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Elfn2 leucine rich repeat and fibronectin type III, extracellular 2 [ Mus musculus (house mouse) ]

Gene ID: 207393, updated on 11-Apr-2024

Summary

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Official Symbol
Elfn2provided by MGI
Official Full Name
leucine rich repeat and fibronectin type III, extracellular 2provided by MGI
Primary source
MGI:MGI:3608416
See related
Ensembl:ENSMUSG00000043460 AllianceGenome:MGI:3608416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrrc62; Ppp1r29; 6330514E13
Summary
Predicted to enable protein phosphatase inhibitor activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in eye; intestine; male reproductive gland or organ; and nervous system. Orthologous to human ELFN2 (extracellular leucine rich repeat and fibronectin type III domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 10.4), testis adult (RPKM 9.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.64 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78551531..78603056, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78667333..78718771, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52187 Neighboring gene predicted gene, 36877 Neighboring gene RIKEN cDNA 1700041B01 gene Neighboring gene predicted gene, 52188 Neighboring gene STARR-positive B cell enhancer ABC_E5495 Neighboring gene MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene caspase recruitment domain family, member 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior. Dunn HA, et al. Mol Psychiatry, 2019 Dec. PMID 31485013, Free PMC Article
  2. The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. Dolan J, et al. BMC Genomics, 2007 Sep 14. PMID 17868438, Free PMC Article
  3. Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors. Cao Y, et al. Proc Natl Acad Sci U S A, 2020 Sep 22. PMID 32879010, Free PMC Article
  4. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
  5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 29
Names
5leucine rich repeat containing 62
extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2
leucine rich repeat containing 62
leucine-rich repeat and fibronectin type-III domain-containing protein 6
leucine-rich repeat-containing protein 62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358692.2 → NP_001345621.1  protein phosphatase 1 regulatory subunit 29 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL591946
    Consensus CDS
    CCDS27621.1
    UniProtKB/Swiss-Prot
    Q68FM6, Q69Z72, Q8CCW8
    Related
    ENSMUSP00000085960.5, ENSMUST00000088592.6
    Conserved Domains (4) summary
    TIGR00864
    Location:157 → 227
    PCC; polycystin cation channel protein
    sd00031
    Location:60 → 80
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:200 → 226
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:80 → 139
    LRR_8; Leucine rich repeat

  2. NM_001416409.1 → NP_001403338.1  protein phosphatase 1 regulatory subunit 29 precursor

    Status: VALIDATED

    Source sequence(s)
    AL591946
    UniProtKB/Swiss-Prot
    Q68FM6, Q69Z72, Q8CCW8

  3. NM_183141.3 → NP_898964.2  protein phosphatase 1 regulatory subunit 29 precursor

    See identical proteins and their annotated locations for NP_898964.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL591946
    Consensus CDS
    CCDS27621.1
    UniProtKB/Swiss-Prot
    Q68FM6, Q69Z72, Q8CCW8
    Related
    ENSMUSP00000155111.2, ENSMUST00000229441.2
    Conserved Domains (4) summary
    TIGR00864
    Location:157 → 227
    PCC; polycystin cation channel protein
    sd00031
    Location:60 → 80
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:200 → 226
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:80 → 139
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78551531..78603056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159292.1 → XP_036015185.1  protein phosphatase 1 regulatory subunit 29 isoform X1

    UniProtKB/Swiss-Prot
    Q68FM6, Q69Z72, Q8CCW8
    Conserved Domains (4) summary
    TIGR00864
    Location:157 → 227
    PCC; polycystin cation channel protein
    sd00031
    Location:60 → 80
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:200 → 226
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:80 → 139
    LRR_8; Leucine rich repeat

  2. XM_036159290.1 → XP_036015183.1  protein phosphatase 1 regulatory subunit 29 isoform X1

    UniProtKB/Swiss-Prot
    Q68FM6, Q69Z72, Q8CCW8
    Conserved Domains (4) summary
    TIGR00864
    Location:157 → 227
    PCC; polycystin cation channel protein
    sd00031
    Location:60 → 80
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:200 → 226
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:80 → 139
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FM6.1 GenPept UniProtKB/Swiss-Prot:Q68FM6

Gene LinkOut

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