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Zbtb7c zinc finger and BTB domain containing 7C [ Mus musculus (house mouse) ]

Gene ID: 207259, updated on 5-Mar-2024

Summary

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Official Symbol
Zbtb7cprovided by MGI
Official Full Name
zinc finger and BTB domain containing 7Cprovided by MGI
Primary source
MGI:MGI:2443302
See related
Ensembl:ENSMUSG00000044646 AllianceGenome:MGI:2443302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kr-pok; Zbtb36; B230208J24Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of fat cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity. Located in nucleus. Is expressed in central nervous system; craniocervical region bone; esophagus; maturing glomerular tuft; and nose. Orthologous to human ZBTB7C (zinc finger and BTB domain containing 7C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 11.5), colon adult (RPKM 6.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb7c in Genome Data Viewer
Location:
18 E3; 18 51.1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (75953249..76281635)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (75820178..76148564)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700034B16 gene Neighboring gene predicted gene, 33703 Neighboring gene STARR-seq mESC enhancer starr_45085 Neighboring gene STARR-seq mESC enhancer starr_45086 Neighboring gene predicted gene, 52362 Neighboring gene RIKEN cDNA 2900057B20 gene Neighboring gene STARR-seq mESC enhancer starr_45090 Neighboring gene predicted gene, 52361 Neighboring gene STARR-seq mESC enhancer starr_45092 Neighboring gene microRNA 6358 Neighboring gene predicted gene, 52360 Neighboring gene predicted gene 9028

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Derepression of matrix metalloproteinase gene transcription and an emphysema-like phenotype in transcription factor Zbtb7c knockout mouse lungs. Jeon BN, et al. FEBS Lett, 2019 Sep. PMID 31222731
  2. Zbtb7c is a critical gluconeogenic transcription factor that induces glucose-6-phosphatase and phosphoenylpyruvate carboxykinase 1 genes expression during mice fasting. Choi WI, et al. Biochim Biophys Acta Gene Regul Mech, 2019 Jun. PMID 30959128
  3. Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity. Choi WI, et al. Exp Mol Med, 2021 May. PMID 34017061, Free PMC Article
  4. Retinoic acid regulation of eye and testis-specific transcripts within a complex locus. Das P, et al. Mech Dev, 2007 Feb. PMID 17166701, Free PMC Article
  5. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. He X, et al. Nature, 2005 Feb 24. PMID 15729333

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity.
    Title: Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity.
  2. Zbtb7c degradation or absence may contribute to the pathogenesis of emphysema
    Title: Derepression of matrix metalloproteinase gene transcription and an emphysema-like phenotype in transcription factor Zbtb7c knockout mouse lungs.
  3. Zbtb7c to be a crucial metabolic regulator of blood glucose homeostasis, during mammalian fasting.
    Title: Zbtb7c is a critical gluconeogenic transcription factor that induces glucose-6-phosphatase and phosphoenylpyruvate carboxykinase 1 genes expression during mice fasting.
  4. findings show that Zbtb7c is a key molecule that recruits an NCoR/Hdac3 complex to inhibit phosphorylation of c-Jun, and thereby repress Mmp gene expression
    Title: Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription.
  5. Kr-pok (kidney cancer-related POZ domain and Kruppel-like protein) activates transcription of the FASN gene.
    Title: Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 7C
Names
zinc finger and BTB domain containing 36
zinc finger and BTB domain-containing protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357506.2 → NP_001344435.1  zinc finger and BTB domain-containing protein 7C

    Status: VALIDATED

    Source sequence(s)
    AC107768
    Consensus CDS
    CCDS29349.1
    UniProtKB/Swiss-Prot
    Q8VCZ7
    Related
    ENSMUSP00000126808.2, ENSMUST00000167921.2
    Conserved Domains (3) summary
    COG5189
    Location:380 → 468
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:394 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18328
    Location:9 → 128
    BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

  2. NM_145356.3 → NP_663331.1  zinc finger and BTB domain-containing protein 7C

    See identical proteins and their annotated locations for NP_663331.1

    Status: VALIDATED

    Source sequence(s)
    BC070424
    Consensus CDS
    CCDS29349.1
    UniProtKB/Swiss-Prot
    Q8VCZ7
    Related
    ENSMUSP00000057856.8, ENSMUST00000058997.15
    Conserved Domains (3) summary
    COG5189
    Location:380 → 468
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:394 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18328
    Location:9 → 128
    BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    75953249..76281635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161041.1 → XP_036016934.1  zinc finger and BTB domain-containing protein 7C isoform X1

    Conserved Domains (3) summary
    COG5189
    Location:386 → 474
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:400 → 420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18328
    Location:15 → 134
    BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

  2. XM_036161042.1 → XP_036016935.1  zinc finger and BTB domain-containing protein 7C isoform X2

    UniProtKB/Swiss-Prot
    Q8VCZ7
    Conserved Domains (3) summary
    COG5189
    Location:380 → 468
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:394 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18328
    Location:9 → 128
    BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCZ7.1 GenPept UniProtKB/Swiss-Prot:Q8VCZ7

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