U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tbc1d16 TBC1 domain family, member 16 [ Mus musculus (house mouse) ]

Gene ID: 207592, updated on 30-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Tbc1d16provided by MGI
Official Full Name
TBC1 domain family, member 16provided by MGI
Primary source
MGI:MGI:2652878
See related
Ensembl:ENSMUSG00000039976 AllianceGenome:MGI:2652878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcd1d16; B930087K01
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and regulation of receptor recycling. Predicted to be located in cytosol. Predicted to be active in early endosome. Orthologous to human TBC1D16 (TBC1 domain family member 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 26.7), whole brain E14.5 (RPKM 24.4) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 E2; 11 83.34 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119033869..119119354, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119143043..119228503, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7107 Neighboring gene STARR-positive B cell enhancer ABC_E7108 Neighboring gene predicted gene 11754 Neighboring gene predicted gene, 35878 Neighboring gene STARR-positive B cell enhancer ABC_E7109 Neighboring gene predicted gene 11755 Neighboring gene STARR-positive B cell enhancer ABC_E1853 Neighboring gene STARR-positive B cell enhancer ABC_E7110 Neighboring gene microRNA 6934 Neighboring gene STARR-seq mESC enhancer starr_31313 Neighboring gene predicted gene 11753 Neighboring gene predicted gene, 36111 Neighboring gene STARR-seq mESC enhancer starr_31314 Neighboring gene coiled-coil domain containing 40 Neighboring gene predicted gene, 35932 Neighboring gene predicted gene, 46303

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TBC1 domain family member 16

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347625.1 → NP_001334554.1  TBC1 domain family member 16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL662835, AL672140, BE996705
    Consensus CDS
    CCDS83940.1
    UniProtKB/TrEMBL
    Q6PFC0, Q8BXD8
    Related
    ENSMUSP00000147182.2, ENSMUST00000207655.2

  2. NM_172443.3 → NP_766031.2  TBC1 domain family member 16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK047555, AL662835, BQ831250, CJ111152
    Consensus CDS
    CCDS25711.1
    UniProtKB/TrEMBL
    A2ABG4, Q8BXD8
    Related
    ENSMUSP00000048516.4, ENSMUST00000036113.4
    Conserved Domains (1) summary
    smart00164
    Location:423 → 651
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119033869..119119354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245739.2 → XP_030101599.1  TBC1 domain family member 16 isoform X4

    UniProtKB/TrEMBL
    Q8BXD8
    Conserved Domains (1) summary
    smart00164
    Location:437 → 665
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. XM_006532694.3 → XP_006532757.1  TBC1 domain family member 16 isoform X2

    UniProtKB/TrEMBL
    Q8BXD8
    Conserved Domains (1) summary
    smart00164
    Location:438 → 666
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  3. XM_006532695.3 → XP_006532758.1  TBC1 domain family member 16 isoform X3

    UniProtKB/TrEMBL
    Q8BXD8
    Conserved Domains (1) summary
    smart00164
    Location:438 → 666
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  4. XM_006532693.3 → XP_006532756.1  TBC1 domain family member 16 isoform X1

    UniProtKB/TrEMBL
    Q8BXD8
    Conserved Domains (1) summary
    smart00164
    Location:439 → 667
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  5. XM_030245742.2 → XP_030101602.1  TBC1 domain family member 16 isoform X7

    UniProtKB/TrEMBL
    Q8BXD8
    Conserved Domains (1) summary
    smart00164
    Location:358 → 586
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  6. XM_030245743.2 → XP_030101603.1  TBC1 domain family member 16 isoform X8

    UniProtKB/TrEMBL
    Q8BXD8
    Conserved Domains (1) summary
    smart00164
    Location:357 → 585
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  7. XM_030245741.2 → XP_030101601.1  TBC1 domain family member 16 isoform X6

    UniProtKB/TrEMBL
    Q8BXD8
    Conserved Domains (1) summary
    smart00164
    Location:373 → 601
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  8. XM_030245740.2 → XP_030101600.1  TBC1 domain family member 16 isoform X5

    UniProtKB/TrEMBL
    Q8BXD8
    Conserved Domains (1) summary
    smart00164
    Location:374 → 602
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous