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Stat4 signal transducer and activator of transcription 4 [ Mus musculus (house mouse) ]

Gene ID: 20849, updated on 16-Apr-2024

Summary

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Official Symbol
Stat4provided by MGI
Official Full Name
signal transducer and activator of transcription 4provided by MGI
Primary source
MGI:MGI:103062
See related
Ensembl:ENSMUSG00000062939 AllianceGenome:MGI:103062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Biased expression in testis adult (RPKM 66.2) and spleen adult (RPKM 2.1) See more
Orthologs
human all
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Genomic context

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Location:
1 C1.1; 1 26.67 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52026265..52146348)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (51987106..52107189)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8419 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:52061000-52061301 Neighboring gene STARR-positive B cell enhancer ABC_E2542 Neighboring gene STARR-seq mESC enhancer starr_00894 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10010 Neighboring gene predicted gene, 31812 Neighboring gene STARR-positive B cell enhancer ABC_E3272 Neighboring gene STARR-positive B cell enhancer ABC_E3273 Neighboring gene signal transducer and activator of transcription 1 Neighboring gene transmembrane protein 209 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7722 Neighboring gene glutaminase Neighboring gene STARR-positive B cell enhancer ABC_E1992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Model of a Human STAT4 Point Mutation That Predisposes to Disseminated Coccidiomycosis. Powell DA, et al. Immunohorizons, 2022 Feb 11. PMID 35149520, Free PMC Article
  2. STAT4 is expressed in neutrophils and promotes antimicrobial immunity. Mehrpouya-Bahrami P, et al. JCI Insight, 2021 Jul 22. PMID 34138758, Free PMC Article
  3. Trichinella spiralis cystatin, TsCstN, modulates STAT4/IL-12 to specifically suppress IFN-γ production. Kobpornchai P, et al. Cell Immunol, 2021 Apr. PMID 33611078
  4. STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus-like Autoimmune- and Foreign Antigen-Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses. Fike AJ, et al. Immunohorizons, 2021 Jan 14. PMID 33446493
  5. Immune Suppression Mediated by STAT4 Deficiency Promotes Lymphatic Metastasis in HNSCC. Anderson K, et al. Front Immunol, 2019. PMID 32010142, Free PMC Article

See all (335) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway.
    Title: STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway.
  2. Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet.
    Title: Myeloid cell deficiency of the inflammatory transcription factor Stat4 protects long-term synaptic plasticity from the effects of a high-fat, high-cholesterol diet.
  3. Down-Regulation-Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-gamma Production.
    Title: Down-Regulation-Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-γ Production.
  4. UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancer.
    Title: UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancer.
  5. Mouse Model of a Human STAT4 Point Mutation That Predisposes to Disseminated Coccidiomycosis.
    Title: Mouse Model of a Human STAT4 Point Mutation That Predisposes to Disseminated Coccidiomycosis.
  6. Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
    Title: Occludin facilitates tumour angiogenesis in bladder cancer by regulating IL8/STAT3 through STAT4.
  7. STAT4 is expressed in neutrophils and promotes antimicrobial immunity.
    Title: STAT4 is expressed in neutrophils and promotes antimicrobial immunity.
  8. Silencing IL12p35 Promotes Angiotensin II-Mediated Abdominal Aortic Aneurysm through Activating the STAT4 Pathway.
    Title: Silencing IL12p35 Promotes Angiotensin II-Mediated Abdominal Aortic Aneurysm through Activating the STAT4 Pathway.
  9. STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus-like Autoimmune- and Foreign Antigen-Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses.
    Title: STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus-like Autoimmune- and Foreign Antigen-Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses.
  10. Trichinella spiralis cystatin, TsCstN, modulates STAT4/IL-12 to specifically suppress IFN-gamma production.
    Title: Trichinella spiralis cystatin, TsCstN, modulates STAT4/IL-12 to specifically suppress IFN-γ production.
Submit: New GeneRIF Correction See all GeneRIFs (99)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-helper 1 cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interleukin-12-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within leukocyte proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to interleukin-6 ISO
Inferred from Sequence Orthology
more info
  
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal transducer and activator of transcription 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308266.1 → NP_001295195.1  signal transducer and activator of transcription 4

    See identical proteins and their annotated locations for NP_001295195.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK132675, BF020635
    Consensus CDS
    CCDS14943.1
    UniProtKB/Swiss-Prot
    P42228
    UniProtKB/TrEMBL
    Q3V157
    Related
    ENSMUSP00000130713.2, ENSMUST00000168302.8
    Conserved Domains (4) summary
    cd10375
    Location:553 → 700
    SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140 → 314
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:316 → 562
    STAT_bind; STAT protein, DNA binding domain

  2. NM_011487.5 → NP_035617.1  signal transducer and activator of transcription 4

    See identical proteins and their annotated locations for NP_035617.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC108840, AK132675, BF020635, BY097735, BY750146
    Consensus CDS
    CCDS14943.1
    UniProtKB/Swiss-Prot
    P42228
    UniProtKB/TrEMBL
    Q3V157
    Related
    ENSMUSP00000027277.6, ENSMUST00000027277.7
    Conserved Domains (4) summary
    cd10375
    Location:553 → 700
    SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
    smart00964
    Location:2 → 121
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:140 → 314
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:316 → 562
    STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    52026265..52146348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495815.2 → XP_006495878.1  signal transducer and activator of transcription 4 isoform X1

    UniProtKB/Swiss-Prot
    P42228
    Conserved Domains (4) summary
    cd10375
    Location:573 → 720
    SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
    cd16854
    Location:160 → 332
    STAT4_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 4 (STAT4)
    cd16848
    Location:336 → 493
    STAT4_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 4 (STAT4)
    cl03749
    Location:64 → 141
    STAT_int; STAT protein, protein interaction domain

  2. XM_006495816.1 → XP_006495879.1  signal transducer and activator of transcription 4 isoform X2

    UniProtKB/Swiss-Prot
    P42228
    Conserved Domains (4) summary
    cd10375
    Location:502 → 649
    SH2_STAT4; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 4proteins
    cd16854
    Location:89 → 261
    STAT4_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 4 (STAT4)
    cd16848
    Location:265 → 422
    STAT4_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 4 (STAT4)
    cl03749
    Location:14 → 70
    STAT_int; STAT protein, protein interaction domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42228.1 GenPept UniProtKB/Swiss-Prot:P42228

Gene LinkOut

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