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Spp1 secreted phosphoprotein 1 [ Mus musculus (house mouse) ]

Gene ID: 20750, updated on 5-Mar-2024

Summary

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Official Symbol
Spp1provided by MGI
Official Full Name
secreted phosphoprotein 1provided by MGI
Primary source
MGI:MGI:98389
See related
Ensembl:ENSMUSG00000029304 AllianceGenome:MGI:98389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OP; 2AR; Bsp; Eta; Opn; Ric; BNSP; BSPI; Opnl; Apl-1; ETA-1; Spp-1
Summary
Enables extracellular matrix binding activity. Acts upstream of or within several processes, including cellular ion homeostasis; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 580.4), liver E18 (RPKM 36.2) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
5 E5; 5 50.68 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104582977..104588919)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (104435111..104441053)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Ibsp 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_13823 Neighboring gene integrin binding sialoprotein Neighboring gene predicted gene, 54330 Neighboring gene matrix extracellular phosphoglycoprotein with ASARM motif (bone) Neighboring gene Spp1 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_13825 Neighboring gene STARR-seq mESC enhancer starr_13829 Neighboring gene STARR-seq mESC enhancer starr_13830 Neighboring gene polycystin 2, transient receptor potential cation channel Neighboring gene THO complex subunit 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma. Digifico E, et al. Front Immunol, 2023. PMID 37398648, Free PMC Article
  2. Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis. Rentsendorj A, et al. Front Immunol, 2023. PMID 37325640, Free PMC Article
  3. Macrophage-derived Osteopontin (SPP1) Protects From Nonalcoholic Steatohepatitis. Han H, et al. Gastroenterology, 2023 Jul. PMID 37028770, Free PMC Article
  4. Bone sialoprotein promotes lung cancer osteolytic bone metastasis via MMP14-dependent mechanisms. Chen WC, et al. Biochem Pharmacol, 2023 May. PMID 37028462
  5. Blocking osteopontin expression attenuates neuroinflammation and mitigates LPS-induced depressive-like behavior in mice. Li T, et al. J Affect Disord, 2023 Jun 1. PMID 36842657

See all (913) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase.
    Title: Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase.
  2. Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury.
    Title: Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury.
  3. Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults.
    Title: Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults.
  4. Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion.
    Title: Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion.
  5. CWC22-Mediated Alternative Splicing of Spp1 Regulates Nociception in Inflammatory Pain.
    Title: CWC22-Mediated Alternative Splicing of Spp1 Regulates Nociception in Inflammatory Pain.
  6. Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
    Title: Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
  7. Osteopontin-driven T-cell accumulation and function in adipose tissue and liver promoted insulin resistance and MAFLD.
    Title: Osteopontin-driven T-cell accumulation and function in adipose tissue and liver promoted insulin resistance and MAFLD.
  8. Increased expression of OPN contributes to idiopathic pulmonary fibrosis and indicates a poor prognosis.
    Title: Increased expression of OPN contributes to idiopathic pulmonary fibrosis and indicates a poor prognosis.
  9. Contributions of increased osteopontin and hypophosphatemia to dentoalveolar defects in osteomalacic Hyp mice.
    Title: Contributions of increased osteopontin and hypophosphatemia to dentoalveolar defects in osteomalacic Hyp mice.
  10. Regulatory roles of Osteopontin in lung epithelial inflammation and epithelial-telocyte interaction.
    Title: Regulatory roles of Osteopontin in lung epithelial inflammation and epithelial-telocyte interaction.
Submit: New GeneRIF Correction See all GeneRIFs (430)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables ion binding ISO
Inferred from Sequence Orthology
more info
  
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in androgen catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within biomineral tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in bone mineralization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to fluid shear stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to testosterone stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within collecting duct development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular phosphate ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of estradiol secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in response to steroid hormone ISO
Inferred from Sequence Orthology
more info
  
involved_in response to vitamin D ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within urate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
osteopontin
Names
44 kDa bone phosphoprotein
bone sialoprotein 1
calcium oxalate crystal growth inhibitor protein
early T-lymphocyte activation 1 protein
minopontin
osteopontin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204201.1 → NP_001191130.1  osteopontin isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC124106
    UniProtKB/TrEMBL
    Q3UBR1, Q3UZY3
    Conserved Domains (1) summary
    pfam00865
    Location:38 → 311
    Osteopontin; Osteopontin

  2. NM_001204202.1 → NP_001191131.1  osteopontin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001191131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC124106, AI882055, AK150845, AK165965
    UniProtKB/TrEMBL
    Q3UBR1, Q3UZY3
    Conserved Domains (1) summary
    pfam00865
    Location:38 → 310
    Osteopontin; Osteopontin

  3. NM_001204203.1 → NP_001191132.1  osteopontin isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124106
    Consensus CDS
    CCDS57367.1
    UniProtKB/TrEMBL
    F8WIP8, Q3UBR1, Q3UZY3
    Related
    ENSMUSP00000084043.7, ENSMUST00000086833.13
    Conserved Domains (1) summary
    pfam00865
    Location:22 → 295
    Osteopontin; Osteopontin

  4. NM_001204233.1 → NP_001191162.1  osteopontin isoform 4 precursor

    See identical proteins and their annotated locations for NP_001191162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses a downstream in-frame start codon and lacks an exon in the coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    AC124106
    Consensus CDS
    CCDS19486.1
    UniProtKB/Swiss-Prot
    P10923, P19008, Q91VH4
    UniProtKB/TrEMBL
    Q3UBR1, Q3UZY3, Q547B5
    Related
    ENSMUSP00000108367.2, ENSMUST00000112747.2
    Conserved Domains (1) summary
    pfam00865
    Location:22 → 294
    Osteopontin; Osteopontin

  5. NM_009263.3 → NP_033289.2  osteopontin isoform 4 precursor

    See identical proteins and their annotated locations for NP_033289.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses a downstream in-frame start codon and lacks an exon in the coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (4), which is shorter than isoform 1.
    Source sequence(s)
    AC124106, AI882055, AK160540
    Consensus CDS
    CCDS19486.1
    UniProtKB/Swiss-Prot
    P10923, P19008, Q91VH4
    UniProtKB/TrEMBL
    Q3UBR1, Q3UZY3, Q547B5
    Related
    ENSMUSP00000031243.9, ENSMUST00000031243.15
    Conserved Domains (1) summary
    pfam00865
    Location:22 → 294
    Osteopontin; Osteopontin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    104582977..104588919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10923.1 GenPept UniProtKB/Swiss-Prot:P10923

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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