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Srpk2 serine/arginine-rich protein specific kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 20817, updated on 3-Apr-2024

Summary

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Official Symbol
Srpk2provided by MGI
Official Full Name
serine/arginine-rich protein specific kinase 2provided by MGI
Primary source
MGI:MGI:1201408
See related
Ensembl:ENSMUSG00000062604 AllianceGenome:MGI:1201408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wbp6; mSRPK2
Summary
Enables several functions, including 14-3-3 protein binding activity; ATP binding activity; and magnesium ion binding activity. Involved in several processes, including nuclear speck organization; positive regulation of neuron apoptotic process; and spliceosomal complex assembly. Located in cytoplasm and nucleus. Is expressed in central nervous system; neural retina; and olfactory epithelium. Orthologous to human SRPK2 (SRSF protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 17.3), frontal lobe adult (RPKM 13.0) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A3; 5 10.36 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (23708262..23889639, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (23503356..23684642, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene SPATA31 subfamily H member 2 Neighboring gene STARR-seq mESC enhancer starr_12600 Neighboring gene STARR-seq mESC enhancer starr_12601 Neighboring gene STARR-seq mESC enhancer starr_12603 Neighboring gene RIKEN cDNA 5031425E22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:22892703-22893070 Neighboring gene STARR-seq mESC enhancer starr_12606 Neighboring gene STARR-seq mESC enhancer starr_12607 Neighboring gene STARR-positive B cell enhancer ABC_E528 Neighboring gene STARR-positive B cell enhancer ABC_E1297 Neighboring gene lysine (K)-specific methyltransferase 2E Neighboring gene STARR-seq mESC enhancer starr_12611 Neighboring gene STARR-positive B cell enhancer mm9_chr5:23122338-23122639 Neighboring gene STARR-positive B cell enhancer mm9_chr5:23143262-23143562 Neighboring gene STARR-seq mESC enhancer starr_12614 Neighboring gene STARR-positive B cell enhancer mm9_chr5:23206519-23206819 Neighboring gene expressed sequence AI506816 Neighboring gene predicted gene, 42226 Neighboring gene predicted gene, 50451

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Wong JC, et al. Blood, 2010 Jun 3. PMID 20233966, Free PMC Article
  2. Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. Nowak DG, et al. J Biol Chem, 2010 Feb 19. PMID 19906640, Free PMC Article
  3. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). Koizumi J, et al. J Biol Chem, 1999 Apr 16. PMID 10196197
  4. Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Kuroyanagi N, et al. Biochem Biophys Res Commun, 1998 Jan 14. PMID 9446799
  5. SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease. Hong Y, et al. J Neurosci, 2012 Nov 28. PMID 23197718, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRPK2 may contribute to the formation of hyperphosphorylated tau and the pathogenesis of Alzheimer disease.
    Title: SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.
  2. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
    Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in R-loop processing ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear speck organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spliceosomal complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SRSF protein kinase 2
Names
SFRS protein kinase 2
SR-protein-specific kinase 2
WW domain binding protein 6
serine/threonine-protein kinase SRPK2
NP_001346101.1
NP_001346102.1
NP_001346103.1
NP_001346104.1
NP_001394425.1
NP_001394427.1
NP_001394428.1
NP_001394429.1
NP_001394430.1
NP_001394431.1
NP_001394432.1
NP_001394433.1
NP_001394434.1
NP_001394435.1
NP_001394436.1
NP_001394437.1
NP_001394438.1
NP_001394439.1
NP_001394440.1
NP_001394441.1
NP_001394442.1
NP_001394443.1
NP_001394444.1
NP_001394445.1
NP_001394446.1
NP_001394447.1
NP_001394448.1
NP_001394449.1
NP_001394450.1
NP_001394451.1
NP_001394452.1
NP_033300.2
XP_011248053.1
XP_011248054.1
XP_011248056.1
XP_011248057.1
XP_011248058.1
XP_011248059.1
XP_011248061.1
XP_017176257.1
XP_017176259.1
XP_017176261.1
XP_030110172.1
XP_030110173.1
XP_030110174.1
XP_030110175.1
XP_030110176.1
XP_030110177.1
XP_030110178.1
XP_030110179.1
XP_030110182.1
XP_030110184.1
XP_030110185.1
XP_036020848.1
XP_036020849.1
XP_036020850.1
XP_036020851.1
XP_036020853.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359172.2 → NP_001346101.1  SRSF protein kinase 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC117614, AC122022
    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    cl21453
    Location:77 → 265
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:312 → 392
    Na_Ca_ex; Sodium/calcium exchanger protein

  2. NM_001359173.2 → NP_001346102.1  SRSF protein kinase 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022
    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    cl21453
    Location:77 → 265
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:312 → 392
    Na_Ca_ex; Sodium/calcium exchanger protein

