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Igsf11 immunoglobulin superfamily, member 11 [ Mus musculus (house mouse) ]

Gene ID: 207683, updated on 11-Apr-2024

Summary

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Official Symbol
Igsf11provided by MGI
Official Full Name
immunoglobulin superfamily, member 11provided by MGI
Primary source
MGI:MGI:2388477
See related
Ensembl:ENSMUSG00000022790 AllianceGenome:MGI:2388477
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Igsf13; BT-IgSF; 1700025L02Rik
Summary
Predicted to enable ionotropic glutamate receptor binding activity. Involved in positive regulation of long-term synaptic potentiation. Predicted to be located in several cellular components, including cell-cell junction; excitatory synapse; and postsynaptic density. Is expressed in several structures, including adrenal gland; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human IGSF11 (immunoglobulin superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 19.9), kidney adult (RPKM 17.5) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B4; 16 26.87 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38712840..38847521)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38892476..39027159)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40835 Neighboring gene STARR-seq mESC enhancer starr_40836 Neighboring gene testis expressed 55 Neighboring gene predicted gene 15802 Neighboring gene predicted gene, 22500 Neighboring gene predicted gene, 34258 Neighboring gene STARR-positive B cell enhancer mm9_chr16:39052733-39053034 Neighboring gene STARR-seq mESC enhancer starr_40838 Neighboring gene predicted gene, 36585 Neighboring gene predicted gene, 36742

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test. Montag D, et al. PLoS One, 2023. PMID 36607983, Free PMC Article
  2. IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95. Kim H, et al. Bone Res, 2020. PMID 32047704, Free PMC Article
  3. Promotion of differentiation in developing mouse cerebellar granule cells by a cell adhesion molecule BT-IgSF. Higashine K, et al. Neurosci Lett, 2018 Nov 1. PMID 30176341
  4. Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis. Suzu S, et al. Biochem Biophys Res Commun, 2002 Sep 6. PMID 12207903
  5. IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. Joustra SD, et al. J Clin Endocrinol Metab, 2020 Mar 1. PMID 31650157, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes.
    Title: IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes.
  2. Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test.
    Title: Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test.
  3. IGSF11 is required for pericentric heterochromatin dissociation during meiotic diplotene.
    Title: IGSF11 is required for pericentric heterochromatin dissociation during meiotic diplotene.
  4. somatotrope neurosecretory hyperfunction in IGSF1-deficient humans and mice.
    Title: IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction.
  5. that BT-IgSF is one of the important cell adhesion molecules that regulate the developmentof mouse cerebellum
    Title: Promotion of differentiation in developing mouse cerebellar granule cells by a cell adhesion molecule BT-IgSF.
  6. Molecular cloning of BT-IgSF which is preferentially expressed by brain and testis
    Title: Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of protein location ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mini excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trans-synaptic signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in trans-synaptic signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily member 11
Names
brain and testis-specific immunoglobulin superfamily protein
immunoglobulin superfamily, member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_170599.2 → NP_733548.2  immunoglobulin superfamily member 11 precursor

    See identical proteins and their annotated locations for NP_733548.2

    Status: PROVISIONAL

    Source sequence(s)
    BC057555
    Consensus CDS
    CCDS28175.1
    UniProtKB/Swiss-Prot
    P0C673
    Related
    ENSMUSP00000023478.8, ENSMUST00000023478.8
    Conserved Domains (3) summary
    smart00410
    Location:157 → 232
    IG_like; Immunoglobulin like
    pfam07686
    Location:27 → 141
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:158 → 223
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    38712840..38847521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245851.2 → XP_011244153.1  immunoglobulin superfamily member 11 isoform X1

    See identical proteins and their annotated locations for XP_011244153.1

    UniProtKB/TrEMBL
    D3Z6S7
    Conserved Domains (3) summary
    pfam13927
    Location:88 → 160
    Ig_3; Immunoglobulin domain
    cd00096
    Location:13 → 18
    Ig; Ig strand C' [structural motif]
    cl11960
    Location:5 → 67
    Ig; Immunoglobulin domain

  2. XM_036159828.1 → XP_036015721.1  immunoglobulin superfamily member 11 isoform X1

    UniProtKB/TrEMBL
    D3Z6S7
    Related
    ENSMUSP00000110354.2, ENSMUST00000114706.8
    Conserved Domains (3) summary
    pfam13927
    Location:88 → 160
    Ig_3; Immunoglobulin domain
    cd00096
    Location:13 → 18
    Ig; Ig strand C' [structural motif]
    cl11960
    Location:5 → 67
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C673.1 GenPept UniProtKB/Swiss-Prot:P0C673

Gene LinkOut

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