Btla B and T lymphocyte associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Btlaprovided by MGI
Official Full Name: B and T lymphocyte associatedprovided by MGI
Primary source: MGI:MGI:2658978
See related: Ensembl:ENSMUSG00000052013 AllianceGenome:MGI:2658978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A630002H24
Summary: Enables signaling receptor activity. Acts upstream of or within immune response-regulating cell surface receptor signaling pathway; negative regulation of B cell proliferation; and negative regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is integral component of plasma membrane. Orthologous to human BTLA (B and T lymphocyte associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 9.3), mammary gland adult (RPKM 3.5) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 29.52 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (45043121..45073258)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (45223705..45252895)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4[+] T-cell exhaustion.
Title: BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4(+) T-cell exhaustion.
The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota.
Title: The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota.
Simultaneous transduction of dendritic cells with A20 and BTLA genes stimulates the development of stable and efficient tolerogenic dendritic cells and induces regulatory T cells.
Title: Simultaneous transduction of dendritic cells with A20 and BTLA genes stimulates the development of stable and efficient tolerogenic dendritic cells and induces regulatory T cells.
B and T lymphocyte attenuator regulates autophagy in mycobacterial infection via the AKT/mTOR signal pathway.
Title: B and T lymphocyte attenuator regulates autophagy in mycobacterial infection via the AKT/mTOR signal pathway.
these results suggest that BTLA functions as a cell-extrinsic suppressor of germinal center B cell lymphomagenesis
Title: The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.
Soluble BTLA is produced as a result of alternative RNA splicing. This isoform of BTLA has biological significance through changes in cellular proliferation and can predict the diagnosis of sepsis.
Title: Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness.
these data support a role of BTLA on type I NKT cells in limiting anti-tumor immunity.
Title: Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma.
these data indicate that HVEM/BTLA interactions are dispensable for the formation of de novo host antidonor isotype-specific antibodies following skin transplantation
Title: T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway.
The percentage of circulating BTLA+CD4+ lymphocytes was significantly higher in mice with LPS-induced acute lung inflammation.
Title: Expression of B and T Lymphocyte Attenuator in Patients with Severe Community-Acquired Pneumonia and the Effect of Steroid Therapy in a Mouse Model.
Dendritic cells require BTLA and HVEM to actively adjust tolerizing T cell responses under steady-state conditions.
Title: Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE692012 (e-PCR)
- UniSTS:209222

NoName (e-PCR)
- UniSTS:484996

11.MMHAP62FLD2.seq (e-PCR)
- UniSTS:123085

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response-regulating cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response-regulating cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: B- and T-lymphocyte attenuator

Names: B- and T-lymphocyte-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037719.2 → NP_001032808.2 B- and T-lymphocyte attenuator isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

AK041334, BB123968, BC108964

Consensus CDS

CCDS28195.1

UniProtKB/Swiss-Prot

Q7TSA3

UniProtKB/TrEMBL

E9QNY6

Related

ENSMUSP00000067877.5, ENSMUST00000063654.6

Conserved Domains (2) summary

smart00410
Location:50 → 142

IG_like; Immunoglobulin like

cl11960
Location:97 → 143

Ig; Immunoglobulin domain
NM_177584.3 → NP_808252.1 B- and T-lymphocyte attenuator isoform 2 precursor

See identical proteins and their annotated locations for NP_808252.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).

Source sequence(s)

AK041334, BB123968

Consensus CDS

CCDS28196.1

UniProtKB/Swiss-Prot

Q7TSA3

UniProtKB/TrEMBL

A0A0R4J1A0

Related

ENSMUSP00000099866.4, ENSMUST00000102802.10

Conserved Domains (2) summary

smart00410
Location:50 → 142

IG_like; Immunoglobulin like

cl11960
Location:97 → 143

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

45043121..45073258

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159833.1 → XP_036015726.1 B- and T-lymphocyte attenuator isoform X3

Conserved Domains (2) summary

cd00096
Location:42 → 47

Ig; Ig strand A [structural motif]

cl11960
Location:40 → 143

Ig; Immunoglobulin domain
XM_036159834.1 → XP_036015727.1 B- and T-lymphocyte attenuator isoform X3

Conserved Domains (2) summary

cd00096
Location:42 → 47

Ig; Ig strand A [structural motif]

cl11960
Location:40 → 143

Ig; Immunoglobulin domain
XM_006521907.5 → XP_006521970.1 B- and T-lymphocyte attenuator isoform X1
XM_006521908.5 → XP_006521971.1 B- and T-lymphocyte attenuator isoform X2