  3. NM_001359174.2 → NP_001346103.1  SRSF protein kinase 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform c.
    Source sequence(s)
    AC117614, AC122022
    Consensus CDS
    CCDS39024.1
    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    UniProtKB/TrEMBL
    A0A0R4J124
    Conserved Domains (3) summary
    cd14217
    Location:66 → 254
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:500 → 680
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:301 → 381
    Na_Ca_ex; Sodium/calcium exchanger protein

  4. NM_001359175.2 → NP_001346104.1  SRSF protein kinase 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022
    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:292 → 372
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:491 → 671
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001407496.1 → NP_001394425.1  SRSF protein kinase 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  6. NM_001407498.1 → NP_001394427.1  SRSF protein kinase 2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  7. NM_001407499.1 → NP_001394428.1  SRSF protein kinase 2 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  8. NM_001407500.1 → NP_001394429.1  SRSF protein kinase 2 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  9. NM_001407501.1 → NP_001394430.1  SRSF protein kinase 2 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  10. NM_001407502.1 → NP_001394431.1  SRSF protein kinase 2 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  11. NM_001407503.1 → NP_001394432.1  SRSF protein kinase 2 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  12. NM_001407504.1 → NP_001394433.1  SRSF protein kinase 2 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  13. NM_001407505.1 → NP_001394434.1  SRSF protein kinase 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022
    UniProtKB/TrEMBL
    A0A0R4J124

  14. NM_001407506.1 → NP_001394435.1  SRSF protein kinase 2 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  15. NM_001407507.1 → NP_001394436.1  SRSF protein kinase 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  16. NM_001407508.1 → NP_001394437.1  SRSF protein kinase 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  17. NM_001407509.1 → NP_001394438.1  SRSF protein kinase 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  18. NM_001407510.1 → NP_001394439.1  SRSF protein kinase 2 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  19. NM_001407511.1 → NP_001394440.1  SRSF protein kinase 2 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  20. NM_001407512.1 → NP_001394441.1  SRSF protein kinase 2 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  21. NM_001407513.1 → NP_001394442.1  SRSF protein kinase 2 isoform q

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  22. NM_001407514.1 → NP_001394443.1  SRSF protein kinase 2 isoform r

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  23. NM_001407515.1 → NP_001394444.1  SRSF protein kinase 2 isoform s

    Status: VALIDATED

    Source sequence(s)
    AC122022

  24. NM_001407516.1 → NP_001394445.1  SRSF protein kinase 2 isoform t

    Status: VALIDATED

    Source sequence(s)
    AC122022

  25. NM_001407517.1 → NP_001394446.1  SRSF protein kinase 2 isoform u

    Status: VALIDATED

    Source sequence(s)
    AC122022

  26. NM_001407518.1 → NP_001394447.1  SRSF protein kinase 2 isoform v

    Status: VALIDATED

    Source sequence(s)
    AC122022

  27. NM_001407519.1 → NP_001394448.1  SRSF protein kinase 2 isoform w

    Status: VALIDATED

    Source sequence(s)
    AC122022

  28. NM_001407520.1 → NP_001394449.1  SRSF protein kinase 2 isoform w

    Status: VALIDATED

    Source sequence(s)
    AC122022

  29. NM_001407521.1 → NP_001394450.1  SRSF protein kinase 2 isoform x

    Status: VALIDATED

    Source sequence(s)
    AC122022

  30. NM_001407522.1 → NP_001394451.1  SRSF protein kinase 2 isoform x

    Status: VALIDATED

    Source sequence(s)
    AC122022

  31. NM_001407523.1 → NP_001394452.1  SRSF protein kinase 2 isoform y

    Status: VALIDATED

    Source sequence(s)
    AC122022
    UniProtKB/TrEMBL
    Q8C9R8

  32. NM_009274.3 → NP_033300.2  SRSF protein kinase 2 isoform c

    See identical proteins and their annotated locations for NP_033300.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform c.
    Source sequence(s)
    AC117614, AC122022
    Consensus CDS
    CCDS39024.1
    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    UniProtKB/TrEMBL
    A0A0R4J124
    Related
    ENSMUSP00000085734.5, ENSMUST00000088392.9
    Conserved Domains (3) summary
    cd14217
    Location:66 → 254
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    cl21453
    Location:500 → 680
    PKc_like; Protein Kinases, catalytic domain
    cl27511
    Location:301 → 381
    Na_Ca_ex; Sodium/calcium exchanger protein

RNA

  1. NR_152854.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  2. NR_176373.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  3. NR_176374.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  4. NR_176375.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  5. NR_176376.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  6. NR_176377.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  7. NR_176378.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  8. NR_176379.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117614, AC122022

  9. NR_176380.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122022

  10. NR_176381.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122022

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    23708262..23889639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249751.4 → XP_011248053.1  SRSF protein kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (3) summary
    cd14217
    Location:103 → 291
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    TIGR00927
    Location:338 → 418
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:537 → 748
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011249759.4 → XP_011248061.1  SRSF protein kinase 2 isoform X20

    Conserved Domains (2) summary
    TIGR00927
    Location:140 → 220
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:339 → 550
    PKc_like; Protein Kinases, catalytic domain

