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Zfp976 zinc finger protein 976 [ Mus musculus (house mouse) ]

Gene ID: 208111, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp976provided by MGI
Official Full Name
zinc finger protein 976provided by MGI
Primary source
MGI:MGI:3036263
See related
Ensembl:ENSMUSG00000074158 AllianceGenome:MGI:3036263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830147E19Rik; C330019L16Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to heat. Predicted to be active in nucleus. Orthologous to human ZNF101 (zinc finger protein 101) and ZNF699 (zinc finger protein 699). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Zfp976 in Genome Data Viewer
Location:
7 B3; 7 28.25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (42258938..42293684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (42609514..42644267, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18740 Neighboring gene STARR-seq mESC enhancer starr_18741 Neighboring gene predicted gene, 53386 Neighboring gene STARR-seq mESC enhancer starr_18742 Neighboring gene STARR-seq mESC enhancer starr_18744 Neighboring gene predicted gene, 21028 Neighboring gene zinc finger protein 977 Neighboring gene STARR-seq mESC enhancer starr_18745 Neighboring gene zinc finger protein 975 Neighboring gene STARR-seq mESC enhancer starr_18747 Neighboring gene predicted gene, 38998

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. Fujimoto M, et al. J Biol Chem, 2008 Oct 31. PMID 18755693, Free PMC Article
  2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242388.1 → NP_001229317.1  zinc finger protein-like

    Status: VALIDATED

    Source sequence(s)
    AC102628, AK141688, BP762393
    Consensus CDS
    CCDS57543.1
    UniProtKB/TrEMBL
    E9Q981
    Related
    ENSMUSP00000096105.3, ENSMUST00000098503.9
    Conserved Domains (5) summary
    smart00349
    Location:4 → 45
    KRAB; krueppel associated box
    COG5048
    Location:156 → 530
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553 → 573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 41
    KRAB; KRAB box
    pfam13465
    Location:481 → 506
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    42258938..42293684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322075.3 → XP_017177564.1  zinc finger protein-like isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:221 → 595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:590 → 610
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:69 → 109
    KRAB; KRAB box
    pfam13465
    Location:602 → 627
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001034857.3: Suppressed sequence

    Description
    NM_001034857.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version

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