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Snrk SNF related kinase [ Mus musculus (house mouse) ]

Gene ID: 20623, updated on 21-Apr-2024

Summary

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Official Symbol
Snrkprovided by MGI
Official Full Name
SNF related kinaseprovided by MGI
Primary source
MGI:MGI:108104
See related
Ensembl:ENSMUSG00000038145 AllianceGenome:MGI:108104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0096; E030034B15; 2010012F07Rik
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; gut; heart and pericardium; hemolymphoid system; and retina. Orthologous to human SNRK (SNF related kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 60.4), lung adult (RPKM 41.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F4; 9 72.89 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121946332..121998768)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122117266..122169702)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39463 Neighboring gene predicted gene, 39465 Neighboring gene predicted gene, 39464 Neighboring gene STARR-seq mESC enhancer starr_25542 Neighboring gene STARR-seq mESC enhancer starr_25543 Neighboring gene predicted gene, 57550 Neighboring gene anoctamin 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:122142092-122142320 Neighboring gene STARR-seq mESC enhancer starr_25545 Neighboring gene STARR-positive B cell enhancer ABC_E574 Neighboring gene microRNA 8106 Neighboring gene predicted gene, 26797

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart. Thirugnanam K, et al. J Am Heart Assoc, 2019 Nov 19. PMID 31718444, Free PMC Article
  2. Dysregulation of PP2A-Akt interaction contributes to Sucrose non-fermenting related kinase (SNRK) deficiency induced insulin resistance in adipose tissue. Li J, et al. Mol Metab, 2019 Oct. PMID 31420304, Free PMC Article
  3. SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo. Lu Q, et al. Arterioscler Thromb Vasc Biol, 2018 Feb. PMID 29242271, Free PMC Article
  4. Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation. Li Y, et al. Diabetes, 2013 Jul. PMID 23520131, Free PMC Article
  5. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Kertesz N, et al. Gene, 2002 Jul 10. PMID 12234663

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.
    Title: DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.
  2. Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart.
    Title: Cardiomyocyte-Specific Snrk Prevents Inflammation in the Heart.
  3. The SNRK regulates insulin signaling through controlling PPP2R5D phosphorylation, which subsequently impacts PP2A activity and then AKT phosphorylation in both WAT and BAT. SNRK may represent a promising potential target for treating insulin resistance-related metabolic disorders.
    Title: Dysregulation of PP2A-Akt interaction contributes to Sucrose non-fermenting related kinase (SNRK) deficiency induced insulin resistance in adipose tissue.
  4. Endothelial cell SNRK/SP1-ITGB1 signaling axis promotes angiogenesis in vivo.
    Title: SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo.
  5. Using SNRK transgenic and KO mouse models, study found that SNRK decreases cardiac metabolic substrate usage and mitochondrial coupling, while protecting against ischaemia/reperfusion injury. Effects on substrate usage and cell death are dependent on UCP3, which is downregulated through suppression of PPARalpha by Trib3, a novel binding partner of SNRK.
    Title: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.
  6. SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
    Title: Sucrose Nonfermenting-Related Kinase Enzyme-Mediated Rho-Associated Kinase Signaling is Responsible for Cardiac Function.
  7. SNRK may act as a suppressor of adipocyte inflammation and its presence is necessary for maintaining normal adipocyte function.
    Title: Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28970

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SNF-related serine/threonine-protein kinase
Names
SNF1-related kinase
NP_001158044.1
NP_001344703.1
NP_001344704.1
NP_001344705.1
NP_598502.2
XP_006512062.1
XP_006512063.1
XP_006512065.1
XP_036010647.1
XP_036010648.1
XP_036010649.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164572.1 → NP_001158044.1  SNF-related serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001158044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AC120394, AI842097, BC150742, CJ079755
    Consensus CDS
    CCDS23644.1
    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Related
    ENSMUSP00000112919.2, ENSMUST00000120173.9
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  2. NM_001357774.1 → NP_001344703.1  SNF-related serine/threonine-protein kinase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AC120394, AK082185
    Consensus CDS
    CCDS23644.1
    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  3. NM_001357775.1 → NP_001344704.1  SNF-related serine/threonine-protein kinase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AC120394
    Consensus CDS
    CCDS23644.1
    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  4. NM_001357776.1 → NP_001344705.1  SNF-related serine/threonine-protein kinase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AC120394
    Consensus CDS
    CCDS23644.1
    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  5. NM_133741.2 → NP_598502.2  SNF-related serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_598502.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
    Source sequence(s)
    AC120394, AI842097, BC150742, CJ079755
    Consensus CDS
    CCDS23644.1
    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Related
    ENSMUSP00000114132.2, ENSMUST00000118886.9
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121946332..121998768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512000.5 → XP_006512063.1  SNF-related serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006512063.1

    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  2. XM_006512002.4 → XP_006512065.1  SNF-related serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006512065.1

    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  3. XM_006511999.5 → XP_006512062.1  SNF-related serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006512062.1

    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  4. XM_036154754.1 → XP_036010647.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  5. XM_036154755.1 → XP_036010648.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  6. XM_036154756.1 → XP_036010649.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q8VDU5, Q91WX6
    UniProtKB/TrEMBL
    B9EK90
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDU5.1 GenPept UniProtKB/Swiss-Prot:Q8VDU5

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