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Ssrp1 structure specific recognition protein 1 [ Mus musculus (house mouse) ]

Gene ID: 20833, updated on 21-Apr-2024

Summary

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Official Symbol
Ssrp1provided by MGI
Official Full Name
structure specific recognition protein 1provided by MGI
Primary source
MGI:MGI:107912
See related
Ensembl:ENSMUSG00000027067 AllianceGenome:MGI:107912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T160; Hmgox; Hmg1-rs1; Hmgi-rs3
Summary
Enables chromatin binding activity. Predicted to be involved in regulation of chromatin organization. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be located in chromosome and nucleus. Predicted to be part of FACT complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 88.2), liver E14 (RPKM 67.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 D; 2 49.45 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84867519..84877453)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (85037120..85047114)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39868 Neighboring gene proteoglycan 3 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 3 Neighboring gene STARR-positive B cell enhancer ABC_E225 Neighboring gene tankyrase 1 binding protein 1 Neighboring gene RIKEN cDNA 4930443O20 gene Neighboring gene STARR-seq mESC enhancer starr_05013

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos. Cao S, et al. Mol Cell Biol, 2003 Aug. PMID 12861016, Free PMC Article
  2. The high-mobility group protein T160 binds to both linear and cruciform DNA and mediates DNA bending as determined by ring closure. Gariglio M, et al. Exp Cell Res, 1997 Nov 1. PMID 9367632
  3. Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters. Chen F, et al. Nucleic Acids Res, 2020 Oct 9. PMID 32894293, Free PMC Article
  4. Prevention of Chromatin Destabilization by FACT Is Crucial for Malignant Transformation. Sandlesh P, et al. iScience, 2020 Jun 26. PMID 32498018, Free PMC Article
  5. Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene. Sandlesh P, et al. PLoS One, 2018. PMID 29953487, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1.
    Title: Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1.
  2. Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.
    Title: Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters.
  3. It has been demonstrated that FACT potentiates H2A.X-dependent signaling of DNA damage.
    Title: The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage.
  4. Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene.
    Title: Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene.
  5. FACT is required for TOP1 binding to H3K4me3 at non-B DNA containing chromatin for the site-specific cleavage.
    Title: Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability.
  6. Ssrp1 appears to encode nonredundant and p53-independent functions that are essential for cell viability
    Title: The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of FACT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of FACT complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FACT complex subunit SSRP1
Names
facilitates chromatin transcription complex subunit SSRP1
recombination signal sequence recognition protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136081.3 → NP_001129553.1  FACT complex subunit SSRP1

    See identical proteins and their annotated locations for NP_001129553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon structure and differs in the 5' UTR compared to variant 4. All five variants encode the same protein.
    Source sequence(s)
    AL935159, BX546441
    Consensus CDS
    CCDS38165.1
    UniProtKB/Swiss-Prot
    Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
    UniProtKB/TrEMBL
    A2AW05
    Related
    ENSMUSP00000127058.2, ENSMUST00000168266.8
    Conserved Domains (2) summary
    COG5165
    Location:21 → 480
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    pfam00505
    Location:547 → 614
    HMG_box; HMG (high mobility group) box

  2. NM_001421071.1 → NP_001408000.1  FACT complex subunit SSRP1

    Status: VALIDATED

    Source sequence(s)
    AL935159, BX546441
    UniProtKB/Swiss-Prot
    Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6

  3. NM_001421072.1 → NP_001408001.1  FACT complex subunit SSRP1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AL935159, BX546441
    UniProtKB/Swiss-Prot
    Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6

  4. NM_001421073.1 → NP_001408002.1  FACT complex subunit SSRP1

    Status: VALIDATED

    Source sequence(s)
    AL935159, BX546441
    UniProtKB/Swiss-Prot
    Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6

  5. NM_182990.5 → NP_892035.2  FACT complex subunit SSRP1

    See identical proteins and their annotated locations for NP_892035.2

    Status: VALIDATED

    Source sequence(s)
    AL935159, BX546441
    Consensus CDS
    CCDS38165.1
    UniProtKB/Swiss-Prot
    Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6
    UniProtKB/TrEMBL
    A2AW05
    Related
    ENSMUSP00000076971.7, ENSMUST00000077798.13
    Conserved Domains (2) summary
    COG5165
    Location:21 → 480
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    pfam00505
    Location:547 → 614
    HMG_box; HMG (high mobility group) box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84867519..84877453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239405.2 → XP_011237707.1  FACT complex subunit SSRP1 isoform X2

    Conserved Domains (1) summary
    COG5165
    Location:21 → 436
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08943.2 GenPept UniProtKB/Swiss-Prot:Q08943

Gene LinkOut

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