U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Smpd2 sphingomyelin phosphodiesterase 2, neutral [ Mus musculus (house mouse) ]

Gene ID: 20598, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Smpd2provided by MGI
Official Full Name
sphingomyelin phosphodiesterase 2, neutralprovided by MGI
Primary source
MGI:MGI:1278330
See related
Ensembl:ENSMUSG00000019822 AllianceGenome:MGI:1278330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nSMase; nSMase1
Summary
This gene encodes a protein with similarity to the human nSMase1 protein. In humans, the nSMase1 protein was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in bladder adult (RPKM 41.4), duodenum adult (RPKM 32.3) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 B1; 10 22.42 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41363168..41366410, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41487172..41490370, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2321 Neighboring gene zinc finger and BTB domain containing 24 Neighboring gene STARR-seq mESC enhancer starr_26452 Neighboring gene predicted gene, 51797 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41197812-41197921 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 6 Neighboring gene STARR-positive B cell enhancer ABC_E2932 Neighboring gene STARR-positive B cell enhancer ABC_E5127 Neighboring gene CD164 antigen

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts. Zhu Z, et al. Mol Neurobiol, 2022 May. PMID 35294731, Free PMC Article
  2. Structural requirements for catalysis and membrane targeting of mammalian enzymes with neutral sphingomyelinase and lysophospholipid phospholipase C activities. Analysis by chemical modification and site-directed mutagenesis. Rodrigues-Lima F, et al. J Biol Chem, 2000 Sep 8. PMID 10871611
  3. Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice. Zhong L, et al. J Lipid Res, 2018 May. PMID 29567647, Free PMC Article
  4. Peptidoglycan induces cyclooxygenase-2 expression in macrophages by activating the neutral sphingomyelinase-ceramide pathway. Chen BC, et al. J Biol Chem, 2009 Jul 31. PMID 19531467, Free PMC Article
  5. Neutral sphingomyelinases and nSMase2: bridging the gaps. Clarke CJ, et al. Biochim Biophys Acta, 2006 Dec. PMID 16938269

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo.
    Title: Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo.
  2. Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts.
    Title: Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts.
  3. results suggest that SMase-2 deficiency plays a role in the survival or proliferation of liver cancer stem-like cells, leading to spontaneous tumors, which is associated with tumor-specific effects on lipid homeostasis
    Title: Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice.
  4. cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 induction, whereas cells deficient in sphingosine kinase-1 and -2 exhibited higher levels of CCL5.
    Title: Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.
  5. nSMase2 has a role in ceramide generation, aberrant apoptosis, and lung injury under cigarette smoke exposure
    Title: Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury.
  6. Peptidoglycan activates the nSMase/ceramide pathway to induce MKK3/6/p38 MAPK activation, which in turn initiates NF-kappaB activation and ultimately induces COX-2 expression in macrophages.
    Title: Peptidoglycan induces cyclooxygenase-2 expression in macrophages by activating the neutral sphingomyelinase-ceramide pathway.
  7. NSMase-2 could be involved in IL-1beta-induced JNK activation in hepatocytes
    Title: Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation.
  8. Nuclear sphingomyelin-synthase and protein kinase C delta are expressed in melanoma cells
    Title: Nuclear sphingomyelin-synthase and protein kinase C delta in melanoma cells.
  9. Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase have roles in cutaneous aging
    Title: Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging.
  10. Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease. (nSMase 1)
    Title: Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables sphingomyelin phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingomyelin phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sphingomyelin phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sphingomyelin phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingolipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingomyelin catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sphingomyelin catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingomyelin catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingomyelin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in caveola IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in caveola ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell periphery IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
sphingomyelin phosphodiesterase 2
Names
N-SMase
lyso-PAF-PLC
lyso-platelet-activating factor-phospholipase C
neutral sphingomyelinase 1
NP_033239.1
XP_017169351.1
XP_030100833.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009213.3 → NP_033239.1  sphingomyelin phosphodiesterase 2

    See identical proteins and their annotated locations for NP_033239.1

    Status: VALIDATED

    Source sequence(s)
    AC153360
    Consensus CDS
    CCDS23805.1
    UniProtKB/Swiss-Prot
    O70572
    UniProtKB/TrEMBL
    Q8C6H6
    Related
    ENSMUSP00000019965.7, ENSMUST00000019965.13
    Conserved Domains (1) summary
    cl00490
    Location:14 → 279
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RNA

  1. NR_190511.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153360

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    41363168..41366410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244973.2 → XP_030100833.1  sphingomyelin phosphodiesterase 2 isoform X2

    Conserved Domains (1) summary
    cl00490
    Location:37 → 143
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. XM_017313862.2 → XP_017169351.1  sphingomyelin phosphodiesterase 2 isoform X1

    Conserved Domains (1) summary
    cl00490
    Location:85 → 294
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70572.1 GenPept UniProtKB/Swiss-Prot:O70572

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous