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Sqle squalene epoxidase [ Mus musculus (house mouse) ]

Gene ID: 20775, updated on 21-Apr-2024

Summary

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Official Symbol
Sqleprovided by MGI
Official Full Name
squalene epoxidaseprovided by MGI
Primary source
MGI:MGI:109296
See related
Ensembl:ENSMUSG00000022351 AllianceGenome:MGI:109296
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable FAD binding activity and squalene monooxygenase activity. Predicted to be involved in several processes, including lipid droplet formation; regulation of cell population proliferation; and sterol metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human SQLE (squalene epoxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 52.8), whole brain E14.5 (RPKM 35.8) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D1; 15 25.16 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (59186941..59203042)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (59315092..59331193)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36617 Neighboring gene STARR-seq mESC enhancer starr_38779 Neighboring gene STARR-seq mESC enhancer starr_38780 Neighboring gene zinc finger protein 572 Neighboring gene WASH complex subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E8593 Neighboring gene STARR-seq mESC enhancer starr_38785 Neighboring gene NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase Neighboring gene STARR-seq mESC enhancer starr_38787 Neighboring gene STARR-seq mESC enhancer starr_38788 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59356284-59356467 Neighboring gene STARR-seq mESC enhancer starr_38791 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59403555-59403708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59429020-59429203 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:59429225-59429438

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis. Li C, et al. Gut, 2022 Nov. PMID 35232776, Free PMC Article
  2. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Xia F, et al. Endocrinology, 2008 Oct. PMID 18599549
  3. Promoter analysis of the murine squalene epoxidase gene. Identification of a 205 bp homing region regulated by both SREBP'S and NF-Y. Murphy C, et al. Biochim Biophys Acta, 2006 Oct. PMID 17027328
  4. The first step of oxygenation in cholesterol biosynthesis. Ono T. Biochem Biophys Res Commun, 2002 Apr 19. PMID 11969229
  5. Nucleotide sequence of a cDNA for mouse squalene epoxidase. Kosuga K, et al. Biochim Biophys Acta, 1995 Feb 21. PMID 7873613

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of squalene epoxidase linking with PI3K/AKT signaling pathway suppresses endometrial cancer.
    Title: Inhibition of squalene epoxidase linking with PI3K/AKT signaling pathway suppresses endometrial cancer.
  2. Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.
    Title: Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.
  3. Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis.
    Title: Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis.
  4. results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.
    Title: Promoter analysis of the murine squalene epoxidase gene. Identification of a 205 bp homing region regulated by both SREBP'S and NF-Y.
  5. Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.
    Title: Microarray gene expression analysis of the Fob3b obesity QTL identifies positional candidate gene Sqle and perturbed cholesterol and glycolysis pathways.
  6. Requires a redox partner, but cytochrome p450 reductase is not the only microsomal reductase that will serve this purpose.
    Title: Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables squalene monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables squalene monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
squalene monooxygenase
Names
SE
NP_033296.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009270.3 → NP_033296.1  squalene monooxygenase

    See identical proteins and their annotated locations for NP_033296.1

    Status: PROVISIONAL

    Source sequence(s)
    AC113269
    Consensus CDS
    CCDS27497.1
    UniProtKB/Swiss-Prot
    P52019
    UniProtKB/TrEMBL
    Q3TQK8, Q3TSS7
    Related
    ENSMUSP00000022977.8, ENSMUST00000022977.14
    Conserved Domains (2) summary
    COG0654
    Location:123 → 497
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:275 → 546
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    59186941..59203042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52019.1 GenPept UniProtKB/Swiss-Prot:P52019

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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