  3. XM_011249757.4 → XP_011248059.1  SRSF protein kinase 2 isoform X6

    See identical proteins and their annotated locations for XP_011248059.1

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:301 → 381
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 254
    PKc_like; Protein Kinases, catalytic domain

  4. XM_030254317.2 → XP_030110177.1  SRSF protein kinase 2 isoform X6

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:301 → 381
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 254
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030254314.2 → XP_030110174.1  SRSF protein kinase 2 isoform X6

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:301 → 381
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 254
    PKc_like; Protein Kinases, catalytic domain

  6. XM_030254315.2 → XP_030110175.1  SRSF protein kinase 2 isoform X6

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:301 → 381
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 254
    PKc_like; Protein Kinases, catalytic domain

  7. XM_030254316.2 → XP_030110176.1  SRSF protein kinase 2 isoform X6

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:301 → 381
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 254
    PKc_like; Protein Kinases, catalytic domain

  8. XM_017320770.3 → XP_017176259.1  SRSF protein kinase 2 isoform X13

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:203 → 283
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:402 → 613
    PKc_like; Protein Kinases, catalytic domain

  9. XM_030254324.2 → XP_030110184.1  SRSF protein kinase 2 isoform X13

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:203 → 283
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:402 → 613
    PKc_like; Protein Kinases, catalytic domain

  10. XM_030254322.2 → XP_030110182.1  SRSF protein kinase 2 isoform X13

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:203 → 283
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:402 → 613
    PKc_like; Protein Kinases, catalytic domain

  11. XM_011249756.3 → XP_011248058.1  SRSF protein kinase 2 isoform X6

    See identical proteins and their annotated locations for XP_011248058.1

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:301 → 381
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 254
    PKc_like; Protein Kinases, catalytic domain

  12. XM_011249755.4 → XP_011248057.1  SRSF protein kinase 2 isoform X6

    See identical proteins and their annotated locations for XP_011248057.1

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:301 → 381
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 254
    PKc_like; Protein Kinases, catalytic domain

  13. XM_030254313.2 → XP_030110173.1  SRSF protein kinase 2 isoform X6

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:301 → 381
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 254
    PKc_like; Protein Kinases, catalytic domain

  14. XM_036164955.1 → XP_036020848.1  SRSF protein kinase 2 isoform X6

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:301 → 381
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 254
    PKc_like; Protein Kinases, catalytic domain

  15. XM_030254318.2 → XP_030110178.1  SRSF protein kinase 2 isoform X6

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:301 → 381
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 254
    PKc_like; Protein Kinases, catalytic domain

  16. XM_036164957.1 → XP_036020850.1  SRSF protein kinase 2 isoform X9

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:292 → 372
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 245
    PKc_like; Protein Kinases, catalytic domain

  17. XM_036164958.1 → XP_036020851.1  SRSF protein kinase 2 isoform X9

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:292 → 372
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 245
    PKc_like; Protein Kinases, catalytic domain

  18. XM_017320768.2 → XP_017176257.1  SRSF protein kinase 2 isoform X8

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:329 → 409
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:103 → 282
    PKc_like; Protein Kinases, catalytic domain

  19. XM_011249752.3 → XP_011248054.1  SRSF protein kinase 2 isoform X2

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:329 → 409
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:103 → 282
    PKc_like; Protein Kinases, catalytic domain

  20. XM_011249754.3 → XP_011248056.1  SRSF protein kinase 2 isoform X4

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (3) summary
    cd14217
    Location:103 → 291
    STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
    TIGR00927
    Location:338 → 418
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:537 → 717
    PKc_like; Protein Kinases, catalytic domain

  21. XM_030254312.1 → XP_030110172.1  SRSF protein kinase 2 isoform X5

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:303 → 383
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:77 → 256
    PKc_like; Protein Kinases, catalytic domain

  22. XM_030254319.2 → XP_030110179.1  SRSF protein kinase 2 isoform X9

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:292 → 372
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 245
    PKc_like; Protein Kinases, catalytic domain

  23. XM_030254325.1 → XP_030110185.1  SRSF protein kinase 2 isoform X14

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:194 → 274
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:393 → 604
    PKc_like; Protein Kinases, catalytic domain

  24. XM_036164956.1 → XP_036020849.1  SRSF protein kinase 2 isoform X9

    UniProtKB/Swiss-Prot
    O54781, Q8VCD9
    Conserved Domains (2) summary
    TIGR00927
    Location:292 → 372
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:66 → 245
    PKc_like; Protein Kinases, catalytic domain

  25. XM_036164960.1 → XP_036020853.1  SRSF protein kinase 2 isoform X21

    Conserved Domains (2) summary
    TIGR00927
    Location:131 → 211
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:330 → 541
    PKc_like; Protein Kinases, catalytic domain

  26. XM_017320772.3 → XP_017176261.1  SRSF protein kinase 2 isoform X19

    Conserved Domains (2) summary
    TIGR00927
    Location:145 → 225
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl21453
    Location:344 → 555
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54781.2 GenPept UniProtKB/Swiss-Prot:O54781

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