U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stxbp5l syntaxin binding protein 5-like [ Mus musculus (house mouse) ]

Gene ID: 207227, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Stxbp5lprovided by MGI
Official Full Name
syntaxin binding protein 5-likeprovided by MGI
Primary source
MGI:MGI:2443815
See related
Ensembl:ENSMUSG00000022829 AllianceGenome:MGI:2443815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LLGL4; T2dm1; t2md1; tomosyn-2; 9430094L02; A830015P08Rik
Summary
Enables syntaxin binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within glucose homeostasis and regulation of secretion by cell. Located in plasma membrane. Is active in neuromuscular junction and neuronal dense core vesicle. Is expressed in several structures, including alimentary system; brain; male reproductive gland or organ; spinal cord; and trigeminal nerve. Orthologous to human STXBP5L (syntaxin binding protein 5L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 6.9), frontal lobe adult (RPKM 4.8) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16 26.32 cM; 16 B3
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36927437..37205377, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (37107075..37385015, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40777 Neighboring gene STARR-seq mESC enhancer starr_40778 Neighboring gene STARR-positive B cell enhancer ABC_E8633 Neighboring gene STARR-positive B cell enhancer ABC_E950 Neighboring gene F-box protein 40 Neighboring gene polymerase (DNA directed), theta Neighboring gene STARR-seq mESC enhancer starr_40780 Neighboring gene STARR-seq mESC enhancer starr_40781 Neighboring gene LIM and senescent cell antigen like domains 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40782 Neighboring gene predicted gene, 57640 Neighboring gene STARR-seq mESC enhancer starr_40783 Neighboring gene STARR-positive B cell enhancer ABC_E2461 Neighboring gene general transcription factor II E, polypeptide 1 (alpha subunit) Neighboring gene RAB, member RAS oncogene family-like 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that bidirectional moving tomosyn-1 (Stxbp5) and tomosyn-2 (Stxbp5l) puncta were observed.
    Title: Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.
  2. tomosyn-2 supports motor performance by regulation of transmitter release willingness to sustain synaptic strength during high-frequency transmission, which makes this gene a candidate for involvement in neuromuscular disorders.
    Title: Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.
  3. Data indicate that glucose induces phosphorylation, ubiquitination, and degradation of tomosyn-2.
    Title: Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.
  4. these findings suggest that tomosyn-2 is a key negative regulator of insulin secretion.
    Title: Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Associated conditions

Description Tests
type 2 diabetes mellitus 1
GeneReviews: Not available

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC169507

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of insulin secretion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuromuscular junction EXP
Inferred from Experiment
more info
 PubMed 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal dense core vesicle IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in neuronal dense core vesicle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
syntaxin-binding protein 5-like
Names
insulin level locus 1
lethal(2) giant larvae protein homolog 4
tomosyn 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114611.2 → NP_001108083.1  syntaxin-binding protein 5-like isoform s

    See identical proteins and their annotated locations for NP_001108083.1

    Status: VALIDATED

    Source sequence(s)
    AC113964, AC116468, AC155254
    Consensus CDS
    CCDS49846.1
    UniProtKB/TrEMBL
    B7ZN48
    Related
    ENSMUSP00000110428.2, ENSMUST00000114780.8
    Conserved Domains (5) summary
    COG2319
    Location:108 → 493
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1037 → 1097
    R-SNARE_STXBP5; SNARE domain of STXBP5
    pfam08366
    Location:288 → 395
    LLGL; LLGL2
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001114612.2 → NP_001108084.1  syntaxin-binding protein 5-like isoform b

    See identical proteins and their annotated locations for NP_001108084.1

    Status: VALIDATED

    Source sequence(s)
    AC113964, AC116468, AC155254
    Consensus CDS
    CCDS49847.1
    UniProtKB/TrEMBL
    B2RQE5
    Related
    ENSMUSP00000110430.2, ENSMUST00000114782.8
    Conserved Domains (5) summary
    COG2319
    Location:248 → 551
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1094 → 1154
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:287 → 395
    LLGL; LLGL2
    cl29593
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001114613.2 → NP_001108085.1  syntaxin-binding protein 5-like isoform m

    See identical proteins and their annotated locations for NP_001108085.1

    Status: VALIDATED

    Source sequence(s)
    AC113964, AC116468, AC155254
    Consensus CDS
    CCDS49848.1
    UniProtKB/TrEMBL
    B7ZN48
    Related
    ENSMUSP00000110429.2, ENSMUST00000114781.8
    Conserved Domains (5) summary
    COG2319
    Location:108 → 493
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1061 → 1121
    R-SNARE_STXBP5; SNARE domain of STXBP5
    pfam08366
    Location:288 → 395
    LLGL; LLGL2
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_172440.4 → NP_766028.2  syntaxin-binding protein 5-like isoform xb

    See identical proteins and their annotated locations for NP_766028.2

    Status: VALIDATED

    Source sequence(s)
    AC113964, AC116468, AC155254
    Consensus CDS
    CCDS28159.2
    UniProtKB/Swiss-Prot
    Q3TSM3, Q3UVG2, Q5DQR1, Q5DQR2, Q5DQR3, Q5DQR4, Q8BS52
    UniProtKB/TrEMBL
    B7ZN49
    Related
    ENSMUSP00000110435.2, ENSMUST00000114787.8
    Conserved Domains (5) summary
    COG2319
    Location:108 → 493
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1118 → 1178
    R-SNARE_STXBP5; SNARE domain of STXBP5
    pfam08366
    Location:288 → 395
    LLGL; LLGL2
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    36927437..37205377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159822.1 → XP_036015715.1  syntaxin-binding protein 5-like isoform X5

