Spink4 serine peptidase inhibitor, Kazal type 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spink4provided by MGI
Official Full Name: serine peptidase inhibitor, Kazal type 4provided by MGI
Primary source: MGI:MGI:1341848
See related: Ensembl:ENSMUSG00000028415 AllianceGenome:MGI:1341848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MPGC60
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Is expressed in brain ventricular layer; ganglia; liver lobe; and olfactory epithelium. Orthologous to human SPINK4 (serine peptidase inhibitor Kazal type 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 3974.1), colon adult (RPKM 1771.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 20.64 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (40920056..40931395)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (40920056..40931395)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPINK4 promotes colorectal cancer cell proliferation and inhibits ferroptosis.
Title: SPINK4 promotes colorectal cancer cell proliferation and inhibits ferroptosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Bag1 (e-PCR), detects polymorphism
- UniSTS:141154

NoName (e-PCR)
- UniSTS:492902

D4Mit195 (e-PCR), detects polymorphism
- UniSTS:129976

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease inhibitor Kazal-type 4

Names: peptide PEC-60 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011463.2 → NP_035593.2 serine protease inhibitor Kazal-type 4 precursor

See identical proteins and their annotated locations for NP_035593.2

Status: VALIDATED

Source sequence(s)

BC117050, CF381698

Consensus CDS

CCDS18052.1

UniProtKB/Swiss-Prot

O35679, Q149Z4

Related

ENSMUSP00000030122.5, ENSMUST00000030122.5

Conserved Domains (1) summary

cl00097
Location:42 → 86

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...