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Sparc secreted acidic cysteine rich glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 20692, updated on 23-Mar-2024

Summary

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Official Symbol
Sparcprovided by MGI
Official Full Name
secreted acidic cysteine rich glycoproteinprovided by MGI
Primary source
MGI:MGI:98373
See related
Ensembl:ENSMUSG00000018593 AllianceGenome:MGI:98373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ON; BM-40
Summary
Enables calcium ion binding activity and extracellular matrix binding activity. Acts upstream of or within several processes, including bone development; cellular response to growth factor stimulus; and pigmentation. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 1043.9), bladder adult (RPKM 893.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Sparc in Genome Data Viewer
Location:
11 B1.3; 11 33.04 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55284985..55310906, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55394159..55420080, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene FAT atypical cadherin 2 Neighboring gene STARR-seq mESC enhancer starr_29533 Neighboring gene predicted gene, 31842 Neighboring gene STARR-seq mESC enhancer starr_29535 Neighboring gene STARR-seq mESC enhancer starr_29537 Neighboring gene STARR-seq mESC enhancer starr_29542 Neighboring gene STARR-seq mESC enhancer starr_29544 Neighboring gene antioxidant 1 copper chaperone Neighboring gene predicted gene 12235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Matricellular Protein SPARC Decreases in the Lacrimal Gland At Adulthood and During Inflammation. Feldt J, et al. Invest Ophthalmol Vis Sci, 2022 Dec 1. PMID 36479944, Free PMC Article
  2. Growth hormone/IGF-I-dependent signaling restores decreased expression of the myokine SPARC in aged skeletal muscle. Mathes S, et al. J Mol Med (Berl), 2022 Nov. PMID 36178526, Free PMC Article
  3. SPARC coordinates extracellular matrix remodeling and efficient recruitment to and migration of antigen-specific T cells in the brain following infection. McGovern KE, et al. Sci Rep, 2021 Feb 25. PMID 33633185, Free PMC Article
  4. SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload. Riley HJ, et al. Am J Physiol Heart Circ Physiol, 2021 Feb 1. PMID 33306449, Free PMC Article
  5. Secreted protein acidic and rich in cysteine (SPARC) knockout mice have greater outflow facility. Yu L, et al. PLoS One, 2020. PMID 33147244, Free PMC Article

See all (310) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
    Title: The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
  2. Effect of Sparc knockout on the extracellular matrix of mouse periodontal ligament cells.
    Title: Effect of Sparc knockout on the extracellular matrix of mouse periodontal ligament cells.
  3. Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients.
    Title: Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients.
  4. Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity.
    Title: Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity.
  5. The Matricellular Protein SPARC Decreases in the Lacrimal Gland At Adulthood and During Inflammation.
    Title: The Matricellular Protein SPARC Decreases in the Lacrimal Gland At Adulthood and During Inflammation.
  6. Growth hormone/IGF-I-dependent signaling restores decreased expression of the myokine SPARC in aged skeletal muscle.
    Title: Growth hormone/IGF-I-dependent signaling restores decreased expression of the myokine SPARC in aged skeletal muscle.
  7. Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells.
    Title: Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells.
  8. SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension.
    Title: SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension.
  9. SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
    Title: SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
  10. Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer.
    Title: Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (133)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables extracellular matrix binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lung development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
  
located_in platelet alpha granule membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SPARC
Names
basement-membrane protein 40
osteonectin
secreted protein acidic and rich in cysteine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290817.1 → NP_001277746.1  SPARC isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AA798908, AK148670, AK161229, BB857564, BE655213, BY781653, CJ132527
    Consensus CDS
    CCDS70189.1
    UniProtKB/TrEMBL
    Q3TXI6, Q5NCU4
    Related
    ENSMUSP00000104486.2, ENSMUST00000108858.8
    Conserved Domains (2) summary
    cd01328
    Location:69 → 150
    FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
    cd16235
    Location:153 → 292
    EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)

  2. NM_009242.5 → NP_033268.1  SPARC precursor

    See identical proteins and their annotated locations for NP_033268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA798908, AK161229, BB857564, BE655213, BY781653, CJ132527
    Consensus CDS
    CCDS24712.1
    UniProtKB/Swiss-Prot
    P07214
    UniProtKB/TrEMBL
    Q3TXI6, Q5NCU5
    Related
    ENSMUSP00000018737.7, ENSMUST00000018737.13
    Conserved Domains (2) summary
    cd01328
    Location:70 → 151
    FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...
    cd16235
    Location:154 → 293
    EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    55284985..55310906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07214.1 GenPept UniProtKB/Swiss-Prot:P07214

Gene LinkOut

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