Sstr4 somatostatin receptor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sstr4provided by MGI
Official Full Name: somatostatin receptor 4provided by MGI
Primary source: MGI:MGI:105372
See related: Ensembl:ENSMUSG00000037014 AllianceGenome:MGI:105372
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sst4; Smstr4
Summary: Predicted to enable neuropeptide binding activity and somatostatin receptor activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; positive regulation of arachidonic acid secretion; and regulation of signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; eye; genitourinary system; gut; and respiratory system. Orthologous to human SSTR4 (somatostatin receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 73.44 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148237297..148238684)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148395377..148396764)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reassessment of SST4 Somatostatin Receptor Expression Using SST4-eGFP Knockin Mice and the Novel Rabbit Monoclonal Anti-Human SST4 Antibody 7H49L61.
Title: Reassessment of SST4 Somatostatin Receptor Expression Using SST4-eGFP Knockin Mice and the Novel Rabbit Monoclonal Anti-Human SST4 Antibody 7H49L61.
Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains.
Title: Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains.
SSTR4 regulates mRNA expression of neprilysin, insulin degrading enzyme, and catalase to promote amyloid beta-peptide degradation and phagocytosis in mice.
Title: Somatostatin Receptor Subtype-4 Regulates mRNA Expression of Amyloid-Beta Degrading Enzymes and Microglia Mediators of Phagocytosis in Brains of 3xTg-AD Mice.
Both hippocampal sst2 and sst4 receptors selectively inhibit stress-induced HPA axis activation but mediate anxiolytic and antidepressive effects through distinct mechanisms.
Title: Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality.
Study provides first evidence that somatostatin 4 receptor activation is involved in the behavioral and neuroendocrine alterations induced by chronic stress with a crucial role of plastic changes in the amygdala.
Title: Higher susceptibility of somatostatin 4 receptor gene-deleted mice to chronic stress-induced behavioral and neuroendocrine alterations.
The results of this study revealed that sst4 mediates anxiolytic and antidepressant-like effects by enhancing the stress-responsiveness of several brain regions with special emphasis on the amygdala.
Title: Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models.
The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported.
Title: Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.
SSTR4 and delta-Opioid receptor (dOR) exist in a heteromeric complex and function in synergistic manner.
Title: δ-opioid receptor and somatostatin receptor-4 heterodimerization: possible implications in modulation of pain associated signaling.
SSTR4-like immunoreactivity increases in ApoD(-/) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle.
Title: Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain.
SSTR4 ablation has an effect on inflammatory peptide and receptor expression in the non-inflamed and inflamed murine intestine
Title: Effect of genetic SSTR4 ablation on inflammatory peptide and receptor expression in the non-inflamed and inflamed murine intestine.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Smstr4 (e-PCR), detects polymorphism
- UniSTS:144462

Smstr4 (e-PCR), detects polymorphism
- UniSTS:144463

Smstr4 (e-PCR), detects polymorphism
- UniSTS:144464

NoName (e-PCR)
- UniSTS:484991

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables somatostatin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables somatostatin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucocorticoid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: somatostatin receptor type 4

Names: SS-4-R; SS4-R; SS4R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009219.3 → NP_033245.2 somatostatin receptor type 4

See identical proteins and their annotated locations for NP_033245.2

Status: PROVISIONAL

Source sequence(s)

AK051189, CB522494

Consensus CDS

CCDS38260.1

UniProtKB/Swiss-Prot

P49660, Q8BQ97

UniProtKB/TrEMBL

A0A0R4J1D6

Related

ENSMUSP00000105588.3, ENSMUST00000109962.4

Conserved Domains (1) summary

cd15973
Location:45 → 319

7tmA_SSTR4; somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors