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Pknox2 Pbx/knotted 1 homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 208076, updated on 21-Apr-2024

Summary

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Official Symbol
Pknox2provided by MGI
Official Full Name
Pbx/knotted 1 homeobox 2provided by MGI
Primary source
MGI:MGI:2445415
See related
Ensembl:ENSMUSG00000035934 AllianceGenome:MGI:2445415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prep2; D230005H23Rik
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; actin filament binding activity; and actin monomer binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in cytoplasm; cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human PKNOX2 (PBX/knotted 1 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 26.9), cortex adult (RPKM 10.3) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A4; 9 20.7 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (36802278..37058637, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (36890979..37147342, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26787 Neighboring gene etoposide induced 2.4 mRNA Neighboring gene predicted gene 27219 Neighboring gene STARR-seq mESC enhancer starr_23786 Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene STARR-seq mESC enhancer starr_23787 Neighboring gene predicted gene, 34652 Neighboring gene VISTA enhancer mm577 Neighboring gene predicted gene, 34538 Neighboring gene STARR-seq mESC enhancer starr_23793 Neighboring gene predicted gene, 48716 Neighboring gene STARR-positive B cell enhancer mm9_chr9:36984672-36984973 Neighboring gene STARR-positive B cell enhancer ABC_E249 Neighboring gene STARR-seq mESC enhancer starr_23796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:37038155-37038413 Neighboring gene transmembrane protein 218 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 2 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis. Miyake Y, et al. Biochem Biophys Res Commun, 2021 Sep 24. PMID 34311199
  2. Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export. Haller K, et al. J Biol Chem, 2004 Nov 19. PMID 15339927
  3. Prep2: cloning and expression of a new prep family member. Haller K, et al. Dev Dyn, 2002 Nov. PMID 12412021
  4. The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6. Antosova B, et al. PLoS Genet, 2016 Dec. PMID 27918583, Free PMC Article
  5. Dynamic expression of MEIS1 homeoprotein in E14.5 forebrain and differentiated forebrain-derived neural stem cells. Barber BA, et al. Ann Anat, 2013 Oct. PMID 23756022

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea.
    Title: Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea.
  2. PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis.
    Title: PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis.
  3. results indicated that Pknox2 misexpression affected mesenchymal condensation and early chondrogenic differentiation in the zeugopod skeletons of transgenic embryos
    Title: Misexpression of Pknox2 in mouse limb bud mesenchyme perturbs zeugopod development and deltoid crest formation.
  4. Prep2 functions to varying degrees in a broad array of tissues and developmental processes.
    Title: Prep2: cloning and expression of a new prep family member.
  5. transcriptional regulation by PREP2 is modulated through the subcellular distribution of multiple isoforms and by interaction with two distinct cytoskeletal systems
    Title: Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin monomer binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
homeobox protein PKNOX2
Names
PBX/knotted homeobox 2
homeobox protein PREP-2
homeodomain containing transcription factor PREP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029838.3 → NP_001025009.1  homeobox protein PKNOX2 isoform 1

    See identical proteins and their annotated locations for NP_001025009.1

    Status: VALIDATED

    Source sequence(s)
    AC164087, CT009699
    Consensus CDS
    CCDS22974.1
    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0
    Related
    ENSMUSP00000035806.6, ENSMUST00000039674.13
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  2. NM_001424685.1 → NP_001411614.1  homeobox protein PKNOX2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164087, CT009699
    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0

  3. NM_001424686.1 → NP_001411615.1  homeobox protein PKNOX2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164087, CT009699
    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0

  4. NM_001424687.1 → NP_001411616.1  homeobox protein PKNOX2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164087, CT009699

  5. NM_001424688.1 → NP_001411617.1  homeobox protein PKNOX2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC164087, CT009699

  6. NM_001424689.1 → NP_001411618.1  homeobox protein PKNOX2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC164087, CT009699

  7. NM_001424690.1 → NP_001411619.1  homeobox protein PKNOX2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC164087, CT009699

  8. NM_148950.4 → NP_683752.2  homeobox protein PKNOX2 isoform 1

    See identical proteins and their annotated locations for NP_683752.2

    Status: VALIDATED

    Source sequence(s)
    AC164087, CT009699
    Consensus CDS
    CCDS22974.1
    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0
    Related
    ENSMUSP00000079578.6, ENSMUST00000080754.12
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    36802278..37058637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154763.1 → XP_036010656.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  2. XM_006510126.5 → XP_006510189.1  homeobox protein PKNOX2 isoform X1

    See identical proteins and their annotated locations for XP_006510189.1

    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  3. XM_006510125.5 → XP_006510188.1  homeobox protein PKNOX2 isoform X1

    See identical proteins and their annotated locations for XP_006510188.1

    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  4. XM_036154762.1 → XP_036010655.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  5. XM_036154764.1 → XP_036010657.1  homeobox protein PKNOX2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  6. XM_006510127.5 → XP_006510190.1  homeobox protein PKNOX2 isoform X1

    See identical proteins and their annotated locations for XP_006510190.1

    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG

  7. XM_006510124.5 → XP_006510187.1  homeobox protein PKNOX2 isoform X1

    See identical proteins and their annotated locations for XP_006510187.1

    UniProtKB/Swiss-Prot
    Q8BG99, Q8R4B0
    Conserved Domains (3) summary
    pfam05920
    Location:306 → 345
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 181
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    NF033760
    Location:5 → 77
    gliding_GltG; adventurous gliding motility protein GltG
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG99.1 GenPept UniProtKB/Swiss-Prot:Q8BG99

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