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Sstr5 somatostatin receptor 5 [ Mus musculus (house mouse) ]

Gene ID: 20609, updated on 11-Apr-2024

Summary

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Official Symbol
Sstr5provided by MGI
Official Full Name
somatostatin receptor 5provided by MGI
Primary source
MGI:MGI:894282
See related
Ensembl:ENSMUSG00000050824 AllianceGenome:MGI:894282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sst5; Smstr5
Summary
Predicted to enable neuropeptide binding activity and somatostatin receptor activity. Acts upstream of or within glucose homeostasis and regulation of insulin secretion. Located in plasma membrane. Human ortholog(s) of this gene implicated in bipolar disorder. Orthologous to human SSTR5 (somatostatin receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Sstr5 in Genome Data Viewer
Location:
17 A3.3; 17 12.62 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25708849..25716262, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25489875..25497288, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, T type, alpha 1H subunit Neighboring gene predicted gene, 33617 Neighboring gene STARR-seq mESC enhancer starr_42107 Neighboring gene tektin 4 Neighboring gene predicted gene, 53993 Neighboring gene predicted gene, 33727 Neighboring gene predicted gene, 33801

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5. Farb TB, et al. Endocrinology, 2017 Nov 1. PMID 28938487
  2. Identification and characterization of new functional truncated variants of somatostatin receptor subtype 5 in rodents. Córdoba-Chacón J, et al. Cell Mol Life Sci, 2010 Apr. PMID 20063038
  3. Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas. Patel SG, et al. World J Surg, 2009 Apr. PMID 19137362
  4. The effect of global SSTR5 gene ablation on the endocrine pancreas and glucose regulation in aging mice. Wang XP, et al. J Surg Res, 2005 Nov. PMID 16026801
  5. Deficiency of somatostatin (SST) receptor type 5 (SSTR5) is associated with sexually dimorphic changes in the expression of SST and SST receptors in brain and pancreas. Ramírez JL, et al. Mol Cell Endocrinol, 2004 Jun 30. PMID 15223137

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRPV1(+) sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling.
    Title: TRPV1(+) sensory nerves modulate corneal inflammation after epithelial abrasion via RAMP1 and SSTR5 signaling.
  2. Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro.
    Title: Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro.
  3. Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner.
    Title: Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner.
  4. Filamin A is required for somatostatin receptor type 5 expression and pasireotide-mediated signaling in pituitary corticotroph tumor cells.
    Title: Filamin A is required for somatostatin receptor type 5 expression and pasireotide-mediated signaling in pituitary corticotroph tumor cells.
  5. rare enteroendocrine cell type in jejunum acts in a paracrine manner to regulate GLP-1 secretion through SSTR5
    Title: UTS2B Defines a Novel Enteroendocrine Cell Population and Regulates GLP-1 Secretion Through SSTR5 in Male Mice.
  6. The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported.
    Title: Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.
  7. mouse somatostatin receptor 5 is sorted by a network of PDZ-domain containing proteins
    Title: Subcellular sorting of the G-protein coupled mouse somatostatin receptor 5 by a network of PDZ-domain containing proteins.
  8. Findings suggest that somatostatin and its receptors (SSTR2 and SSTR5) are important markers in the regulation and development of Sertoli cell.
    Title: Somatostatin and its receptors: functional regulation in the development of mice Sertoli cells.
  9. In comparison to wt, ApoD(-/-) mice exhibit increased SSTR5-like immunoreactivity in paraventricular nuclei and decreased receptor expression in ventromedial hypothalamus and arcuate nucleus.
    Title: Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain.
  10. Somatostatin inhibited GIP and glucagon-like peptide-1 (GLP-1) secretion from primary small intestinal cultures, in part through SSTR5.
    Title: Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables somatostatin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables somatostatin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucocorticoid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
somatostatin receptor type 5
Names
SS-5-R
SS5-R
SS5R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191008.1 → NP_001177937.1  somatostatin receptor type 5

    See identical proteins and their annotated locations for NP_001177937.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131323, AK133767
    Consensus CDS
    CCDS28520.1
    UniProtKB/Swiss-Prot
    A6H6N8, O08858, O08998, Q3UZM7
    UniProtKB/TrEMBL
    Q9JK40
    Related
    ENSMUSP00000128787.3, ENSMUST00000165183.11
    Conserved Domains (2) summary
    pfam00001
    Location:54 → 303
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:48 → 227
    7tm_4; Olfactory receptor

  2. NM_011425.3 → NP_035555.1  somatostatin receptor type 5

    See identical proteins and their annotated locations for NP_035555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131323, AK133609
    Consensus CDS
    CCDS28520.1
    UniProtKB/Swiss-Prot
    A6H6N8, O08858, O08998, Q3UZM7
    UniProtKB/TrEMBL
    Q9JK40
    Related
    ENSMUSP00000051085.5, ENSMUST00000051864.6
    Conserved Domains (2) summary
    pfam00001
    Location:54 → 303
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:48 → 227
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25708849..25716262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08858.3 GenPept UniProtKB/Swiss-Prot:O08858

Gene LinkOut

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