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Stag2 STAG2 cohesin complex component [ Mus musculus (house mouse) ]

Gene ID: 20843, updated on 9-Dec-2024

Summary

Official Symbol
Stag2provided by MGI
Official Full Name
STAG2 cohesin complex componentprovided by MGI
Primary source
MGI:MGI:1098583
See related
Ensembl:ENSMUSG00000025862 AllianceGenome:MGI:1098583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SA-2; SAP2; 9230105L23Rik; B230112I07Rik
Summary
Enables chromatin binding activity. Acts upstream of or within stem cell population maintenance. Located in chromatin. Is expressed in several structures, including genitourinary system; integumental system; limb; liver; and nervous system. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked and Mullegama-Klein-Martinez syndrome. Orthologous to human STAG2 (STAG2 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.4), liver E14 (RPKM 10.4) and 24 other tissues See more
Orthologs
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Genomic context

See Stag2 in Genome Data Viewer
Location:
X A4; X 23.19 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (41238172..41366063)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (42149297..42277186)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47060 Neighboring gene X-linked inhibitor of apoptosis Neighboring gene STARR-positive B cell enhancer ABC_E9459 Neighboring gene zinc finger protein 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47063 Neighboring gene RIKEN cDNA B230118I11 gene Neighboring gene predicted gene, 54068 Neighboring gene STARR-seq mESC enhancer starr_47064

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding  
enables chromatin binding PubMed 
Process Evidence Code Pubs
involved_in cell division  
involved_in chromosome segregation  
involved_in meiotic cell cycle  
involved_in mitotic spindle assembly  
involved_in sister chromatid cohesion  
involved_in sister chromatid cohesion  
involved_in sister chromatid cohesion  
acts_upstream_of_or_within stem cell population maintenance PubMed 
Component Evidence Code Pubs
located_in chromatin  
located_in chromatin PubMed 
located_in chromatin  
located_in chromosome, centromeric region  
part_of cohesin complex  
part_of cohesin complex  
part_of cohesin complex  
located_in fibrillar center  
part_of mitotic cohesin complex  
located_in mitotic spindle pole  
located_in nuclear matrix  
located_in nucleolus  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  

General protein information

Preferred Names
cohesin subunit SA-2
Names
SCC3 homolog 2
nuclear protein SA2
stromal antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077712.2NP_001071180.1  cohesin subunit SA-2 isoform 1

    See identical proteins and their annotated locations for NP_001071180.1

    Status: VALIDATED

    Source sequence(s)
    AA461826, AK161072, AL672089, BC066041, CN669441, CO434048
    Consensus CDS
    CCDS40952.1
    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Related
    ENSMUSP00000110724.2, ENSMUST00000115072.8
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  2. NM_001290713.2NP_001277642.1  cohesin subunit SA-2 isoform 2

    See identical proteins and their annotated locations for NP_001277642.1

    Status: VALIDATED

    Source sequence(s)
    AA461826, AK161072, AL672089, BC066041, CN708963, CO434048
    Consensus CDS
    CCDS72371.1
    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  3. NM_001358225.1NP_001345154.1  cohesin subunit SA-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA461826, AL672089
    Consensus CDS
    CCDS40952.1
    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  4. NM_021465.4NP_067440.3  cohesin subunit SA-2 isoform 1

    See identical proteins and their annotated locations for NP_067440.3

    Status: VALIDATED

    Source sequence(s)
    AA461826, AK146718, AK161072, BC066041, CO434048
    Consensus CDS
    CCDS40952.1
    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Related
    ENSMUSP00000063250.8, ENSMUST00000069619.14
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    41238172..41366063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251277.2XP_030107137.1  cohesin subunit SA-2 isoform X1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  2. XM_011250984.4XP_011249286.1  cohesin subunit SA-2 isoform X1

    See identical proteins and their annotated locations for XP_011249286.1

    UniProtKB/TrEMBL
    A2AFF6
    Related
    ENSMUSP00000110725.3, ENSMUST00000115073.9
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  3. XM_036161875.1XP_036017768.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  4. XM_011250987.2XP_011249289.1  cohesin subunit SA-2 isoform X1

    See identical proteins and their annotated locations for XP_011249289.1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  5. XM_036161873.1XP_036017766.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  6. XM_030251276.2XP_030107136.1  cohesin subunit SA-2 isoform X1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  7. XM_036161872.1XP_036017765.1  cohesin subunit SA-2 isoform X1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  8. XM_036161878.1XP_036017771.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  9. XM_011250989.4XP_011249291.1  cohesin subunit SA-2 isoform X2

    See identical proteins and their annotated locations for XP_011249291.1

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  10. XM_036161876.1XP_036017769.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  11. XM_011250985.4XP_011249287.1  cohesin subunit SA-2 isoform X1

    See identical proteins and their annotated locations for XP_011249287.1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  12. XM_036161874.1XP_036017767.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  13. XM_011250988.3XP_011249290.1  cohesin subunit SA-2 isoform X1

    See identical proteins and their annotated locations for XP_011249290.1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
  14. XM_036161877.1XP_036017770.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157265
    STAG; STAG domain
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