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Rnf43 ring finger protein 43 [ Mus musculus (house mouse) ]

Gene ID: 207742, updated on 22-Apr-2024

Summary

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Official Symbol
Rnf43provided by MGI
Official Full Name
ring finger protein 43provided by MGI
Primary source
MGI:MGI:2442609
See related
Ensembl:ENSMUSG00000034177 AllianceGenome:MGI:2442609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732452J19Rik
Summary
Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in negative regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in endoplasmic reticulum; nucleus; and plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in alimentary system; genitourinary system; and lung. Orthologous to human RNF43 (ring finger protein 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 7.3), colon adult (RPKM 5.7) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 52.17 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87553913..87626365)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87663087..87735539)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E68 Neighboring gene STARR-seq mESC enhancer starr_30293 Neighboring gene myotubularin related protein 4 Neighboring gene heat shock transcription factor family member 5 Neighboring gene STARR-positive B cell enhancer ABC_E5260 Neighboring gene STARR-seq mESC enhancer starr_30296 Neighboring gene RIKEN cDNA 1110028F11 gene Neighboring gene predicted gene, 25968 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87534506-87534735 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87539623-87539928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87547776-87547885 Neighboring gene STARR-positive B cell enhancer ABC_E7039 Neighboring gene STARR-positive B cell enhancer ABC_E1838 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87563093-87563276 Neighboring gene SPT4A, DSIF elongation factor subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87565164-87565417 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87568144-87568342 Neighboring gene STARR-positive B cell enhancer ABC_E8440 Neighboring gene microRNA 142b Neighboring gene microRNA 142

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. JAK-STAT1 Signaling Pathway Is an Early Response to Helicobacter pylori Infection and Contributes to Immune Escape and Gastric Carcinogenesis. Li X, et al. Int J Mol Sci, 2022 Apr 8. PMID 35456965, Free PMC Article
  2. Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation. Zhou X, et al. Animal Model Exp Med, 2022 Feb. PMID 35229994, Free PMC Article
  3. Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma. Hosein AN, et al. Gastroenterology, 2022 Apr. PMID 34973294, Free PMC Article
  4. A DNA repair player, ring finger protein 43, relieves etoposide-induced topoisomerase II poisoning. Lerksuthirat T, et al. Genes Cells, 2020 Nov. PMID 32939879
  5. Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma. Li Y, et al. Protein Cell, 2020 Apr. PMID 32008206, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer.
    Title: Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer.
  2. RNF43 induces the turnover of protease-activated receptor 2 in colon cancer.
    Title: RNF43 induces the turnover of protease-activated receptor 2 in colon cancer.
  3. Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.
    Title: Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.
  4. RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
    Title: RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
  5. Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response.
    Title: Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response.
  6. Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation.
    Title: Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation.
  7. ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
    Title: ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
  8. A DNA repair player, ring finger protein 43, relieves etoposide-induced topoisomerase II poisoning.
    Title: A DNA repair player, ring finger protein 43, relieves etoposide-induced topoisomerase II poisoning.
  9. Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.
    Title: Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.
  10. A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
    Title: A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt receptor catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Wnt receptor catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF43
Names
RING-type E3 ubiquitin transferase RNF43
NP_001350366.1
NP_766036.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363437.1 → NP_001350366.1  E3 ubiquitin-protein ligase RNF43 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK028750, AL604022
    Consensus CDS
    CCDS88216.1
    UniProtKB/TrEMBL
    A3KMI3, E9PWJ5
    Related
    ENSMUSP00000044241.5, ENSMUST00000040089.5
    Conserved Domains (2) summary
    cd16798
    Location:143 → 189
    RING-H2_RNF43; RING finger, H2 subclass, found in RING finger protein 43 (RNF43) and similar proteins
    cl28271
    Location:472 → 629
    dnaA; chromosomal replication initiation protein; Provisional

  2. NM_172448.4 → NP_766036.2  E3 ubiquitin-protein ligase RNF43 isoform 1 precursor

    See identical proteins and their annotated locations for NP_766036.2

    Status: VALIDATED

    Source sequence(s)
    AK032782, BC131957, CF747567
    Consensus CDS
    CCDS25215.2
    UniProtKB/Swiss-Prot
    B2KGH3, Q5NCP0, Q6DI76, Q8BME0, Q8C191, Q8K0X4
    UniProtKB/TrEMBL
    E9PWJ5
    Related
    ENSMUSP00000130685.2, ENSMUST00000165679.8
    Conserved Domains (1) summary
    pfam13639
    Location:270 → 312
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87553913..87626365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NCP0.1 GenPept UniProtKB/Swiss-Prot:Q5NCP0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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