Sox7 SRY (sex determining region Y)-box 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sox7provided by MGI
Official Full Name: SRY (sex determining region Y)-box 7provided by MGI
Primary source: MGI:MGI:98369
See related: Ensembl:ENSMUSG00000063060 AllianceGenome:MGI:98369
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Acts upstream of or within positive regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; reproductive system; and urinary system. Used to study congenital diaphragmatic hernia. Orthologous to human SOX7 (SRY-box transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 22.4), heart adult (RPKM 6.0) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 33.34 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (64181155..64188181)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (63943706..63950732)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction.
Title: Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction.
SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2.
Title: SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2.
The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner.
Title: The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner.
Dll4 Blockade Promotes Angiogenesis in Nonhealing Wounds of Sox7-Deficient Mice.
Title: Dll4 Blockade Promotes Angiogenesis in Nonhealing Wounds of Sox7-Deficient Mice.
The first genome-wide analysis of Sox7 function.
Title: Sox7 Regulates Lineage Decisions in Cardiovascular Progenitor Cells.
Sox7 mediates HLA I antibody-dependent endothelial cell activation and acute kidney allograft rejection via the Jagged1-Notch1 pathway.
Title: Sox7 is involved in antibody-dependent endothelial cell activation and renal allograft injury via the Jagged1-Notch1 pathway.
Data show that SOX7, SOX17 and SOX18 (SOXF) transcriptional factors are induced during satellite cell specification.
Title: SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity.
Sox7 promotes tumor growth via vessel abnormalization, and its level determines the therapeutic outcome of VEGFR2 inhibition in High-grade glioma.
Title: Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality.
SOX7 is dispensable for myogenesis but is necessary to promote satellite cell development and survival.
Title: SOX7 Is Required for Muscle Satellite Cell Development and Maintenance.
By E10.5, both Sox7 complete knockout and FLK1-specific deletion of Sox7 lead to widespread vascular defects. In contrast, while SOX7 is expressed in the earliest specified blood progenitors, the VAV-specific deletion of Sox7 does not affect the hematopoietic system. Together, our data reveal the unique role of SOX7 in vasculogenesis and angiogenesis during embryonic development.
Title: SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (5) 1 citation

General gene information

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Markers

RH131053 (e-PCR)
- UniSTS:214336

Sox7 (e-PCR), detects polymorphism
- UniSTS:471107

Sox7 (e-PCR), detects polymorphism
- UniSTS:144492

Sox7 (e-PCR), detects polymorphism
- UniSTS:536550

PMC60197P1 (e-PCR)
- UniSTS:273397

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoderm formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor SOX-7

Names: SRY-box containing gene 7; mSOX7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011446.1 → NP_035576.1 transcription factor SOX-7

See identical proteins and their annotated locations for NP_035576.1

Status: PROVISIONAL

Source sequence(s)

AB023419

Consensus CDS

CCDS27206.1

UniProtKB/Swiss-Prot

P40646, Q9R1T6

UniProtKB/TrEMBL

Q3U0W9, Q3U1W5

Related

ENSMUSP00000078597.6, ENSMUST00000079652.7

Conserved Domains (2) summary

cd01388
Location:44 → 115

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam12067
Location:175 → 378

Sox_C_TAD; Sox C-terminal transactivation domain