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Stag2 STAG2 cohesin complex component [ Mus musculus (house mouse) ]

Gene ID: 20843, updated on 21-Apr-2024

Summary

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Official Symbol
Stag2provided by MGI
Official Full Name
STAG2 cohesin complex componentprovided by MGI
Primary source
MGI:MGI:1098583
See related
Ensembl:ENSMUSG00000025862 AllianceGenome:MGI:1098583
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SA-2; SAP2; 9230105L23Rik; B230112I07Rik
Summary
Enables chromatin binding activity. Acts upstream of or within stem cell population maintenance. Located in chromatin. Is expressed in genitourinary system; integumental system; limb; nervous system; and tail. Human ortholog(s) of this gene implicated in Mullegama-Klein-Martinez syndrome and holoprosencephaly. Orthologous to human STAG2 (stromal antigen 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.4), liver E14 (RPKM 10.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A4; X 23.19 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (41238172..41366063)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (42149297..42277186)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47060 Neighboring gene X-linked inhibitor of apoptosis Neighboring gene STARR-positive B cell enhancer ABC_E9459 Neighboring gene zinc finger protein 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47063 Neighboring gene RIKEN cDNA B230118I11 gene Neighboring gene predicted gene, 54068 Neighboring gene STARR-seq mESC enhancer starr_47064

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STAG2 promotes the myelination transcriptional program in oligodendrocytes. Cheng N, et al. Elife, 2022 Aug 12. PMID 35959892, Free PMC Article
  2. [Molecular pathogenesis of myelodysplastic syndromes with concurrent mutations in cohesin STAG2 and transcription factor RUNX1]. Ochi Y. Rinsho Ketsueki, 2021. PMID 34108313
  3. Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells. Arruda NL, et al. Epigenetics Chromatin, 2020 Aug 10. PMID 32778134, Free PMC Article
  4. Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Ochi Y, et al. Cancer Discov, 2020 Jun. PMID 32249213, Free PMC Article
  5. Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. Remeseiro S, et al. EMBO J, 2012 May 2. PMID 22415365, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells.
    Title: STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells.
  2. STAG2 promotes the myelination transcriptional program in oligodendrocytes.
    Title: STAG2 promotes the myelination transcriptional program in oligodendrocytes.
  3. [Molecular pathogenesis of myelodysplastic syndromes with concurrent mutations in cohesin STAG2 and transcription factor RUNX1].
    Title: [Molecular pathogenesis of myelodysplastic syndromes with concurrent mutations in cohesin STAG2 and transcription factor RUNX1].
  4. Essential Roles of Cohesin STAG2 in Mouse Embryonic Development and Adult Tissue Homeostasis.
    Title: Essential Roles of Cohesin STAG2 in Mouse Embryonic Development and Adult Tissue Homeostasis.
  5. Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells.
    Title: Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells.
  6. we show that loss of Stag2 cooperates with EWS-FLI1 and p53 mutation to promote sarcomagenesis in murine MSCs
    Title: Loss of Stag2 cooperates with EWS-FLI1 to transform murine Mesenchymal stem cells.
  7. a cohesin complex containing Rad21 and STAG2 cooperates with a STAG3-specific complex to maintain sister chromatid cohesion during the diplotene stage of meiosis
    Title: STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cohesin complex ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
part_of mitotic cohesin complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cohesin subunit SA-2
Names
SCC3 homolog 2
nuclear protein SA2
stromal antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077712.2 → NP_001071180.1  cohesin subunit SA-2 isoform 1

    See identical proteins and their annotated locations for NP_001071180.1

    Status: VALIDATED

    Source sequence(s)
    AA461826, AK161072, AL672089, BC066041, CN669441, CO434048
    Consensus CDS
    CCDS40952.1
    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Related
    ENSMUSP00000110724.2, ENSMUST00000115072.8
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  2. NM_001290713.2 → NP_001277642.1  cohesin subunit SA-2 isoform 2

    See identical proteins and their annotated locations for NP_001277642.1

    Status: VALIDATED

    Source sequence(s)
    AA461826, AK161072, AL672089, BC066041, CN708963, CO434048
    Consensus CDS
    CCDS72371.1
    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  3. NM_001358225.1 → NP_001345154.1  cohesin subunit SA-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA461826, AL672089
    Consensus CDS
    CCDS40952.1
    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  4. NM_021465.4 → NP_067440.3  cohesin subunit SA-2 isoform 1

    See identical proteins and their annotated locations for NP_067440.3

    Status: VALIDATED

    Source sequence(s)
    AA461826, AK146718, AK161072, BC066041, CO434048
    Consensus CDS
    CCDS40952.1
    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Related
    ENSMUSP00000063250.8, ENSMUST00000069619.14
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    41238172..41366063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251277.2 → XP_030107137.1  cohesin subunit SA-2 isoform X1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  2. XM_011250984.4 → XP_011249286.1  cohesin subunit SA-2 isoform X1

    See identical proteins and their annotated locations for XP_011249286.1

    UniProtKB/TrEMBL
    A2AFF6
    Related
    ENSMUSP00000110725.3, ENSMUST00000115073.9
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  3. XM_036161875.1 → XP_036017768.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  4. XM_011250987.2 → XP_011249289.1  cohesin subunit SA-2 isoform X1

    See identical proteins and their annotated locations for XP_011249289.1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  5. XM_036161873.1 → XP_036017766.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  6. XM_030251276.2 → XP_030107136.1  cohesin subunit SA-2 isoform X1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  7. XM_036161872.1 → XP_036017765.1  cohesin subunit SA-2 isoform X1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  8. XM_036161878.1 → XP_036017771.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  9. XM_011250989.4 → XP_011249291.1  cohesin subunit SA-2 isoform X2

    See identical proteins and their annotated locations for XP_011249291.1

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  10. XM_036161876.1 → XP_036017769.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  11. XM_011250985.4 → XP_011249287.1  cohesin subunit SA-2 isoform X1

    See identical proteins and their annotated locations for XP_011249287.1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  12. XM_036161874.1 → XP_036017767.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  13. XM_011250988.3 → XP_011249290.1  cohesin subunit SA-2 isoform X1

    See identical proteins and their annotated locations for XP_011249290.1

    UniProtKB/TrEMBL
    A2AFF6
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain

  14. XM_036161877.1 → XP_036017770.1  cohesin subunit SA-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AFF5, O35638, Q6NZN7
    Conserved Domains (1) summary
    pfam08514
    Location:157 → 265
    STAG; STAG domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35638.3 GenPept UniProtKB/Swiss-Prot:O35638

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