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C2cd2 C2 calcium-dependent domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 207781, updated on 5-Mar-2024

Summary

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Official Symbol
C2cd2provided by MGI
Official Full Name
C2 calcium-dependent domain containing 2provided by MGI
Primary source
MGI:MGI:1891883
See related
Ensembl:ENSMUSG00000045975 AllianceGenome:MGI:1891883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORF25; mKIAA4045; 5730563M15; 5830404H04Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human C2CD2 (C2 calcium dependent domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 11.5), placenta adult (RPKM 3.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C4; 16 57.7 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97656409..97727248, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97855209..97925795, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene receptor-interacting serine-threonine kinase 4 Neighboring gene STARR-seq mESC enhancer starr_41639 Neighboring gene PR domain containing 15 Neighboring gene STARR-seq mESC enhancer starr_41640 Neighboring gene microRNA 6964 Neighboring gene zinc finger and BTB domain containing 21 Neighboring gene predicted gene, 53924 Neighboring gene RIKEN cDNA C030010L15 gene Neighboring gene RIKEN cDNA B230307C23 gene Neighboring gene STARR-positive B cell enhancer ABC_E9939

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome. Akeson EC, et al. Cytogenet Cell Genet, 2001. PMID 11528125
  2. Evolutionary breakpoints on human chromosome 21. Davisson MT, et al. Genomics, 2001 Nov. PMID 11707078
  3. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  4. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
  5. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • KIAA4045

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C2 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174847.2 → NP_777272.2  C2 domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AA024193, AA137897, AK077731, AK080956, AK086520, AK220454, AV241091, BB005022, CB202385, CF616821, CF734597
    Consensus CDS
    CCDS28361.1
    UniProtKB/Swiss-Prot
    E9Q3C1, Q3TE01, Q3UP20, Q5DTR6, Q80XM8
    Related
    ENSMUSP00000127368.2, ENSMUST00000170757.3
    Conserved Domains (2) summary
    cd21682
    Location:53 → 230
    SMP_C2CD2; synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 domain-containing protein 2 (C2CD2)
    cl14603
    Location:261 → 386
    C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    97656409..97727248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246109.4 → XP_011244411.1  C2 domain-containing protein 2 isoform X1

    Conserved Domains (2) summary
    pfam18696
    Location:71 → 221
    SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
    cl14603
    Location:260 → 385
    C2; C2 domain

  2. XM_036159830.1 → XP_036015723.1  C2 domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    pfam18696
    Location:71 → 223
    SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
    cl14603
    Location:261 → 386
    C2; C2 domain

  3. XM_036159829.1 → XP_036015722.1  C2 domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    pfam18696
    Location:71 → 223
    SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
    cl14603
    Location:261 → 386
    C2; C2 domain

  4. XM_011246111.2 → XP_011244413.1  C2 domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    cl14603
    Location:59 → 184
    C2; C2 domain

  5. XM_017316901.3 → XP_017172390.1  C2 domain-containing protein 2 isoform X5

    Conserved Domains (2) summary
    pfam18696
    Location:71 → 222
    SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
    cl14603
    Location:261 → 386
    C2; C2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q3C1.1 GenPept UniProtKB/Swiss-Prot:E9Q3C1

Gene LinkOut

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