Tmprss7 transmembrane serine protease 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmprss7provided by MGI
Official Full Name: transmembrane serine protease 7provided by MGI
Primary source: MGI:MGI:2686594
See related: Ensembl:ENSMUSG00000033177 AllianceGenome:MGI:2686594
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1748; B230219I23Rik
Summary: Enables serine-type peptidase activity. Involved in proteolysis. Located in plasma membrane. Orthologous to human TMPRSS7 (transmembrane serine protease 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 29.84 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (45476672..45521822, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (45656309..45698553, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16Mit138 (e-PCR), detects polymorphism
- UniSTS:127769

D16Mit138.1 (e-PCR), detects polymorphism
- UniSTS:127770

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transmembrane protease serine 7

Names: matriptase-3; transmembrane protease, serine 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172455.3 → NP_766043.3 transmembrane protease serine 7

See identical proteins and their annotated locations for NP_766043.3

Status: VALIDATED

Source sequence(s)

AC166572, AK045663, DQ061860

Consensus CDS

CCDS37347.2

UniProtKB/Swiss-Prot

E9QME7, Q4PPC3, Q8BIK6

Related

ENSMUSP00000110209.3, ENSMUST00000114562.3

Conserved Domains (4) summary

smart00020
Location:591 → 821

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:257 → 345

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:470 → 504

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01390
Location:94 → 194

SEA; SEA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

45476672..45521822 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521917.3 → XP_006521980.1 transmembrane protease serine 7 isoform X5

Conserved Domains (4) summary

smart00020
Location:554 → 784

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:257 → 345

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:470 → 504

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01390
Location:94 → 194

SEA; SEA domain
XM_006521915.4 → XP_006521978.1 transmembrane protease serine 7 isoform X1

See identical proteins and their annotated locations for XP_006521978.1

UniProtKB/Swiss-Prot

E9QME7, Q4PPC3, Q8BIK6

Conserved Domains (4) summary

smart00020
Location:591 → 821

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:257 → 345

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:470 → 504

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01390
Location:94 → 194

SEA; SEA domain
XM_006521914.4 → XP_006521977.1 transmembrane protease serine 7 isoform X1

See identical proteins and their annotated locations for XP_006521977.1

UniProtKB/Swiss-Prot

E9QME7, Q4PPC3, Q8BIK6

Conserved Domains (4) summary

smart00020
Location:591 → 821

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:257 → 345

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:470 → 504

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01390
Location:94 → 194

SEA; SEA domain
XM_017316908.2 → XP_017172397.1 transmembrane protease serine 7 isoform X4

Conserved Domains (4) summary

smart00020
Location:577 → 807

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:243 → 331

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:456 → 490

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01390
Location:94 → 193

SEA; SEA domain
XM_006521916.3 → XP_006521979.1 transmembrane protease serine 7 isoform X2

Conserved Domains (4) summary

smart00020
Location:590 → 820

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:256 → 344

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:469 → 503

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01390
Location:94 → 193

SEA; SEA domain
XM_017316907.2 → XP_017172396.1 transmembrane protease serine 7 isoform X3

Conserved Domains (4) summary

smart00020
Location:578 → 808

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:244 → 332

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:457 → 491

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01390
Location:94 → 194

SEA; SEA domain
XM_017316909.2 → XP_017172398.1 transmembrane protease serine 7 isoform X7

Conserved Domains (3) summary

smart00020
Location:334 → 564

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:2 → 88

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:213 → 247

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_017316911.1 → XP_017172400.1 transmembrane protease serine 7 isoform X8

Related

ENSMUST00000169421.9

Conserved Domains (2) summary

smart00020
Location:222 → 452

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:101 → 135

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_036159836.1 → XP_036015729.1 transmembrane protease serine 7 isoform X6

Related

ENSMUST00000170951.8

Conserved Domains (4) summary

smart00020
Location:529 → 759

Tryp_SPc; Trypsin-like serine protease

cd00041
Location:195 → 283

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00112
Location:408 → 442

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01390
Location:68 → 136

SEA; SEA domain
XM_017316910.2 → XP_017172399.1 transmembrane protease serine 7 isoform X8

Conserved Domains (2) summary

smart00020
Location:222 → 452

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:101 → 135

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...