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Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [ Mus musculus (house mouse) ]

Gene ID: 20588, updated on 21-Apr-2024

Summary

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Official Symbol
Smarcc1provided by MGI
Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1provided by MGI
Primary source
MGI:MGI:1203524
See related
Ensembl:ENSMUSG00000032481 AllianceGenome:MGI:1203524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsc8; SRG3; msp3; BAF155
Summary
Enables chromatin binding activity. Acts upstream of or within several processes, including insulin receptor signaling pathway; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of transcription by RNA polymerase II. Located in XY body and nucleus. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 32.9), limb E14.5 (RPKM 21.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F2; 9 59.87 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109961129..110069773)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110132024..110240178)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DExH-box helicase 30 Neighboring gene STARR-positive B cell enhancer ABC_E6806 Neighboring gene predicted gene 10615 Neighboring gene predicted gene, 23377 Neighboring gene STARR-seq mESC enhancer starr_25255 Neighboring gene STARR-seq mESC enhancer starr_25257 Neighboring gene 4.5s RNA, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_25258 Neighboring gene chondroitin sulfate proteoglycan 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chromatin Regulator SRG3 Overexpression Protects against LPS/D-GalN-Induced Sepsis by Increasing IL10-Producing Macrophages and Decreasing IFNγ-Producing NK Cells in the Liver. Lee SW, et al. Int J Mol Sci, 2021 Mar 16. PMID 33809795, Free PMC Article
  2. Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors. Wu J, et al. Cell Rep, 2020 Nov 17. PMID 33207205, Free PMC Article
  3. The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo. Panamarova M, et al. Development, 2016 Apr 15. PMID 26952987, Free PMC Article
  4. Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages. Lee SW, et al. PLoS One, 2015. PMID 26147219, Free PMC Article
  5. Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Schaniel C, et al. Stem Cells, 2009 Dec. PMID 19785031, Free PMC Article

See all (135) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.
    Title: The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.
  2. Baf155 regulates skeletal muscle metabolism via HIF-1a signaling.
    Title: Baf155 regulates skeletal muscle metabolism via HIF-1a signaling.
  3. Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development.
    Title: Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development.
  4. Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors.
    Title: Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors.
  5. Chromatin Regulator SRG3 Overexpression Protects against LPS/D-GalN-Induced Sepsis by Increasing IL10-Producing Macrophages and Decreasing IFNgamma-Producing NK Cells in the Liver.
    Title: Chromatin Regulator SRG3 Overexpression Protects against LPS/D-GalN-Induced Sepsis by Increasing IL10-Producing Macrophages and Decreasing IFNγ-Producing NK Cells in the Liver.
  6. Forkhead Box O3a requires BAF57, a subunit of chromatin remodeler SWI/SNF complex for induction of p53 up-regulated modulator of apoptosis (Puma) in a model of Parkinson's disease.
    Title: Forkhead Box O3a requires BAF57, a subunit of chromatin remodeler SWI/SNF complex for induction of p53 up-regulated modulator of apoptosis (Puma) in a model of Parkinson's disease.
  7. the regulation of BAF155 by RBM15 depends on the activity of the mRNA methylation complex core catalytic subunit METTL3.
    Title: RBM15 Modulates the Function of Chromatin Remodeling Factor BAF155 Through RNA Methylation in Developing Cortex.
  8. Conditional deletion of BAF155 causes impaired proliferation of olfactory neurons and defective axonogenesis in the developing olfactory epithelium.
    Title: mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium.
  9. BAF155 mediates the interaction between BAF complexes and H3K27demethylases, controlling the global level of H3K27me2/3 and ultimately the gene expression program in cortical development.
    Title: Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.
  10. the role of BAF155 in late pre-implantation stages of mouse embryos
    Title: The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within chromosome organization TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of myoblast differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of G0 to G1 transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of nucleotide-excision repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of GBAF complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of RSC-type complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
  
part_of SWI/SNF complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SWI/SNF complex TAS
Traceable Author Statement
more info
 PubMed 
part_of SWI/SNF superfamily-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in XY body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of brahma complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nBAF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nBAF complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of npBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of npBAF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of npBAF complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear matrix NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SWI/SNF complex subunit SMARCC1
Names
BRG1-associated factor 155
SWI/SNF complex 155 kDa subunit
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
SWI3-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413569.1 → NP_001400498.1  SWI/SNF complex subunit SMARCC1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159372

  2. NM_001413570.1 → NP_001400499.1  SWI/SNF complex subunit SMARCC1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159372

  3. NM_001413571.1 → NP_001400500.1  SWI/SNF complex subunit SMARCC1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159372

  4. NM_001413572.1 → NP_001400501.1  SWI/SNF complex subunit SMARCC1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC159372

  5. NM_009211.3 → NP_033237.2  SWI/SNF complex subunit SMARCC1

    See identical proteins and their annotated locations for NP_033237.2

    Status: VALIDATED

    Source sequence(s)
    AC159372
    Consensus CDS
    CCDS23561.1
    UniProtKB/Swiss-Prot
    P97496, Q7TS80, Q7TT29
    UniProtKB/TrEMBL
    Q3UMX0, Q3UPK0
    Related
    ENSMUSP00000086094.6, ENSMUST00000088716.12
    Conserved Domains (5) summary
    COG5259
    Location:443 → 709
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam04433
    Location:451 → 536
    SWIRM; SWIRM domain
    pfam16495
    Location:882 → 953
    SWIRM-assoc_1; SWIRM-associated region 1
    pfam16496
    Location:31 → 444
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
    pfam16498
    Location:705 → 769
    SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    109961129..110069773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97496.2 GenPept UniProtKB/Swiss-Prot:P97496

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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