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Snrpc U1 small nuclear ribonucleoprotein C [ Mus musculus (house mouse) ]

Gene ID: 20630, updated on 5-Mar-2024

Summary

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Official Symbol
Snrpcprovided by MGI
Official Full Name
U1 small nuclear ribonucleoprotein Cprovided by MGI
Primary source
MGI:MGI:109489
See related
Ensembl:ENSMUSG00000024217 AllianceGenome:MGI:109489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U1C; U1-C; Snrp1c
Summary
Predicted to enable several functions, including RNA binding activity; U1 snRNP binding activity; and protein homodimerization activity. Predicted to be involved in mRNA 5'-splice site recognition and spliceosomal snRNP assembly. Predicted to be located in Cajal body. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease; mixed connective tissue disease; and systemic lupus erythematosus. Orthologous to human SNRPC (small nuclear ribonucleoprotein polypeptide C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 61.0), duodenum adult (RPKM 57.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 14.59 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28059002..28070942)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27840028..27851968)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene SAM pointed domain containing ets transcription factor Neighboring gene inflammation and lipid regulator with UBA-like and NBR1-like domains Neighboring gene STARR-seq mESC enhancer starr_42174 Neighboring gene ribosomal protein S2, pseudogene 9 Neighboring gene STARR-positive B cell enhancer ABC_E2475 Neighboring gene STARR-positive B cell enhancer ABC_E4198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27976840-27977098 Neighboring gene bridge-like lipid transfer protein family member 3A Neighboring gene STARR-positive B cell enhancer ABC_E7504 Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene ankyrin repeat and SAM domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and developmental expression of a small ribonuclear protein in the mouse testis. Morales CR, et al. Mol Reprod Dev, 1997 Apr. PMID 9094092
  2. RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment. Huang SC, et al. Mol Cell Biol, 2012 Jan. PMID 22083953, Free PMC Article
  3. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Sun S, et al. Nat Commun, 2015 Jan 27. PMID 25625564, Free PMC Article
  4. Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C. Nelissen RL, et al. Gene, 1997 Jan 15. PMID 9031639
  5. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Bedford MT, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724750, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U1 snRNP binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA 5'-splice site binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA 5'-splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U1 small nuclear ribonucleoprotein C
Names
U1 small nuclear ribonucleoprotein 1C
U1 snRNP C
U1 snRNP protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413574.1 → NP_001400503.1  U1 small nuclear ribonucleoprotein C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126040
    UniProtKB/TrEMBL
    A0A3B2WCR6
    Related
    ENSMUSP00000156644.2, ENSMUST00000233657.2

  2. NM_001413575.1 → NP_001400504.1  U1 small nuclear ribonucleoprotein C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126040
    UniProtKB/TrEMBL
    A0A3B2W450

  3. NM_001413576.1 → NP_001400505.1  U1 small nuclear ribonucleoprotein C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126040
    UniProtKB/TrEMBL
    A0A3B2W450
    Related
    ENSMUSP00000156747.2, ENSMUST00000233752.2

  4. NM_001413577.1 → NP_001400506.1  U1 small nuclear ribonucleoprotein C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126040

  5. NM_011432.3 → NP_035562.1  U1 small nuclear ribonucleoprotein C isoform 1

    See identical proteins and their annotated locations for NP_035562.1

    Status: VALIDATED

    Source sequence(s)
    AC126040
    Consensus CDS
    CCDS28570.1
    UniProtKB/Swiss-Prot
    Q62241
    UniProtKB/TrEMBL
    Q569X3
    Related
    ENSMUSP00000063976.8, ENSMUST00000071006.9
    Conserved Domains (1) summary
    pfam06220
    Location:1 → 38
    zf-U1; U1 zinc finger

RNA

  1. NR_182164.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126040

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28059002..28070942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249614.1 → XP_030105474.1  U1 small nuclear ribonucleoprotein C isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62241.1 GenPept UniProtKB/Swiss-Prot:Q62241

Gene LinkOut

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