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Fbxo40 F-box protein 40 [ Mus musculus (house mouse) ]

Gene ID: 207215, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxo40provided by MGI
Official Full Name
F-box protein 40provided by MGI
Primary source
MGI:MGI:2443753
See related
Ensembl:ENSMUSG00000047746 AllianceGenome:MGI:2443753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1195; 9830003A13Rik
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Acts upstream of or within muscle cell differentiation. Located in cytoplasm. Orthologous to human FBXO40 (F-box protein 40). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 22.5), mammary gland adult (RPKM 3.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Fbxo40 in Genome Data Viewer
Location:
16 B3; 16 26.32 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36783823..36811321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36963461..36990530, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930565N06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:36884785-36885086 Neighboring gene STARR-seq mESC enhancer starr_40776 Neighboring gene golgin B1 Neighboring gene STARR-positive B cell enhancer ABC_E8632 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:36932162-36932315 Neighboring gene STARR-positive B cell enhancer ABC_E7446 Neighboring gene STARR-positive B cell enhancer ABC_E4169 Neighboring gene STARR-seq mESC enhancer starr_40777 Neighboring gene hematopoietic cell specific Lyn substrate 1 Neighboring gene STARR-seq mESC enhancer starr_40778 Neighboring gene STARR-positive B cell enhancer ABC_E8633 Neighboring gene STARR-positive B cell enhancer ABC_E950 Neighboring gene polymerase (DNA directed), theta Neighboring gene syntaxin binding protein 5-like Neighboring gene STARR-seq mESC enhancer starr_40780 Neighboring gene STARR-seq mESC enhancer starr_40781 Neighboring gene LIM and senescent cell antigen like domains 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy. Ye J, et al. Gene, 2007 Dec 1. PMID 17928169
  2. The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling. Shi J, et al. Dev Cell, 2011 Nov 15. PMID 22033112
  3. The chromatin regulator Brpf1 regulates embryo development and cell proliferation. You L, et al. J Biol Chem, 2015 May 1. PMID 25773539, Free PMC Article
  4. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Fbxo40 is muscle specific in expression and is upregulated during differentiation.
    Title: The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.
  2. FBXO40 may function as a regulator involved in the postnatal myogenesis.
    Title: FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1195, MGC130416, MGC130417

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in muscle cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
F-box only protein 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037321.2 → NP_001032398.1  F-box only protein 40

    See identical proteins and their annotated locations for NP_001032398.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154763
    Consensus CDS
    CCDS37337.1
    UniProtKB/Swiss-Prot
    P62932
    UniProtKB/TrEMBL
    Q3KN92, Q5DTZ7
    Related
    ENSMUSP00000110454.2, ENSMUST00000114806.2
    Conserved Domains (2) summary
    pfam15965
    Location:12 → 104
    zf-TRAF_2; TRAF-like zinc-finger
    pfam15966
    Location:575 → 683
    F-box_4

  2. NM_001358217.1 → NP_001345146.1  F-box only protein 40

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154763
    Consensus CDS
    CCDS37337.1
    UniProtKB/Swiss-Prot
    P62932
    UniProtKB/TrEMBL
    Q3KN92, Q5DTZ7
    Related
    ENSMUSP00000075266.7, ENSMUST00000075869.13
    Conserved Domains (2) summary
    pfam15965
    Location:12 → 104
    zf-TRAF_2; TRAF-like zinc-finger
    pfam15966
    Location:575 → 683
    F-box_4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    36783823..36811321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521883.5 → XP_006521946.1  F-box only protein 40 isoform X2

    UniProtKB/TrEMBL
    Q5DTZ7
    Conserved Domains (2) summary
    pfam15965
    Location:1 → 57
    zf-TRAF_2; TRAF-like zinc-finger
    pfam15966
    Location:528 → 636
    F-box_4

  2. XM_006521882.4 → XP_006521945.1  F-box only protein 40 isoform X1

    See identical proteins and their annotated locations for XP_006521945.1

    UniProtKB/Swiss-Prot
    P62932
    UniProtKB/TrEMBL
    Q3KN92, Q5DTZ7
    Conserved Domains (2) summary
    pfam15965
    Location:12 → 104
    zf-TRAF_2; TRAF-like zinc-finger
    pfam15966
    Location:575 → 683
    F-box_4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62932.1 GenPept UniProtKB/Swiss-Prot:P62932

Gene LinkOut

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