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Alg11 ALG11 alpha-1,2-mannosyltransferase [ Mus musculus (house mouse) ]

Gene ID: 207958, updated on 11-Apr-2024

Summary

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Official Symbol
Alg11provided by MGI
Official Full Name
ALG11 alpha-1,2-mannosyltransferaseprovided by MGI
Primary source
MGI:MGI:2142632
See related
Ensembl:ENSMUSG00000063362 AllianceGenome:MGI:2142632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mmat-4(5); B230397C21
Summary
Predicted to enable GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and respiratory system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ip. Orthologous to human ALG11 (ALG11 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 5.0), bladder adult (RPKM 4.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A2; 8 10.92 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22550731..22561643)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22060721..22071627)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 70 Neighboring gene STARR-seq mESC enhancer starr_20896 Neighboring gene ATPase, Cu++ transporting, beta polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E2858 Neighboring gene STARR-seq mESC enhancer starr_20897 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 5 Neighboring gene STARR-seq mESC enhancer starr_20898 Neighboring gene predicted gene, 57529 Neighboring gene STARR-seq mESC enhancer starr_20899 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 3 Neighboring gene STARR-seq mESC enhancer starr_20900

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and transcriptional expression of mouse mannosyltransferase IV/V cDNA, which is involved in the synthesis of lipid-linked oligosaccharides. Nishimura Y, et al. Biosci Biotechnol Biochem, 2014. PMID 25036826
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hence, we concluded that there is different transcriptional control mechanism between mALG11 and hALG11
    Title: Cloning and transcriptional expression of mouse mannosyltransferase IV/V cDNA, which is involved in the synthesis of lipid-linked oligosaccharides.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in oligosaccharide-lipid intermediate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Names
asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)
asparagine-linked glycosylation 11 homolog (yeast, alpha-1,2-mannosyltransferase)
asparagine-linked glycosylation protein 11 homolog
defective mannosyltransferase IV(V)
glycolipid 2-alpha-mannosyltransferase
mannosyltransferase IV(V)
NP_001230090.1
NP_898965.1
XP_006509108.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243161.1 → NP_001230090.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001230090.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK157746, BC061469
    Consensus CDS
    CCDS57613.1
    UniProtKB/Swiss-Prot
    Q3TZM9, Q6P7W8, Q8BL38
    UniProtKB/TrEMBL
    A0A077K846
    Related
    ENSMUSP00000072382.7, ENSMUST00000072572.13
    Conserved Domains (2) summary
    cd03806
    Location:64 → 480
    GT1_ALG11_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown ...
    PLN02949
    Location:64 → 492
    PLN02949; transferase, transferring glycosyl groups

  2. NM_183142.4 → NP_898965.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform 2

    See identical proteins and their annotated locations for NP_898965.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK046475, AK157746, BC061469
    Consensus CDS
    CCDS40292.1
    UniProtKB/Swiss-Prot
    Q3TZM9
    Related
    ENSMUSP00000106365.3, ENSMUST00000110737.3
    Conserved Domains (2) summary
    cd03806
    Location:64 → 438
    GT1_ALG11_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown ...
    PLN02949
    Location:64 → 450
    PLN02949; transferase, transferring glycosyl groups

RNA

  1. NR_040650.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site that introduces a premature stop codon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK157746, BC061469

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22550731..22561643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509045.3 → XP_006509108.1  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase isoform X1

    Conserved Domains (1) summary
    cd03806
    Location:39 → 455
    GT4_ALG11-like; alpha-1,2-mannosyltransferase ALG11 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TZM9.1 GenPept UniProtKB/Swiss-Prot:Q3TZM9

Gene LinkOut

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