    UniProtKB/TrEMBL
    B7ZN48
    Conserved Domains (5) summary
    COG2319
    Location:248 → 551
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1068 → 1128
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:287 → 395
    LLGL; LLGL2
    cl29593
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006521886.4 → XP_006521949.1  syntaxin-binding protein 5-like isoform X2

    UniProtKB/TrEMBL
    B7ZN50
    Conserved Domains (5) summary
    COG2319
    Location:248 → 551
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1125 → 1185
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:287 → 395
    LLGL; LLGL2
    cl29593
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_036159821.1 → XP_036015714.1  syntaxin-binding protein 5-like isoform X4

    UniProtKB/TrEMBL
    B7ZN48
    Conserved Domains (5) summary
    COG2319
    Location:248 → 551
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1092 → 1152
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:287 → 395
    LLGL; LLGL2
    cl29593
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_006521884.4 → XP_006521947.1  syntaxin-binding protein 5-like isoform X1

    See identical proteins and their annotated locations for XP_006521947.1

    UniProtKB/TrEMBL
    B7ZN50
    Conserved Domains (5) summary
    COG2319
    Location:248 → 551
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1149 → 1209
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:287 → 395
    LLGL; LLGL2
    cl29593
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_036159824.1 → XP_036015717.1  syntaxin-binding protein 5-like isoform X6

    UniProtKB/TrEMBL
    B7ZN50
    Conserved Domains (4) summary
    COG2319
    Location:9 → 285
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:956 → 1016
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:17 → 54
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:94 → 202
    LLGL; LLGL2

  6. XM_017316899.3 → XP_017172388.1  syntaxin-binding protein 5-like isoform X6

    UniProtKB/TrEMBL
    B7ZN50
    Conserved Domains (4) summary
    COG2319
    Location:9 → 285
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:956 → 1016
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:17 → 54
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:94 → 202
    LLGL; LLGL2

  7. XM_036159823.1 → XP_036015716.1  syntaxin-binding protein 5-like isoform X6

    UniProtKB/TrEMBL
    B7ZN50
    Conserved Domains (4) summary
    COG2319
    Location:9 → 285
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:956 → 1016
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:17 → 54
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:94 → 202
    LLGL; LLGL2

  8. XM_030249014.1 → XP_030104874.1  syntaxin-binding protein 5-like isoform X10

    Conserved Domains (1) summary
    cd15893
    Location:722 → 782
    R-SNARE_STXBP5; SNARE domain of STXBP5

  9. XM_030249013.1 → XP_030104873.1  syntaxin-binding protein 5-like isoform X9

    Conserved Domains (1) summary
    cd15893
    Location:746 → 806
    R-SNARE_STXBP5; SNARE domain of STXBP5

  10. XM_036159827.1 → XP_036015720.1  syntaxin-binding protein 5-like isoform X11

    Conserved Domains (1) summary
    cd15893
    Location:634 → 694
    R-SNARE_STXBP5; SNARE domain of STXBP5

  11. XM_036159826.1 → XP_036015719.1  syntaxin-binding protein 5-like isoform X8

    Conserved Domains (4) summary
    COG2319
    Location:9 → 285
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:901 → 961
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:17 → 54
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:94 → 202
    LLGL; LLGL2

  12. XM_036159825.1 → XP_036015718.1  syntaxin-binding protein 5-like isoform X7

    UniProtKB/TrEMBL
    B7ZN49
    Conserved Domains (4) summary
    COG2319
    Location:9 → 285
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:925 → 985
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:17 → 54
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:94 → 202
    LLGL; LLGL2

  13. XM_030249011.2 → XP_030104871.1  syntaxin-binding protein 5-like isoform X3

    UniProtKB/TrEMBL
    B2RQE5
    Conserved Domains (5) summary
    COG2319
    Location:248 → 551
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1094 → 1154
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:287 → 395
    LLGL; LLGL2
    cl29593
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  14. XM_006521885.5 → XP_006521948.1  syntaxin-binding protein 5-like isoform X1

    See identical proteins and their annotated locations for XP_006521948.1

    UniProtKB/TrEMBL
    B7ZN50
    Conserved Domains (5) summary
    COG2319
    Location:248 → 551
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:1149 → 1209
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:73 → 106
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:287 → 395
    LLGL; LLGL2
    cl29593
    Location:73 → 280
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  15. XM_011245849.3 → XP_011244151.1  syntaxin-binding protein 5-like isoform X6

    UniProtKB/TrEMBL
    B7ZN50
    Conserved Domains (4) summary
    COG2319
    Location:9 → 285
    WD40; WD40 repeat [General function prediction only]
    cd15893
    Location:956 → 1016
    R-SNARE_STXBP5; SNARE domain of STXBP5
    sd00039
    Location:17 → 54
    7WD40; WD40 repeat [structural motif]
    pfam08366
    Location:94 → 202
    LLGL; LLGL2

  16. XM_011245850.2 → XP_011244152.1  syntaxin-binding protein 5-like isoform X9

    Conserved Domains (1) summary
    cd15893
    Location:746 → 806
    R-SNARE_STXBP5; SNARE domain of STXBP5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DQR4.1 GenPept UniProtKB/Swiss-Prot:Q5DQR4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous