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Sstr1 somatostatin receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 20605, updated on 11-Apr-2024

Summary

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Official Symbol
Sstr1provided by MGI
Official Full Name
somatostatin receptor 1provided by MGI
Primary source
MGI:MGI:98327
See related
Ensembl:ENSMUSG00000035431 AllianceGenome:MGI:98327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SS1R; sst1; SS1-R; SRIF-2; SS-1-R; Smstr1; Smstr-1
Summary
Enables somatostatin receptor activity. Acts upstream of or within cellular response to leukemia inhibitory factor; glutamate receptor signaling pathway; and neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; eye; genitourinary system; gut; and respiratory system. Orthologous to human SSTR1 (somatostatin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 12.3), CNS E18 (RPKM 7.4) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Sstr1 in Genome Data Viewer
Location:
12 C1; 12 25.61 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (58258524..58262822)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (58211421..58216037)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 6 Neighboring gene STARR-seq mESC enhancer starr_32227 Neighboring gene cDNA sequence BC042761 Neighboring gene STARR-seq mESC enhancer starr_32229 Neighboring gene predicted gene, 46329 Neighboring gene STARR-seq mESC enhancer starr_32231 Neighboring gene C-type lectin domain family 14, member a Neighboring gene predicted gene, 30687 Neighboring gene predicted gene, 40428

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Central somatostatin receptor 1 activation reverses acute stress-related alterations of gastric and colonic motor function in mice. Stengel A, et al. Neurogastroenterol Motil, 2011 Jun. PMID 21564422, Free PMC Article
  2. Functional effects of somatostatin receptor 1 activation on synaptic transmission in the mouse hippocampus. Cammalleri M, et al. J Neurochem, 2009 Dec. PMID 19811607
  3. N-type Ca(2+) -channels in murine pancreatic beta-cells are inhibited by an exclusive coupling with somatostatin receptor subtype 1. Smith PA. Endocrinology, 2009 Feb. PMID 18845633
  4. Somatostatin receptors in wildtype and somatostatin deficient mice and their involvement in nitric oxide physiology in the retina. Mastrodimou N, et al. Neuropeptides, 2006 Oct. PMID 17010429
  5. Alterations in glucose homeostasis in SSTR1 gene-ablated mice. Wang XP, et al. Mol Cell Endocrinol, 2006 Mar 9. PMID 16406265

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SSTR5 is primarily expressed and colocalized intracellularly. Activation of SSTR2, 5 and CB1R protected huntingtin-mutant knock-in striatal neurons from quinolinic-acid-induced toxicity. Co-activation of SSTRs and CB1R resulted in loss of protective effects, delayed ERK1/2 phosphorylation and altered receptor complex composition.
    Title: Somatostatin and cannabinoid receptors crosstalk in protection of huntingtin knock-in striatal neuronal cells in response to quinolinic acid.
  2. This study showed that reduced expression of the Sstr1 which modulate antidepressant action in hippocampus.
    Title: Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment.
  3. The expression and localization of the three receptors (SSTR3-SSTR5) in wild-type (WT), single-knockout (SSTR1 KO) and double-knockout SSTR1/SSTR2 (DKO) mice, are reported.
    Title: Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.
  4. SSTR1 was expressed in Kolliker's organ on E14, on cochlear duct hair cells & supporting cells on E17 and only on the organ of Corti at birth, increasing & peaking at P14 but dropping off at P21.
    Title: Somatostatin receptor types 1 and 2 in the developing mammalian cochlea.
  5. SSTR1-like immunoreactivity increases in hypothalamus except in paraventricular nucleus of ApoD(-/-) mice.
    Title: Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain.
  6. SST and SSTRs might play an important role in regulation of neurodegeneration
    Title: Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic mice.
  7. Data suggest an important role for the brain somatostatin receptor 1 subtype in the modulation of the gastrointestinal response to activation of brain CRF pathways.
    Title: Central somatostatin receptor 1 activation reverses acute stress-related alterations of gastric and colonic motor function in mice.
  8. SSTR1 activation can inhibit insulin secretion in pancreatic beta-cells.
    Title: N-type Ca(2+) -channels in murine pancreatic beta-cells are inhibited by an exclusive coupling with somatostatin receptor subtype 1.
  9. sst1 receptor loss causes a significant increase in retinal levels of somatostatin-14 (SRIF) whereas it does not affect SRIF messenger RNA, indicating that sst1 receptors play a role in limiting retinal SRIF at the post-transcriptional level.
    Title: Genetic deletion of somatostatin receptor 1 alters somatostatinergic transmission in the mouse retina.
  10. Brain somatostatin receptors 1,2,4 and 5 are up-regulated in somatostatin-deficient mice, and SSTR3 is down-regulated.
    Title: Brain somatostatin receptors are up-regulated in somatostatin-deficient mice.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables somatostatin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables somatostatin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables somatostatin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables somatostatin receptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to estradiol stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somatostatin signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
somatostatin receptor type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411890.1 → NP_001398819.1  somatostatin receptor type 1

    Status: VALIDATED

    Source sequence(s)
    AC123932
    UniProtKB/Swiss-Prot
    P30873
    UniProtKB/TrEMBL
    Q543T0

  2. NM_009216.3 → NP_033242.1  somatostatin receptor type 1

    See identical proteins and their annotated locations for NP_033242.1

    Status: VALIDATED

    Source sequence(s)
    AC123932, AK046464
    Consensus CDS
    CCDS36456.1
    UniProtKB/Swiss-Prot
    P30873
    UniProtKB/TrEMBL
    Q543T0
    Related
    ENSMUSP00000106299.3, ENSMUST00000110671.3
    Conserved Domains (1) summary
    cd15970
    Location:59 → 334
    7tmA_SSTR1; somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    58258524..58262822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30873.1 GenPept UniProtKB/Swiss-Prot:P30873

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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