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Dhx37 DEAH-box helicase 37 [ Mus musculus (house mouse) ]

Gene ID: 208144, updated on 11-Apr-2024

Summary

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Official Symbol
Dhx37provided by MGI
Official Full Name
DEAH-box helicase 37provided by MGI
Primary source
MGI:MGI:3028576
See related
Ensembl:ENSMUSG00000029480 AllianceGenome:MGI:3028576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm451; Gm1050; mKIAA1517
Summary
Predicted to enable U3 snoRNA binding activity. Predicted to be involved in brain development; positive regulation of male gonad development; and ribosome biogenesis. Predicted to be located in cytoplasm and nuclear membrane. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 9.3), adrenal adult (RPKM 9.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dhx37 in Genome Data Viewer
Location:
5 G1.1; 5 64.2 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (125490811..125511203, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (125413747..125434139, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2179 Neighboring gene STARR-positive B cell enhancer ABC_E3623 Neighboring gene nuclear encoded tRNA aspartic acid 14 (anticodon GTC) Neighboring gene nuclear encoded tRNA alanine 5 (anticodon TGC) Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:125921729-125921912 Neighboring gene Bri3 binding protein Neighboring gene STARR-positive B cell enhancer ABC_E853 Neighboring gene predicted gene, 40325

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis. Boneberg FM, et al. RNA, 2019 Jun. PMID 30910870, Free PMC Article
  2. Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Sferruzzi-Perri AN, et al. Biol Reprod, 2009 Jul. PMID 19228596, Free PMC Article
  3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1517, MGC90028

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables U3 snoRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of male gonad development ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DHX37
Names
DEAH (Asp-Glu-Ala-His) box polypeptide 37
NP_976064.1
XP_017176254.1
XP_030110171.1
XP_036020844.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203319.2 → NP_976064.1  probable ATP-dependent RNA helicase DHX37

    See identical proteins and their annotated locations for NP_976064.1

    Status: VALIDATED

    Source sequence(s)
    AC138613
    Consensus CDS
    CCDS19685.1
    UniProtKB/TrEMBL
    Q5DTX1, Q6NZL1
    Related
    ENSMUSP00000131734.2, ENSMUST00000169485.6
    Conserved Domains (6) summary
    smart00490
    Location:578 → 667
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:761 → 852
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:236 → 1009
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:267 → 407
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam04408
    Location:730 → 781
    HA2; Helicase associated domain (HA2)
    pfam07717
    Location:887 → 1004
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RNA

  1. NR_184665.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138613

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    125490811..125511203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320765.2 → XP_017176254.1  probable ATP-dependent RNA helicase DHX37 isoform X1

    UniProtKB/TrEMBL
    Q5DTX1
    Conserved Domains (1) summary
    COG1643
    Location:236 → 1009
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  2. XM_030254311.2 → XP_030110171.1  probable ATP-dependent RNA helicase DHX37 isoform X2

    Conserved Domains (1) summary
    COG1643
    Location:1 → 607
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  3. XM_036164951.1 → XP_036020844.1  probable ATP-dependent RNA helicase DHX37 isoform X3

    Conserved Domains (1) summary
    COG1643
    Location:74 → 503
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_003955608.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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