424208..20429515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521932.5 → XP_006521995.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A338P6Y8
    Related
    ENSMUSP00000156158.2, ENSMUST00000232458.2
    Conserved Domains (1) summary
    pfam05208
    Location:32 → 371
    ALG3; ALG3 protein

  2. XM_030249022.2 → XP_030104882.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X3

    Conserved Domains (1) summary
    pfam05208
    Location:44 → 247
    ALG3; ALG3 protein

  3. XM_030249021.1 → XP_030104881.1  dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A338P6Y8
    Conserved Domains (1) summary
    pfam05208
    Location:44 → 350
    ALG3; ALG3 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2A8.2 GenPept UniProtKB/Swiss-Prot:Q8K2A8

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