Spn sialophorin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spnprovided by MGI
Official Full Name: sialophorinprovided by MGI
Primary source: MGI:MGI:98384
See related: Ensembl:ENSMUSG00000051457 AllianceGenome:MGI:98384
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd43; Ly48; Galgp; Ly-48; A630014B01Rik
Summary: Enables heat shock protein binding activity. Involved in leukocyte tethering or rolling and positive regulation of T cell migration. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; regulation of T cell activation; and regulation of defense response. Located in basement membrane; external side of plasma membrane; and uropod. Is integral component of plasma membrane. Orthologous to human SPN (sialophorin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 26.4), spleen adult (RPKM 15.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.35 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126731404..126743785, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127123637..127145552, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation.
Title: CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation.
CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection.
Title: CD43 sialoglycoprotein modulates cardiac inflammation and murine susceptibility to Trypanosoma cruzi infection.
Data provide evidence for an important role of CD43 in modulating immune dysregulation and mortality following sepsis.
Title: Increased mortality in CD43-deficient mice during sepsis.
glycosylation status of CD43 protein on leukemia cells is associated with sensitivity to CTL-mediated cytolysis
Title: Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis.
findings demonstrate that CD43 is a major E-selectin ligand in Th17 cells that functions independent of P-selectin glycoprotein ligand-1
Title: CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo.
CD43 may be an important mediator of macrophage lipid homeostasis, thereby affecting macrophage foam cell formation and ultimately atherosclerotic plaque development.
Title: Cluster of differentiation 43 deficiency in leukocytes leads to reduced atherosclerosis--brief report.
We have identified a robust physiologic role for CD43 in a relevant animal model and established an important in vivo function for CD43-dependent regulation of IFN-gamma production.
Title: CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice.
Results show that while CD43 binding to ezrin-radixin-moesin proteins is crucial for S76 phosphorylation, CD43 movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism.
Title: CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation.
study found that the M. tuberculosis Cpn60.2 molecular chaperone is the major mycobacterial surface ligand that interacts with CD43 to stabilize the interaction between M. tuberculosis and the macrophage
Title: Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface.
The loss of both PSGL-1 and CD43 led to a further increase in T cell adhesion and proliferation
Title: P-selectin glycoprotein ligand-1 negatively regulates T-cell immune responses.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in T-helper 1 cell lineage commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type IV hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of T cell activation	IEA Inferred from Electronic Annotation more info
involved_in regulation of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to protozoan	IDA Inferred from Direct Assay more info	PubMed
involved_in type II interferon production	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in uropod	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leukosialin

Names: 3E8 antigen; B-cell differentiation antigen LP-3; leukocyte sialoglycoprotein; lymphocyte antigen 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037810.2 → NP_001032899.1 leukosialin precursor

See identical proteins and their annotated locations for NP_001032899.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC122537, AK041712, AK134098

Consensus CDS

CCDS21858.1

UniProtKB/Swiss-Prot

P15702

UniProtKB/TrEMBL

Q544C5

Related

ENSMUSP00000122787.2, ENSMUST00000143713.2

Conserved Domains (1) summary

pfam15782
Location:100 → 246

GREB1; Gene regulated by oestrogen in breast cancer
NM_009259.5 → NP_033285.1 leukosialin precursor

See identical proteins and their annotated locations for NP_033285.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC122537, AK077764, AK134098, AW540100

Consensus CDS

CCDS21858.1

UniProtKB/Swiss-Prot

P15702

UniProtKB/TrEMBL

Q544C5

Related

ENSMUSP00000049534.6, ENSMUST00000049931.6

Conserved Domains (1) summary

pfam15782
Location:100 → 246

GREB1; Gene regulated by oestrogen in breast cancer

RNA

NR_110337.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains 2 novel exons at the 3' end compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC122537, AK041480