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Plk2 polo like kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 20620, updated on 9-Dec-2024

Summary

Official Symbol
Plk2provided by MGI
Official Full Name
polo like kinase 2provided by MGI
Primary source
MGI:MGI:1099790
See related
Ensembl:ENSMUSG00000021701 AllianceGenome:MGI:1099790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Snk
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process in bone marrow cell; negative regulation of cellular senescence; and positive regulation of cell migration involved in sprouting angiogenesis. Acts upstream of or within mitotic cell cycle. Located in chromatin. Is expressed in several structures, including alimentary system; hindlimb interdigital region; integumental system; nervous system; and skeleton. Orthologous to human PLK2 (polo like kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E18 (RPKM 28.3), cortex adult (RPKM 24.4) and 22 other tissues See more
Orthologs
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Genomic context

See Plk2 in Genome Data Viewer
Location:
13 61.97 cM; 13 D2.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (110531578..110537378)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (110395044..110400844)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr13:111158859-111159160 Neighboring gene predicted gene, 41058 Neighboring gene STARR-positive B cell enhancer mm9_chr13:111172985-111173286 Neighboring gene Grb2-binding adaptor, transmembrane Neighboring gene STARR-seq mESC enhancer starr_35639 Neighboring gene STARR-seq mESC enhancer starr_35640 Neighboring gene STARR-positive B cell enhancer mm9_chr13:111352690-111352991 Neighboring gene predicted gene, 32990 Neighboring gene STARR-positive B cell enhancer mm9_chr13:111399586-111399887 Neighboring gene STARR-seq mESC enhancer starr_35641 Neighboring gene predicted gene, 33045

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables ATP-dependent protein binding  
enables ATP-dependent protein binding  
enables ATPase binding  
enables GTPase binding  
enables clathrin heavy chain binding  
enables protein kinase binding  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables protein-containing complex binding  
Items 1 - 25 of 40
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle  
involved_in G1/S transition of mitotic cell cycle  
involved_in G1/S transition of mitotic cell cycle  
involved_in Rap protein signal transduction  
involved_in Rap protein signal transduction  
involved_in Ras protein signal transduction  
involved_in Ras protein signal transduction  
involved_in long-term synaptic depression  
involved_in long-term synaptic depression  
involved_in long-term synaptic potentiation  
involved_in long-term synaptic potentiation  
involved_in memory PubMed 
acts_upstream_of_or_within mitotic cell cycle PubMed 
involved_in mitotic spindle organization  
involved_in mitotic spindle organization PubMed 
involved_in mitotic spindle organization  
involved_in mitotic spindle organization  
involved_in negative regulation of angiogenesis PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of apoptotic process in bone marrow cell PubMed 
involved_in negative regulation of cellular senescence PubMed 
involved_in negative regulation of dendritic spine development  
involved_in negative regulation of excitatory postsynaptic potential  
involved_in negative regulation of protein localization to cell surface  
involved_in peptidyl-serine phosphorylation  
involved_in positive regulation of autophagy  
involved_in positive regulation of autophagy  
involved_in positive regulation of cell migration involved in sprouting angiogenesis PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
involved_in positive regulation of protein catabolic process  
involved_in positive regulation of protein catabolic process  
involved_in positive regulation of receptor internalization  
involved_in protein phosphorylation PubMed 
involved_in protein phosphorylation  
involved_in regulation of centriole replication  
involved_in regulation of centriole replication  
involved_in regulation of synaptic plasticity  
involved_in regulation of synaptic plasticity PubMed 
involved_in regulation of synaptic plasticity  
Items 1 - 25 of 40
Component Evidence Code Pubs
is_active_in centriole  
located_in centriole  
located_in centriole  
is_active_in centrosome  
located_in centrosome  
located_in centrosome  
located_in chromatin PubMed 
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in dendrite  
located_in dendrite  
is_active_in kinetochore  
located_in nucleoplasm  
is_active_in nucleus  
is_active_in spindle pole  

General protein information

Preferred Names
serine/threonine-protein kinase PLK2
Names
PLK-2
serine/threonine-protein kinase SNK
serum-inducible kinase
NP_690017.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152804.2NP_690017.2  serine/threonine-protein kinase PLK2

    See identical proteins and their annotated locations for NP_690017.2

    Status: VALIDATED

    Source sequence(s)
    AK160441, AK164365, BM947259, BP765662, CJ063842
    Consensus CDS
    CCDS26767.1
    UniProtKB/Swiss-Prot
    P53351
    UniProtKB/TrEMBL
    Q548A9, Q8K226
    Related
    ENSMUSP00000022212.8, ENSMUST00000022212.9
    Conserved Domains (4) summary
    smart00220
    Location:79331
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:598679
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:500585
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14188
    Location:77331
    STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    110531578..110537378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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