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Sprr3 small proline-rich protein 3 [ Mus musculus (house mouse) ]

Gene ID: 20766, updated on 8-Feb-2024

Summary

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Official Symbol
Sprr3provided by MGI
Official Full Name
small proline-rich protein 3provided by MGI
Primary source
MGI:MGI:1330237
See related
Ensembl:ENSMUSG00000045539 AllianceGenome:MGI:1330237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPR3
Summary
Predicted to be involved in peptide cross-linking. Predicted to act upstream of or within keratinization. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and thymus. Orthologous to human SPRR3 (small proline rich protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward stomach adult (RPKM 766.4) See more
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Genomic context

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Location:
3 F1; 3 40.14 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (92363809..92366027, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (92456502..92458720, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene small proline-rich protein 2K Neighboring gene small proline-rich protein 1B Neighboring gene small proline-rich protein 1A Neighboring gene small proline-rich protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Small proline-rich repeat 3 is a novel coordinator of PDGFRβ and integrin β1 crosstalk to augment proliferation and matrix synthesis by cardiac fibroblasts. Saraswati S, et al. FASEB J, 2020 Jun. PMID 32297675, Free PMC Article
  2. Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells. Segedy AK, et al. Arterioscler Thromb Vasc Biol, 2014 Dec. PMID 25278290, Free PMC Article
  3. Exogenous expression of Esophagin/SPRR3 attenuates the tumorigenicity of esophageal squamous cell carcinoma cells via promoting apoptosis. Zhang Y, et al. Int J Cancer, 2008 Jan 15. PMID 17935133
  4. Small proline-rich proteins are cross-bridging proteins in the cornified cell envelopes of stratified squamous epithelia. Steinert PM, et al. J Struct Biol, 1998. PMID 9724607
  5. Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein. Steinert PM, et al. Cell Death Differ, 1999 Sep. PMID 10510474

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SPRR3 protects an atheroma lesion from vascular smooth muscle cell (VSMC) loss by promoting survival signaling in plaque VSMCs, thereby significantly decreasing atherosclerosis progression.
    Title: Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells.
  2. These data suggest that SPRR3 may play a role in vascular smooth muscle cells adaptation to local biomechanical stress within the plaque microenvironment.
    Title: Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.
  3. Esophagin/SPRR3 may play a role in the maintenance of normal esophageal epithelial homeostasis, and aberrant expression of Esophagin/SPRR3 may contribute to the tumorigenesis of esophageal squamous cell carcinoma
    Title: Exogenous expression of Esophagin/SPRR3 attenuates the tumorigenicity of esophageal squamous cell carcinoma cells via promoting apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within keratinization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small proline-rich protein 3
Names
cornifin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204427.1 → NP_001191356.1  small proline-rich protein 3

    See identical proteins and their annotated locations for NP_001191356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC127036
    Consensus CDS
    CCDS17558.1
    UniProtKB/Swiss-Prot
    O09116, Q059J8
    Conserved Domains (1) summary
    pfam02389
    Location:17 → 149
    Cornifin; Cornifin (SPRR) family

  2. NM_011478.2 → NP_035608.1  small proline-rich protein 3

    See identical proteins and their annotated locations for NP_035608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC125629, BY709657, EH099911
    Consensus CDS
    CCDS17558.1
    UniProtKB/Swiss-Prot
    O09116, Q059J8
    Related
    ENSMUSP00000056287.4, ENSMUST00000058142.4
    Conserved Domains (1) summary
    pfam02389
    Location:17 → 149
    Cornifin; Cornifin (SPRR) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    92363809..92366027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09116.1 GenPept UniProtKB/Swiss-Prot:O09116

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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