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Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta [ Mus musculus (house mouse) ]

Gene ID: 207565, updated on 23-Apr-2024

Summary

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Official Symbol
Camkk2provided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase kinase 2, betaprovided by MGI
Primary source
MGI:MGI:2444812
See related
Ensembl:ENSMUSG00000029471 AllianceGenome:MGI:2444812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0787; 6330570N16Rik
Summary
Predicted to enable calcium ion binding activity; calmodulin binding activity; and calmodulin-dependent protein kinase activity. Predicted to be involved in CAMKK-AMPK signaling cascade; activation of protein kinase activity; and protein autophosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol. Is expressed in nervous system; neural retina; and testis. Orthologous to human CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 29.2), cerebellum adult (RPKM 25.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 62.55 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122856064..122918295, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122718380..122779522, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 7 Neighboring gene microRNA 8115 Neighboring gene STARR-seq mESC enhancer starr_14295 Neighboring gene predicted gene 10064 Neighboring gene purinergic receptor P2X, ligand-gated ion channel 4 Neighboring gene STARR-positive B cell enhancer ABC_E3614 Neighboring gene STARR-seq mESC enhancer starr_14298 Neighboring gene anaphase-promoting complex subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E10348 Neighboring gene STARR-positive B cell enhancer ABC_E1307 Neighboring gene STARR-positive B cell enhancer ABC_E2762 Neighboring gene predicted gene, 33044

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells. Juras PK, et al. Cancer Immunol Res, 2023 Jan 3. PMID 36301267, Free PMC Article
  2. Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy. Lee A, et al. Nat Commun, 2022 Aug 1. PMID 35915085, Free PMC Article
  3. Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions in Prostate Cancer. Pulliam TL, et al. Cells, 2022 Jun 10. PMID 35741020, Free PMC Article
  4. Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism. Stork BA, et al. Mol Metab, 2022 Aug. PMID 35562082, Free PMC Article
  5. CaMKK2 Knockout Bone Marrow Cells Collected/Processed in Low Oxygen (Physioxia) Suggests CaMKK2 as a Hematopoietic Stem to Progenitor Differentiation Fate Determinant. Broxmeyer HE, et al. Stem Cell Rev Rep, 2022 Oct. PMID 35262902, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
    Title: Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
  2. Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin.
    Title: Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin.
  3. CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle.
    Title: CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle.
  4. Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells.
    Title: Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells.
  5. CaMKK2 Knockout Bone Marrow Cells Collected/Processed in Low Oxygen (Physioxia) Suggests CaMKK2 as a Hematopoietic Stem to Progenitor Differentiation Fate Determinant.
    Title: CaMKK2 Knockout Bone Marrow Cells Collected/Processed in Low Oxygen (Physioxia) Suggests CaMKK2 as a Hematopoietic Stem to Progenitor Differentiation Fate Determinant.
  6. Abeta42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy.
    Title: Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy.
  7. Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism.
    Title: Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism.
  8. Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions in Prostate Cancer.
    Title: Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions in Prostate Cancer.
  9. A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling.
    Title: A molecular complex of Ca(v)1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling.
  10. microRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism.
    Title: microRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CAMKK-AMPK signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CAMKK-AMPK signaling cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase kinase 2
Names
caM-KK 2
caM-KK beta
caM-kinase kinase 2
caM-kinase kinase beta
caMKK 2
caMKK beta
calcium/calmodulin-dependent protein kinase kinase beta
NP_001186605.1
NP_663333.1
XP_006530293.1
XP_006530294.1
XP_006530295.1
XP_006530296.1
XP_006530297.1
XP_006530298.1
XP_006530299.1
XP_017176252.1
XP_030110166.1
XP_030110167.1
XP_036020841.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199676.1 → NP_001186605.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_001186605.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC115728, AK031399, AK032070, AK042935, AW045178
    Consensus CDS
    CCDS80395.1
    UniProtKB/Swiss-Prot
    Q80TS0, Q8BXM8, Q8C078, Q8C0G3, Q8CH42, Q8QZT7
    Related
    ENSMUSP00000107297.5, ENSMUST00000111668.8
    Conserved Domains (1) summary
    cl21453
    Location:162 → 447
    PKc_like; Protein Kinases, catalytic domain

  2. NM_145358.2 → NP_663333.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_663333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region which shifts the reading frame, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC115728, AK031399, AK042935, AW045178, CK625345
    Consensus CDS
    CCDS19655.1
    UniProtKB/Swiss-Prot
    Q8C078
    Related
    ENSMUSP00000143732.2, ENSMUST00000200109.5
    Conserved Domains (2) summary
    smart00220
    Location:165 → 446
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:162 → 447
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122856064..122918295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530234.5 → XP_006530297.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:162 → 447
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030254306.2 → XP_030110166.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:162 → 442
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006530235.5 → XP_006530298.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:162 → 442
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006530233.5 → XP_006530296.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:162 → 442
    PKc_like; Protein Kinases, catalytic domain

  5. XM_017320763.3 → XP_017176252.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2

    UniProtKB/Swiss-Prot
    Q80TS0, Q8BXM8, Q8C078, Q8C0G3, Q8CH42, Q8QZT7
    Conserved Domains (1) summary
    cl21453
    Location:162 → 447
    PKc_like; Protein Kinases, catalytic domain

  6. XM_030254307.1 → XP_030110167.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X9

    Conserved Domains (1) summary
    cl21453
    Location:1 → 255
    PKc_like; Protein Kinases, catalytic domain

  7. XM_036164948.1 → XP_036020841.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X10

    Conserved Domains (1) summary
    cl21453
    Location:1 → 255
    PKc_like; Protein Kinases, catalytic domain

  8. XM_006530230.5 → XP_006530293.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006530293.1

    UniProtKB/Swiss-Prot
    Q8C078
    Conserved Domains (1) summary
    cl21453
    Location:162 → 447
    PKc_like; Protein Kinases, catalytic domain

  9. XM_006530231.5 → XP_006530294.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006530294.1

    UniProtKB/Swiss-Prot
    Q8C078
    Conserved Domains (1) summary
    cl21453
    Location:162 → 447
    PKc_like; Protein Kinases, catalytic domain

  10. XM_006530236.5 → XP_006530299.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JET2
    Related
    ENSMUSP00000142896.2, ENSMUST00000198029.5
    Conserved Domains (1) summary
    cl21453
    Location:1 → 255
    PKc_like; Protein Kinases, catalytic domain

  11. XM_006530232.5 → XP_006530295.1  calcium/calmodulin-dependent protein kinase kinase 2 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:162 → 442
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C078.2 GenPept UniProtKB/Swiss-Prot:Q8C078

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